Clinical trials: Intestine
Obesity, Gut Microbiota Modulation
ESAN III - Energy Sensing in Depression
The purpose of this study is to assess the effects of carotenoids from natural carrot juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Obesity, Gut Microbiota Modulation, Immunomodulation
- Trial name
- NCT06985381
- Testing
- Carotenoid-rich juice, Control
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Colorectal Cancer, Colon Rectal Resection
Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer
Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal…
- Conditions
- Colorectal Cancer, Colon Rectal Resection, Oxidative Stress
- Trial name
- NCT01470586
- Testing
- Surgery for colorectal cancer
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. Hatzikosta General Hospital
Healthy, Clostridium Difficile Infection
The Impact of Proton Pump Inhibitors on the Fecal Microbiome
The investigators hypothesis is that daily use of a proton pump inhibitor (PPI) is associated with significant alterations in the healthy fecal microbiome that are similar to those seen in persons with an initial episode of…
- Trial name
- NCT01822977
- Testing
- omeprazole
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Shigellosis
A Human Challenge Study to Assess Protection of a Shigella Tetravalent Bioconjugate Vaccine
In this challenge study, the bioconjugate candidate vaccine Shigella4V2 will be tested for its ability to induce an immune response that protects healthy adult volunteers from infection with a wild-type Shigella sonnei strain…
- Trial name
- S4V03 (NCT06615375)
- Testing
- Shigella4V2
- Where
- 3 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- LimmaTech Biologics AG
Colorectal Cancer, Familial Adenomatous Polyposis
DNA Adductomics for Colorectal Cancer Investigation
This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls.
- Conditions
- Colorectal Cancer, Familial Adenomatous Polyposis, Hereditary Non-polyposis Colon Cancer, Lynch Syndrome
- Trial name
- adductomics (NCT04865601)
- Testing
- resectomy of the colon
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Reduction of Intestinal Inflammatory Activity
Proof of Concept Human Study: Dietary Intervention to Modify Intestinal Inflammation in IBD
The objective of this clinical study is to demonstrate efficacy and feasibility of a long-term dietary intervention to modify intestinal inflammation in high-risk patient cohorts.
- Trial name
- NCT05867537
- Testing
- Gluten-free diet
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Gastrointestinal Motility and Defecation Conditions
Efficacy of Coffee Versus Peppermint Oil Intake in Promoting GIT Motility After Cesarean Section
It is a comparison between coffee effect versus peppermint oil in promoting GIT motility after cesarean section
- Trial name
- NCT04110600
- Testing
- Coffee effect on early gastric motility, Efficacy pepper mint oil on motility
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Colorectal Adenoma and Carcinoma
Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma
The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression.
- Trial name
- NCT02947607
- Testing
- Colon biopsies
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Irritable Bowel Syndrome
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
This FTIH study is designed to assess the safety, tolerability and pharmacokinetic (PK) of escalating single and repeat oral doses of GSK3352589 in normal healthy volunteers.
- Trial name
- NCT03154086
- Testing
- GSK3352589
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Appendicitis, Surgical Site Infection
Are Double-ring Wound-edge Protectors Effective for Preventing Superficial Surgical Site Infection After Open Appendectomy?
This study aims to evaluate the utility of double-ring wound-edge protectors to prevent the development of superficial surgical site infections after open appendectomy.
- Trial name
- sSSI-2RWEPs (NCT04860570)
- Testing
- Double-ring wound-edge protector
- Where
- Spain
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- Hospital Medina del Campo
Eczema, Asthma
Influence of Probiotics on Atopy, Immunological Responses and Gut Microflora - Follow-up to 5 Years
The investigators had conducted a double-blind, randomized placebo-controlled clinical trial studying the effects of 6 months probiotics supplementation from birth on allergic disease and sensitization up to 2 years of age.
- Conditions
- Eczema, Asthma, Allergic Rhinitis
- Trial name
- NCT00365469
- Testing
- Probiotic
- Where
- Singapore
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Gene Expression
Impact of a Short-Term High Fat or Low Fat Diet on Intestinal Genes Expression Involved in the Cholesterol and Fatty Acid Metabolism
Dietary fat has been shown to modulate cholesterol and fatty acids homeostasis and several lines of evidence suggest that this effect is associated with changes in the regulation of different genes at the intestine level involved…
- Trial name
- DGENES (NCT01806441)
- Testing
- 3-days high fat diet, 3-days low fat diet
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Laval University
Bowel Preparation
A Phase 3 Trial in Bowel Preparation for Colonoscopy
This is a prospective randomized study compared with active control arm. The investigators compare the colon cleansing in patients undergoing colonoscopy.
- Trial name
- NCT05870553
- Testing
- CTP0301-A, CTP0301-B, Cool prep
- Where
- South Korea
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.
Gut Microbiota Modulation
STUDY OF THE EFFECTS OF L. CASEI DG® (ENTEROLACTIS BABY) IN HEALTHY PRETERM AND FULL-TERM INFANTS.
The goal of this clinical trial was to learn whether giving Enterolactis Baby®, a probiotic food supplement containing Lactobacillus casei DG® (under the new taxonomical denomination: Lacticaseibacillus paracasei DG, CNCM…
- Trial name
- NCT07882537
- Testing
- Enterolactis Baby® drops
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Alfasigma S.p.A.
Aging
Age-associated Arterial Dysfunction, Western Diet, and Aerobic Exercise: Role of the Gut Microbiome
The risk of developing cardiovascular diseases increases with aging largely due to age-related declines in the function of arteries (arterial dysfunction), which are influenced by common lifestyle factors such as consumption of a…
- Trial name
- NCT03334201
- Testing
- Western Diet, Non-Western Diet
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Prospective Study, Ulcerative Colitis in Remission
A Multicenter Prospective Cohort Study on the Clinical Prognosis of Ulcerative Colitis
Mucosal healing or histological remission is an important target for the treatment of inflammatory bowel disease. In this study, patients with mucosal healing are defined as a control group, observing their clinical outcomes for…
- Trial name
- NCT03698812
- Testing
- Colonoscope
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Hyperlipidemia
The Effect of Intranasal Insulin on Hepatic and Intestinal Triglyceride-rich Lipoprotein Production
This study compares the effect of insulin given as a nasal spray with a placebo. Insulin is a chemical messenger (hormone) in the body that controls fat (triglyceride) levels in the blood by controlling the amount of fat made by…
- Trial name
- LPNI (NCT03141827)
- Testing
- Insulin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
Gut Microbiome and Colorectal Cancer
Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries.
- Trial name
- NCT06748339
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Heliopolis University
Rectocele
Trial to Determine Which of Two Surgical Techniques Works Better to Correct Vaginal Bulging
Women with vaginal bulging who are undergoing laparoscopic sacrocolpopexy at Clarian Health are eligible to enroll in this study.
- Trial name
- NCT00988975
- Testing
- Insertion of pelvicol graft
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Urogynecology Associates, Indiana
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