Clinical trials: Intestine
Colorectal Cancer, Adenoma Colon
Characterization of Brazilian Colorectal Cancer Screening Population
Colorectal cancer (CRC) is the third most common type of cancer among men and the second among women in Brazil. Despite the high incidence and significance of CRC in Brazil, very little is known about its prevalence among the…
- Trial name
- NCT03355391
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Colon Polyp, Colon Adenoma
Impacts of Inspection During Instrument Insertion on Colonoscopy Quality
Small colon polyps which are found during colonoscopy insertion are sometimes difficult to find during withdrawal and thus missed.
- Trial name
- NCT03444090
- Testing
- Colon polypectomy
- Where
- Taiwan
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Rheumatoid Arthritis
Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood
Acupuncture is used and recommended by the WHO for the treatment of Rheumatoid Arthritis. The molecular bases of this recommendation are not known, the investigators want to compare with the usage of high-throughput molecular…
- Trial name
- NCT01619176
- Testing
- methotrexate, non-steroidal anti-inflammatory drug (NSAID), leflunomide
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Glucose Metabolism Disorders
The Anatomical Location, Cellular Origin and Molecular Basis of Gut-derived Glucagon Secretion
Delineation of the anatomical location, cellular origin and molecular basis of gut-derived glucagon secretion
- Trial name
- NCT03181191
- Testing
- Oral glucose tolerance test
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Colon Polyp
Collecting Recorded Videos of Colonoscopy Screening Tests
The study shall mainly help to better evaluate the performance the APDS device and secondly it may help to assess the potential of the future alpha version of the device to be a useful and effective for the detection of colon…
- Trial name
- NCT03891290
- Testing
- Collecting recorded videos of Colonoscopy screening tests of the general population
- Where
- Israel
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Magentiq Eye LTD
Inflammatory Bowel Diseases
Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis
1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2.
- Trial name
- NCT03259659
- Testing
- ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bowel; Ischemic, Acute
FLuorescence Guided Assessment of Mesenteric Ischemia in Emergency Surgery
This is a prospective, multicentre, non-randomized cohort study using real-time intraoperative visualization of bowel perfusion by indocyanine green (ICG) in all-cause bowel ischemia.
- Trial name
- FLAMES (NCT06322862)
- Testing
- Indocyanine green
- Where
- 5 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Digestive Irregularity, Digestive Discomfort
The PRIDE Study Probiotics on Regulation and Improving Digestive hEalth
The purpose of this study is to determine the effect of probiotic supplemented yogurt in reducing colonic transit time (CTT) in females between the ages of 18-65 years old.
- Conditions
- Digestive Irregularity, Digestive Discomfort, History of Straining During Bowel Movements, History of Hard or Lumpy Stools
- Trial name
- PRIDE (NCT01203462)
- Testing
- Probiotic strain of Bifidobacterium, No Bifidobacterium
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Spondylosis, Spondylolisthesis
Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum
Researchers are trying to identify is chewing gum improves bowel function after anterior lumbar interbody fusion
- Conditions
- Spondylosis, Spondylolisthesis, Neurogenic Claudication, Foraminal Stenosis
- Trial name
- NCT03945461
- Testing
- Chewing gum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Bacterially-synthesized Folate Absorption Across the Large Intestine
The purpose of this study is to determine whether folate produced by bacteria that live in our colon can be absorbed in human colon using a stable isotope method.
- Trial name
- NCT02299778
- Testing
- 13C6-p-aminobenzoic acid
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Ulcerative Colitis
Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU)
The purpose of this study is to investigate a new technique: Close Rectal Dissection (CRD) as restorative surgery for Ulcerative Colitis patients: the Close Rectal Ileo Pouch Anal Anastomosis (CR-IPAA).
- Trial name
- CR-IPAA (NCT01111708)
- Testing
- Close Rectal Dissection - IPAA
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Medical Center Nijmegen
Gut Microbiome, Prebiotic
ZOE BIOME Study: Biotics Influence on Microbiome Ecosystem
The differences observed in host gut microbiome communities between health and disease states, and between different dietary patterns, has led to an increase in the use of dietary modulations to influence microbiome composition…
- Conditions
- Gut Microbiome, Prebiotic, Probiotic, Postprandial Period
- Trial name
- NCT06231706
- Testing
- Prebiotic-like nut and seed mix, Bread Crouton, Probiotic capsule
- Where
- United Kingdom
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- King's College London
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Intestinal Bacteria Flora Disturbance
Multi-Antibiotic Resistance Carriage in Gut Flora
Prevalence Study evaluating the acquisition of carriage of multidrug-resistant Gram-negative bacteria (MDRGNB) in the gut flora in volunteers of French Armed Forces staying from 4 to 6 months outside France.
- Trial name
- MARC (NCT01591538)
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Da Volterra
Colo-rectal Cancer
Shield Post-Approval Study Protocol
The Shield post-approval study (PAS) is a prospective, longitudinal study supplemented with Real World Evidence (RWE) to evaluate the longitudinal performance of Shield in an average risk population at a second round of testing…
- Trial name
- SOLAR (NCT06880055)
- Testing
- Shield Blood Test for colo-rectal cancer Screening
- Where
- 69 sites in United States
- Volunteers
- 3,375 people, healthy volunteers welcome
- Sponsor
- Guardant Health, Inc.
Healthy
Study To Assess The Safety And Tolerability Of Increasing Single Doses Of ATR-107 (PF-05230900) In Healthy People
This is a "first in human" study to determine the safety and tolerability of the drug after single doses. Nine doses of increasing strength will be injected or infused (given into a vein) to 9 different groups of people.
- Trial name
- NCT01162889
- Testing
- ATR-107 (PF-05230900) SC Injection, ATR-107 (PF-05230900) IV Infusion
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Pfizer
Executive Functions (EF), Microbiome
Smoothie Program for Achieving and Resilient Kids
The proposed study will examine whether eating yogurt every day can improve brain and gut health in children. Prior research suggests that yogurt may support cognitive functions like self-control, but more studies are needed to…
- Conditions
- Executive Functions (EF), Microbiome, Dietary Quality
- Trial name
- SPARK (NCT07195474)
- Testing
- Yogurt Smoothie (1 per day), Yogurt Smoothie (2 per day), Fruit Juice Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Penn State University
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cardiovascular Disease
Theobromine, Vascular Function and Intestinal apoA-I Production
Rationale: Despite successful efforts to lower atherogenic serum low-density lipoprotein (LDL) cholesterol concentrations, a substantial residual cardiovascular risk remains.
- Trial name
- NCT02209025
- Testing
- Theobromine
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
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