Clinical trials: Intestine
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Functional Gastrointestinal Disorders
GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans
The inhibitory effect of low dose GLP-1 is investigated on prandial motility of the stomach, duodenum and jejunum in vivo in humans.
- Trial name
- GLPMOT (NCT02731664)
- Testing
- GLP-1, Intravenous saline
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Colon Polyps
Comparing Cold Biopsy Forceps Versus Cold Snare Biopsy for Colon Polyps
Comparing the efficacy of cold biopsy forceps versus cold snare biopsy for removing colon polyps.
- Trial name
- NCT01665898
- Testing
- Cold Biopsy forceps, Cold snare biopsy
- Where
- South Korea
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Incheon St.Mary's Hospital
Cardiovascular Disease
Farmed Fish Human Intervention Study
Consumption of fish can help to prevent cardiovascular disease. The precise way in which fish is beneficial is not fully understood.
- Trial name
- FISHDISH (NCT01916434)
- Testing
- High PUFA Salmon Fillets, Sustainable PUFA salmon, No salmon
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Nutrition, Healthy
Effect of L. Plantarum Probiotic Supplementation on Broccoli Sulforaphane Bioavailability: Randomised Double-blind Placebo-controlled Crossover Study
Broccoli has the precursor of an active compound (sulforaphane) that has shown a wide range of health promoting benefits. Sulforaphane formation depends on the conversion of glucoraphanin (precursor) by myrosinase enzyme.
- Trial name
- PRO-BROC (NCT06561893)
- Testing
- Broccoli sprouts extract supplementation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Colorectal Cancer
Patient-Centered Risk Adjusted Surveillance After Curative Resection of Colorectal Cancer
The long-term goal of this research is to develop new tools to guide patients, caregivers, and clinicians in making individualized decisions regarding colorectal cancer (CRC) surveillance.
- Trial name
- NCT02217865
- Testing
- Interviews - Colorectal Cancer Participants, Questionnaire, Focus Groups
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Adenoma
NORCCAP: Norwegian Colorectal Cancer Prevention Trial
The purpose of this study is to see if screening with flexible sigmoidoscopy (a flexible viewing tube) may reduce large bowel cancer and cancer deaths.
- Trial name
- NORCCAP (NCT00119912)
- Testing
- A 1 Intervention arm Flex Sig, A 2 Intervention arm Flex Sig + iFOBT
- Where
- Norway
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Healthy Volunteers
Study to Evaluate the Interaction Between Aspirin and Nexium
The purpose of this study is to assess the interaction between aspirin and Nexium in healthy volunteers.
- Trial name
- NCT01199328
- Testing
- Aspirin, Esomeprazole
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Bowel Preparation Scale, Adenoma Detection Rate
Impact of Reinforced Education by Video on the Quality of Bowel Preparation
High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of reinforced education by Video on the quality of bowel preparation.
- Trial name
- NCT03185299
- Testing
- Video, Standard preparation instructions
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Preterm Infants, Term Infants
The Intestinal Innate Immune System in Newborns. Development and Inflammation in Health and Disease
The goal of this observational study is to determine the normal development of the human intestinal immune system in premature and mature neonatal life and to determine the pathophysiology behind life-threatening gastrointestinal…
- Conditions
- Preterm Infants, Term Infants, Necrotising Enterocolitis, Atresia; Bowel
- Trial name
- INTINE (NCT06092463)
- Where
- 2 sites in Denmark
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Caregiver, Malignant Neoplasm
Patient Portal and Navigation Program in Providing Information for Asian American Cancer Patients
This phase I/II trial studies how well patient portal and navigation program work in providing information for Asian American cancer patients.
- Conditions
- Caregiver, Malignant Neoplasm, Physician, Stage I Colorectal Cancer AJCC v8
- Trial name
- NCT03867916
- Testing
- Patient Navigation Program, Quality-of-Life Assessment, Survey Administration
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Functional Bloating (Disorder)
Pre-FIBRe Study: Predeterminants of Fibre Induced Bloating Response.
This study is an exploratory study aimed at gaining a greater understanding of the cause of abdominal bloating in response to two distinct fibre types.
- Trial name
- Pre-FIBRe (NCT04802798)
- Testing
- Fibre 1, Fibre 2
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- King's College London
Gastroesophageal Reflux Disease, Obesity
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
The investigators long-term goal is to understand how PPIs influence energy balance in both obese and normal-weight individuals.
- Trial name
- NCT02457104
- Testing
- Colonoscopy, Weight and diet questionnaire
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Fibromyalgia
Exploration the Mechanism of Ba-Duan-Jin Therapy in the Management of Fibromyalgia
Fibromyalgia (FM) is a chronic debilitating musculoskeletal pain syndrome. "Central sensitization" is an important mechanism of the disease.
- Trial name
- NCT03890133
- Testing
- Ba-Duan-Jin, Pregabalin capsule
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Type 2 Diabetes Mellitus, Dyslipidemias
Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes
Microbiota is important for immunology, hormonal and metabolic homeostasis in human and could influence on developing diabetes and obesity.
- Trial name
- NCT03204799
- Testing
- Metformin, SGLT2 inhibitor, ezetimibe
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Hemorrhoids
Evaluation of Allium Ampeloprasum Spp.Iranicum Cream Effect for the Management of Hemorrhoids Symptoms
Purpose of study is evaluation of Allium ampeloprasum Spp.Iranicum cream efficacy in management of symptomatic hemorrhoids in a double blind randomized placebo-control trial
- Trial name
- NCT02301052
- Testing
- Leek topical cream, Anti-hemorrhoid topical cream
- Where
- Iran
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Pancreatic Cancer
Using Digestive Microbial Information to Enhance the Early Detection of Pancreatic Cancer
Pancreatic cancer (PCA) is a leading death-related cancer. There is an urgent need for accurate, noninvasive diagnostic options in the early detection of pancreatic cancer (PCA), since delayed diagnosis increases the risk of…
- Trial name
- NCT05689138
- Testing
- Oral and Fecal Sample Collection
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Obesity, Overweight
The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children
This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).
- Conditions
- Obesity, Overweight, Type 1 Diabetes Mellitus
- Trial name
- NCT02938806
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Ulcerative Colitis (UC)
A First-in-Human Study of BB-TL1A-VIAL-HLE in Healthy Adults and People With Ulcerative Colitis
The goal of this clinical trial is to learn if BB-TL1A-VIAL-HLE is safe in healthy adults and is safe and effective in treating adults with moderate-to-severe ulcerative colitis.
- Trial name
- NCT07029971
- Testing
- BB-TL1A-VIAL-HLE
- Where
- 2 sites in Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vial Australia Pty Ltd
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