Clinical trials: Intestine
Diarrhea-predominant Irritable Bowel Syndrome
Effects of Vitamin D on Gut Microbiota, Intestinal Barrier in IBS-D Patients
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease. Evidence suggests that the concentration of serum VD is decreased in IBS patients, particularly in IBS-D.
- Trial name
- NCT05593367
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Colorectal Cancer
Colonoscopy or Fecal Occult Blood Test in Screening Healthy Participants for Colorectal Cancer
RATIONALE: Screening tests, such as colonoscopy and fecal occult blood test, may help doctors find tumor cells early and plan better treatment for colorectal cancer.
- Trial name
- 00-046 (NCT00102011)
- Testing
- annual screening, fecal occult blood test, screening colonoscopy
- Where
- 4 sites in United States
- Volunteers
- 4,952 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Inflammatory Bowel Diseases
Intestinal Stem Cells Characterization
A monocentric pilot studying intestinal organoids from endoscopic biopsies of IBD (Crohn and ulcerative colitis), FAP patients and healthy controls.
- Trial name
- BIODIGE (NCT02874365)
- Testing
- Endoscopic biopsies
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Colonoscopy, Colon Disease
Three Distraction Methods for Pain Reduction During Colonoscopy
Colonoscopy is a common procedure to evaluate the gastrointestinal tract. The colonoscopy procedure can sometimes be uncomfortable and painful for the patient.
- Trial name
- NCT05378165
- Testing
- Music group, Stress ball group, Video group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kastamonu University
Ulcerative Colitis
Oncostatin M in Ulcerative Colitis Patients
Ulcerative colitis (UC) is a refractory disease characterized by symptoms such as diarrhea, bloody stools, and abdominal pain with repeated relapses and remissions.
- Trial name
- NCT05974332
- Testing
- Oncostatin M
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Irritable Bowel Syndrome
The Effect of the Low FODMAP Diet and Dietary Oligofructose on Gastrointestinal Form, Function and Microbiota
Some carbohydrates, complex sugars, which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- FOG (NCT02259465)
- Testing
- low FODMAP diet, Oligofructose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Overweight (BMI > 25), Obese, Otherwise Healthy Volunteers
L. Acidophilus (Strain TW01) on Gut Health, Body Composition, and Inflammation
This is a pilot research study to investigate the effects of a probiotic supplement (L. acidophilus, strain TW01) on substances found in the stool and bloodstream, gut bacteria composition, body composition, as well as any…
- Trial name
- NCT06912100
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Obesity, Metabolic Syndrome
Investigating the Possible Link Between Habitual Diet, Physical Activity, Sleeping Patterns, Obesity Status and Age With Gut Bacterial Composition, Gut Barrier Function, Metabolic Endotoxemia, Systemic Inflammation and Glycaemic Control.
In the UK, 25% of the adults are affected by metabolic syndrome (NHS, 2016). Metabolic syndrome is a cluster of different conditions including: hyperglycaemia, insulin resistance hypertriglyceridemia, dyslipidaemia and…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT03864107
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Hyperlipidemia
Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose
Increased postprandial plasma triglycerides are associated with increased cardiovascular risk. Chronic consumption of carbohydrates is associated with increased levels of triglycerides.
- Trial name
- glucose (NCT01694446)
- Testing
- Intraduodenal glucose or fructose
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Gastric Intestinal Metaplasia, Gastric Cancer
Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation
The aim of the study will be to analyze the microbiome in the blood and stomach in patients with intestinal metaplasia (IM) and / or gastric cancer (GC).
- Conditions
- Gastric Intestinal Metaplasia, Gastric Cancer, Microbiome
- Trial name
- NCT04365946
- Testing
- Gastroscopy
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
ADHD
Improving ADHD Symptoms and Quality of Life Through Diet
The goal of this randomised controlled trial is to evaluate whether a specific dietary intervention can reduce core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in adults aged 18 to 50 years.
- Trial name
- ADAPT (NCT07376746)
- Testing
- Combined diet
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College Cork
Healthy, Colitis, Ulcerative
A Study of JNJ-66525433 in Healthy Participants and Participants With Ulcerative Colitis
The purpose of this study is to evaluate safety and tolerability of JNJ 66525433 compared with placebo after administration of: 1) single ascending oral doses of JNJ 66525433 administered to healthy participants (Part 1), 2)…
- Trial name
- NCT04457960
- Testing
- JNJ-66525433
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Breast Cancer, Colon Cancer
Physician Use of Non-English Language Skills in Cancer Care
The purpose of this study is to test a method for analyzing interactions between patients and doctors, the Roter Interaction Analysis System (RIAS).
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- NCT02726360
- Testing
- survey, Audio record
- Where
- 5 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Symptoms and Signs, Malignancy
Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy
Endoscopy is the best means of finding early stage of upper gastrointestinal diseases, especially early cancer and benign ulcers.
- Conditions
- Symptoms and Signs, Malignancy, Ulcer Peptic
- Trial name
- NCT03736824
- Testing
- endoscopy
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Celiac Disease, Hypothyroidism
Detection of Celiac Disease in Patients With Hypothyroidism
The study evaluates whether hypothyroid patients requiring elevated doses of levothyroxine to maintain a euthyroid state are at increased risk of having celiac disease.
- Conditions
- Celiac Disease, Hypothyroidism, Celiac Sprue, Malabsorption
- Trial name
- NCT01862510
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Obesity, Diabetes
Acute Effects of Dietary Fiber on Postprandial Responses in Lean and Overweight Subjects
It has been suggested that obesity occurs because the colonic microbes in obese individuals, compared to those who are lean, produce more short chain fatty acids during the fermentation of dietary fiber; this means that obese…
- Trial name
- NCT02795559
- Testing
- Glucose, Inulin, Resistant starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Colorectal Neoplasm
Enhancing Prevention Pathways Toward Tribal Colorectal Health
Recent improvements in colorectal cancer (CRC) incidence, mortality, stage at diagnosis, and survival in the general U.S. population have been attributed to routine screening with prompt removal of polyps, early detection, and…
- Trial name
- NCT02882620
- Testing
- High Intensity (Group 1), Medium Intensity (Group 2), Reference Group (Group 3)
- Where
- United States
- Volunteers
- 1,788 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Celiac Disease
Probiotic Blend for Celiac Disease
The objective of the study is to develop a probiotic product (B. longum CCT 1934; B. lactis CCT 7858; L. rhamnosus CCT 7863; S. thermophilus ATCC 19258) to reduce the symptoms caused by celiac disease and concomitantly improve…
- Trial name
- NCT05646823
- Testing
- Probiotic blend
- Where
- Brazil
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Central Nervous System Sensitization
Correlation Between Central Sensitization Inventory and Posturographic Data
To investigate the use of balance as a screening tool for Central Sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain.
- Trial name
- NCT03058003
- Testing
- Posturography Evaluation, Central Sensitization Inventory
- Where
- 2 sites in United States, Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Caps Research Network
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