Clinical trials: Intestine
Colorectal Cancer
Ancillary Study of Methylation Biomarkers in a Randomized Controlled Trial of a Personalized Prevention of Colorectal Cancer
Based on the magnesium tolerance test (MTT, "gold standard" for assessing magnesium (Mg) status), it was found that over 50% of participants in the US exhibited Mg deficiency.
- Trial name
- NCT04196803
- Testing
- Magnesium glycinate
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colorectal Neoplasms
Alcohol Intake, Alcohol Metabolizing Enzymes Gene Polymorphisms and the Risk of Colorectal Cancer
According to the statistic reports from World Health Organization (WHO) International Agency for Research on Cancer (IARC), the incidence and mortality rate of colorectal cancer ranked third and fourth respectively among ten most…
- Trial name
- NCT03155542
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
Specimens for Septin 9 Performance
Epigenomics has identified methylated gene regions that are specific for colorectal cancer (CRC). Through Epigenomics' marker discovery and validation process Septin 9 was identified as a particularly robust methylation marker…
- Trial name
- SPR0012 (NCT01329718)
- Testing
- Blood Sample
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Intestinal Diseases, Gluten-sensitive
Gluten Sensibility in Elite Athletes
This clinical project aims to study the relationship between gluten consumption and its impact on digestive comfort, quality of life and performance of non-celiac athletes practicing an intensive physical activity..
- Trial name
- GLUTHEALTH (NCT03101410)
- Testing
- Gluten, Gluten free
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Malnutrition, Child, Enteropathy
Study of Environmental Enteropathy and Malnutrition in Pakistan
Environmental Enteropathy (EE) is an acquired sub-clinical inflammatory gut condition in which alterations in intestinal structure, function, and local and systemic immune activation lead to impaired vaccine responses, decreased…
- Conditions
- Malnutrition, Child, Enteropathy, Vaccine Response Impaired, Stunting
- Trial name
- SEEM (NCT03588013)
- Testing
- Nutritional education, Ready to Use Therapeutic Food, Upper gastrointestinal endoscopy with biopsy
- Where
- Pakistan
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Colorectal Neoplasms
Understanding Sugar-Sweetened Beverages (SSB) and Colorectal Cancer (CRC)
This study will recruit and consent approximately 120 subjects in the baseline study until the follow-up study recruitment goals of 20 subjects is met.
- Trial name
- SSB and CRC (NCT06669923)
- Testing
- iSIPsmarter Program, Patient Education
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Infertility, Male, Azoospermia
The Association of Gut Microbiota and Spermatogenic Dysfunction
This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata.
- Conditions
- Infertility, Male, Azoospermia, Oligozoospermia, Asthenozoospermia
- Trial name
- NCT05628987
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Colorectal Cancer
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Colorectal cancer is a common disease worldwide. Increasing evidence is demonstrating that colorectal cancers arise from 'cancer stem cells.' Stem cells in the colon reside at the bottom of thousands of microscopic crypts…
- Trial name
- NCT01075893
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Cancer Colorectal
Calm for Cancer Patients Receiving Chemotherapy
Chemotherapy is a common strategy used to treat colorectal cancer patients, but is often leads patients and survivors to experience a host of symptoms, of which acute emotional distress is a major concern.
- Trial name
- NCT04345952
- Testing
- Calm Meditation Mobile App
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Colorectal Carcinoma
Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
Lubiprostone as an adjunct to the standard bowel preparation regime the quality of bowel preparation can be improved for a good colonoscopic examination without missing lesions and complications.
- Trial name
- Lubiprostone (NCT01324284)
- Testing
- Lubiprostone
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Roux-en-Y Bariatric Surgery
Investigation of the Effects of Obesity Surgery on Appetitive Behaviour
Among all the existing ways to treat obesity (lifestyle, pharmacological), Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective.
- Trial name
- NCT02010385
- Testing
- Octreotide, Saline
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Fecal Calprotectin in Intestinal Protozoa
Fecal Calprotectin in Patients Infected with Intestinal Protozoan Infections
Calprotectin extracted from stool can be detected easily using ELISA. Numerous studies have shown that fecal calprotectin concentrations demonstrate a good correlation with intestinal inflammation This study aims to detect the…
- Trial name
- NCT06890455
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Inflammatory Bowel Diseases
Serum NGAL as a Predictor of Clinical and Endoscopic Activity of Inflammatory Bowel Disease
Ulcerative colitis (UC) and Crohns disease (CD) represent the two major forms of inflammatory bowel disease (IBD), characterized by epithelial cell damage and prominent mucosal infiltration by inflammatory cells including…
- Trial name
- NCT05151458
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colorectal Cancer
REINFORCEMENT ANASTOMOSIS WITH Modified Cyanacrylate IN Patients Undergoing to Oncologic Colorectal Surgery With Colorectal Anastomosis
In colorectal surgery about 30% of postoperative mortality is attributed to anastomotic leak, whit an incidence range between 1.8% and 15.9%.
- Trial name
- ANASTOSEAL (NCT03380858)
- Testing
- colectomy
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute, Naples
Colorectal Neoplasms, Colonic Polyps
Study of Flat Polyp Detection Using New Narrow Band Imaging (NBI) Compared to White Light Colonoscopy - The FIND FLAT Colonoscopy Study
We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm.
- Conditions
- Colorectal Neoplasms, Colonic Polyps, Colorectal Cancer
- Trial name
- NBI (NCT01310699)
- Testing
- Olympus Colonoscope CFHQ190AL
- Where
- 3 sites in United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Constipation, Irregular Bowel Movement Frequency
IQP-PO-101 for the Regulation of Bowel Movement Frequency
The purpose of the study is to evaluate the safety and efficacy of IQP-PO-101 in regulating the bowel movement frequency
- Trial name
- NCT01809587
- Testing
- IQP-PO-101
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Ulcerative Colitis
A Study of LIV001 in Healthy Subjects and Those with Mild-to-Moderate Active Ulcerative Colitis (UC)
This study is only for the first in human phase 1a study designed to investigate the safety and tolerability of LIV001 in healthy participants.
- Trial name
- NCT05975047
- Testing
- LIV001
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Liveome Inc.
Spinal Cord Injury, Neurogenic Bowel Dysfunction
Artificial Int: Neurogenic Bowel Education in Spinal Cord Injury Patients
The aim of this study is to evaluate the effectiveness of patient education delivered through an artificial intelligence (AI)-based mobile application in the management of neurogenic bowel dysfunction in individuals with spinal…
- Trial name
- ArtInt (NCT07369349)
- Testing
- Mobil Application
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Senem Duman
Inflammatory Bowel Disease
A Randomized, Double-Blind, Dose-Escalation, Placebo-Controlled Phase I Clinical Trial Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Oral Doses of HRS-7085 Tablets in Healthy Subjects, With Assessment of Food Effects
This is a multicenter, randomized, double-blind, placebo-parallel-controlled, Phase I clinical trial investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of HRS-7085…
- Trial name
- NCT06175949
- Testing
- HRS-7085 Tablets, HRS-7085 simulant
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Gut Microbiota
Impact of Probiotics Supplement on the Gut Microbiota in Caesarean-born Infants
The purpose of this study is to evaluate the effect of probiotics on the gut microbiota of infants born by cesarean section.
- Trial name
- NCT05086458
- Testing
- probiotics
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
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