Clinical trials: Intestines
Intestinal Permeability, Gastrointestinal Function
The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults
In this double blind, crossover study participants will consume a cranberry beverage and a cranberry-flavored beverage for 2 weeks each. Gut permeability will be assessed weekly using aspirin and food-grade sugar molecules.
- Trial name
- MAC (NCT03957239)
- Testing
- Cranberry Beverage, Control Beverage
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 2 Diabetes
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.
The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
- Trial name
- NCT01043445
- Testing
- GPR 119 agonist, 2-oleyl glycerol, Oleic acid, Vehicle
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Tuberculosis, Gastric Cancer
Volatiles in Breath and Headspace Analysis - Diagnostic Markers
Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendly novel nano-chemo sensors that can…
- Conditions
- Tuberculosis, Gastric Cancer, Peptic Ulcer, Atrophic Gastritis
- Trial name
- Volatolome (NCT03228095)
- Testing
- VOC detection in breath and in skin headspace, Breath sampling, Upper endoscopy with biopsies
- Where
- Latvia
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
In this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to…
- Trial name
- NCT02847312
- Testing
- High avenanthramide, phenolic acid, Low avenanthramide, medium phenolic acid, Control
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
Urinary Incontinence, Stress, Fecal Incontinence
Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter?
A double-blinded, randomized, crossover study in healthy females with placebo and single dose imipramine 50 mg. Primary objective: Does imipramine increase the tone of the external urethral sphincter? Urethral Opening Pressure…
- Trial name
- NCT03102645
- Testing
- Imipramine Hydrochloride 25 MG
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jonatan Kornholt
Athletic Performance, Gut Health
Decoding Gut-Brain Biomarkers and Developing a Minimally Intrusive Gut Microbiome Sampling: Enhancing Cognitive Well-being in Athletes
The objective of this study is to assess the impact of a psychobiotic supplement on the gut health, neurological markers, and behavior of younger soccer players over the soccer season.
- Trial name
- NCT07093112
- Testing
- Psychobiotic supplement
- Where
- Brazil
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Crohn Disease
Early MRI Prediction of Crohns
The investigators plan a prospective study designed to optimize and translate noncontrast, novel Magnetic Resonance Imaging (MRI) techniques for detecting and measuring intestinal inflammation as well as for allowing early…
- Trial name
- NCT03340519
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypovitaminosis D, Hypovitaminosis
Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel
The main purpose of this research study is to learn about the effects of supplemental vitamin D3 and vitamin K2 on blood levels and the gut microbial community, called the gut microbiome.
- Trial name
- NCT07199829
- Testing
- Vitamin Arm 1, Vitamin Arm 2, Vitamin Arm 3
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Bowel Preparation, Colonoscopy
External Validation of a Predictive Model for Bowel Preparation in Patients Undergoing Colonoscopy
Bowel preparation is closely lined to the quality of colonoscopy, inadequate bowel preparation (IBP) could lead to higher miss rate of adenomas, patients' discomfort and higher health expense.
- Trial name
- NCT04325139
- Testing
- Questionnaire
- Where
- 12 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Human Gut Microbiota
The QIB Colon Model
The aim of this project is to establish a list of volunteers willing and able to donate stool samples for use in the model colon so as to facilitate research directed toward understanding the basic science underlying the…
- Trial name
- NCT02653001
- Testing
- Stool sample collection
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Overweight or Obesity, Metabolic Syndrome
Fermented Dairy Products and The Metabolic Syndrome
The study will be conducted as a randomized controlled trial with four parallel arms including four dairy products. We will investigate the health effects of including yogurt in the diet through a 16-weeks intervention period…
- Trial name
- FerMetS (NCT04755530)
- Testing
- Regular whole milk, Yogurt with live bacteria, Yogurt with inactivated bacteria
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Faidon Magkos
Colon Cancer, Polyp
Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening.
The proposed research aims to determine the prevalence, size, shape and histology of flat colorectal neoplasms in a cohort of asymptomatic, average-risk individuals presenting for screening colonoscopy.
- Conditions
- Colon Cancer, Polyp, Adenoma
- Trial name
- NCT00245492
- Testing
- Chromocolonoscopy
- Where
- 3 sites in United States
- Volunteers
- 792 people, healthy volunteers welcome
- Sponsor
- Indiana University
Irritable Bowel Syndrome With Constipation
An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation Predominant
Our previous work on the use of probiotics improved the clinical symptoms in irritable bowel syndrome with constipation-predominant.
- Trial name
- NCT04647045
- Testing
- Cultured milk drink
- Where
- Malaysia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Microbiota
Effect of Consuming a Mango and Chia-based Beverage on Modulating the Intestinal Microbiota in Obese Children
This randomized clinical trial evaluates the effect of a mango and chia-based beverage on gut microbiota modulation in 100 Paraguayan children aged 8-16 years with obesity.
- Trial name
- NCT07529119
- Testing
- Mango juice, Mango and chia juice
- Where
- Paraguay
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Caaguazu
Human Microbiome, Eating Behavior
Snack Foods and Their Impact on Gastrointestinal Microbiology, Function and Symptoms
The purpose of this study is to evaluate the impact of replacing usual snacks with alternative snack foods on gut health in a population of habitual snackers with low fibre intake.
- Trial name
- OptiGut (NCT03581812)
- Testing
- Intervention snack 1, Intervention snack 2, Control snack
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- King's College London
Constipation-predominant Irritable Bowel Syndrome
Effect of Saccharomyces Cerevisiae on the Improvement of Gastro-intestinal Disorders Associated to IBS With C Phenotype
The main objective is to assess the effect of an 8-week daily supplementation with IbSium® (probiotic yeast Saccharomyces cerevisiae CNCM I-3856) on the improvement gastro-intestinal disorders associated to the type C IBS…
- Trial name
- IBS-GO (NCT03150212)
- Testing
- Saccharomyces cerevisiae CNCM I-3856
- Where
- 5 sites in France
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Gastric Cancer, Pancreatic Cancer
Chemoradiation-Induced Nausea and Emesis: Quality of Life
The primary objectives of this study are: 1. To assess the preferences of cancer patients scheduled to receive chemoradiation and caregiver controls for side-effects of chemoradiation. 1.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Cervical Cancer, Vulvar Cancer
- Trial name
- NCT00394602
- Testing
- Interview, Questionnaire
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Body Image Disorder
Prevention of Body Image Disorder by Nurse Intervention on the Patient and Family Prior to Breast and Colon Surgery
This is a non-blinded, randomized, controlled clinical trial consisting of 64 participants, which aims to assess the effectiveness of a nursing intervention for family members and patients prior to surgery to prevent body image…
- Trial name
- NCT03726801
- Testing
- HEALTH EDUCATION
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Healthy
Methionine Intake Microbiota
Pro-inflammatory immune cells play a pivotal role in multiple sclerosis, and the gut microbiota is increasingly recognized as a key factor shaping the immune system.
- Trial name
- NCT07283328
- Testing
- Methionine-restricted diet
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
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