Clinical trials: Intestines
Colorectal Cancer, Opioid-free Anesthesia
Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery
Adult patients aged 18-80 years old, American Society of Anesthesiologists physical status I-III, who were scheduled for elective colorectal cancer surgery under general anesthesia were recruited for this study.
- Conditions
- Colorectal Cancer, Opioid-free Anesthesia, NETs
- Trial name
- NCT07264556
- Testing
- OA strategy, OSA stategy, OFA strategy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
Metastatic Colorectal Cancer, Gastric Cancer
Vactosertib in Combination with Pembrolizumab in Metastatic Colorectal or Gastric Cancer
This is an open-label, multicenter study to assess the safety, tolerability, pharmacokinetics, and antitumor activity of vactosertib in combination with pembrolizumab in patients with metastatic or locally advanced colorectal or…
- Conditions
- Metastatic Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT03724851
- Testing
- TEW-7197
- Where
- 5 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- MedPacto, Inc.
Ulcerative Colitis
Treatment of Ulcerative Colitis With Rectal Instillation of Qinghua Quyu Prescription(QHQYP)
This study will enroll 60 patients with mild to moderate active ulcerative colitis as subjects. They will be randomly divided into two groups: the TCM group received QHQYP rectal instillation, while the control group received…
- Trial name
- QHQYP (NCT05780723)
- Testing
- Treatment group: Rectal instillation of QHQYP, Control group: Mesalazine enema treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Head and Neck Squamous Cell Carcinoma, Colorectal Cancer
Study of NKTR 255 in Combination With Cetuximab in Solid Tumors
This is a Phase 1b/2, open-label multicenter study evaluating NKTR-255 as a monotherapy and together with cetuximab in patients with head and neck squamous cell carcinoma (HNSCC) and colorectal carcinoma (CRC).
- Trial name
- NCT04616196
- Testing
- NKTR-255, Cetuximab
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Nektar Therapeutics
Hirschsprung Disease
A Trial on Conservative Treatment for Infants' Hirschsprung Disease
The present study was designed to compare the efficacy of conservative treatment to operative treatment for improvement of constipation symptoms in infants with short or normal-segment Hirschsprung disease.
- Trial name
- NCT01985646
- Testing
- surgery treatment, anal dilation, colonic lavage
- Volunteers
- 48 people
- Sponsor
- Tongji Hospital
Inflammatory Bowel Diseases, Ulcerative Colitis
Global IBD Visualization of Epidemiology Studies (GIVES) in the 21st Century
Crohn's disease (CD) and Ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) of unknown etiology. The pathophysiology of IBD relates to the mucosal immune response to antigenic stimulation from the gut…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- GIVES-21 (NCT04748627)
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stage I Breast Cancer, Stage II Breast Cancer
Acupuncture Pilot Study for Cancer-related Cognitive Function
This study is being done to explore whether acupuncture can improve cognitive difficulties in patients diagnosed with cancer.
- Conditions
- Stage I Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer, Stage I Colorectal Cancer
- Trial name
- NCT04007770
- Testing
- Acupuncture, 16 week waiting period + optional Acupuncture
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Barrett's Esophagus, Esophageal Adenocarcinoma
Stratifying Risk in Barrett's Esophagus: A Pilot Study for Biomarker-based Patient Management
Subjects enrolled in this study will have biopsies obtained and sent to Dr. Fitzgerald's lab for analysis of a validated biomarker panel.
- Conditions
- Barrett's Esophagus, Esophageal Adenocarcinoma, Intestinal Metaplasia, Dysplasia
- Trial name
- NCT02075905
- Where
- 4 sites in United States, Netherlands and 1 more
- Volunteers
- 111 people
- Sponsor
- University of North Carolina, Chapel Hill
Rectal Fistula
Mesenchymal Stem Cells (MSCs) for Perianal Fistula
OSSM-001 will be evaluated in a double blind, randomized phase I safety study of a single injection of 100 and 300 million bone marrow derived MSCs in 16 patients with refractory perianal fistulas in the setting of Crohn's…
- Trial name
- NCT05407766
- Testing
- OSSM-001
- Sponsor
- Ossium Health, Inc.
Granulomatous Colitis, Crohn's Disease
An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease
The purpose of this study is to assess the safety and effectiveness of BMS-986165 compared to placebo in participants with moderately to severely active Crohn's Disease.
- Conditions
- Granulomatous Colitis, Crohn's Disease, Crohn's Enteritis, Granulomatous Enteritis
- Trial name
- NCT03599622
- Testing
- BMS-986165
- Where
- 259 sites in United States, Australia and 24 more
- Volunteers
- 239 people
- Sponsor
- Bristol-Myers Squibb
Frailty, Microbiota
Relationship Between Frailty and Gut Microbiota in Older Adults: An Educational Program for Healthy Aging
The main objective of this pre-experimental study is to describe the relationship between gut microbiota and changes in the degree of frailty in older adults who participated in an educational program.
- Trial name
- FRAGBIOTA (NCT07251322)
- Testing
- Fecal sample collection
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- University of Cadiz
Infection, Bacterial
Stool Biobanking and Impact of Antimicrobials on the Gut Microbiota in Patients With Bone and Joint Infection
Bone and joint infections (BJI) is a public health issue in industrialized countries. Implant-associated BJI, are complex hospital-acquired infections and eradication of the pathogen is challenging in such patients.
- Trial name
- GUMIBONE (NCT03633188)
- Testing
- Patients treated by antibiotherapy
- Where
- 4 sites in France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Gut Microbiota
Gut Mini-Pill Study
The purpose of this proof-of-concept study in humans is to determine if a noninvasive, ingestible device, called a "mini-pill", can collect gastrointestinal (GI) luminal content samples from 2 different locations along the GI…
- Trial name
- NCT07220369
- Testing
- plant-based meat alternative entrees, mini-pill, meat based entree
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Ulcerative Colitis, Inflammatory Bowel Diseases
BOOM-IBD2 Pivotal Clinical Trial
Ulcerative colitis is a long-lasting condition that causes swelling and sores in the large intestine. This study tests whether a small device placed under the skin can help reduce bowel urgency in people with ulcerative colitis.
- Trial name
- NCT06571669
- Testing
- Neuromodulation
- Where
- 19 sites in United States
- Volunteers
- 137 people
- Sponsor
- Boomerang Medical
Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome Mixed
Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is the most common functional bowel disorder, being present in approximately 10% of adult Europoid population. The etiology of IBS is elusive.
- Trial name
- MISCEAT (NCT04899869)
- Testing
- Faecal microbiota transplantation with active study microbiota first, Faecal microbiota transplantation with inactive autoclaved study microbiota first, Faecal microbiota transplantation with inactive autoclaved study microbiota only
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- Thomayer University Hospital
Infant, Growth
Study on Fermentable Carbohydrates in Healthy Infants
The purpose of this project is to study the effect of fermentable carbohydrates in the nutrition of healthy infants.
- Conditions
- Infant, Growth, Nutrition, Healthy
- Trial name
- BAMBINOL (NCT00808756)
- Testing
- Fermentable carbohydrates., Standard infant formula.
- Where
- 2 sites in Spain
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Type 1 Diabetes, Type 2 Diabetes
Establishment of the Human Intestinal and Salivary Microbiota Biobank- Diabetes
This is a prospective, clinical, monocentric study aimed to collect biological samples and study microbiota from subjects suffering from type 1 diabetes mellitus, subjects suffering from type 2 diabetes mellitus and from healthy…
- Trial name
- BIOMIS-Diab (NCT04698122)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Hernia, Ventral, Hernias Intestinal
Optimization of Surgical Treatment of Patients With Incisional Ventral Hernias
The goal of our work of optimization of the treatment of postoperative hernias is to improve the results of treatment of patients with median and median-lateral postoperative hernias of medium (W2) and large (W3) sizes by…
- Conditions
- Hernia, Ventral, Hernias Intestinal, Hernia Abdominal Wall
- Trial name
- NCT05734222
- Testing
- A new method of repair of the abdominal wall of mid-lateral postoperative ventral hernias
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Samara State Medical University
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Inflammatory Bowel Disease
Colon Capsule Endoscopy in Children
The incidence of Inflammatory Bowel Diseases (IBD) is in a continuous progression both in adults as in children. The colonoscopy is considered as the gold standard exam for the diagnosis and the follow-up of the patients…
- Trial name
- VICCOINBODI (NCT02129972)
- Testing
- Colon videocapsule endoscopy (PillCam colon 2)
- Where
- 7 sites in France
- Volunteers
- 52 people
- Sponsor
- Hospices Civils de Lyon
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