Clinical trials: Intestines
Preterm Birth, Enterocolitis, Necrotizing
Study of the Influence of Intraperitoneal Insufflation of CO2 by Laparoscopy on the Short-term Evolution of Premature Infants With Ulcerative Necrotizing Enterocolitis
Ulcerative-necrotizing enterocolitis (ECUN) is an infectious and inflammatory disease of the digestive tract, which can lead to intestinal necrosis or perforation.
- Trial name
- NECO2 (NCT05882448)
- Testing
- laparotomy, Laparoscopy
- Where
- 2 sites in France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Blood Pressure
Salt and Gut Study
High sodium intake is a significant risk factor for hypertension. Recently, animal studies connect high sodium intake to the gut-immune axis and highlight the gut microbiome as a potential therapeutic target to counteract…
- Trial name
- NCT04958148
- Testing
- Salt pills
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Augusta University
Colorectal Cancer Metastatic
Evaluation of the Safety and the Tolerability of Durvalumab Plus Tremelimumab Combined With FOLFOX in mCRC
Colo-rectal cancer is still one of the leading causes of cancer death worldwide. In France, approximately 40 500 new cases are diagnosed each year.
- Trial name
- MEDITREME (NCT03202758)
- Testing
- Durvalumab, Tremelimumab and ,FOLFOX
- Where
- 5 sites in France
- Volunteers
- 57 people
- Sponsor
- Centre Georges Francois Leclerc
Crohn's Disease
Personality Traits and Its Impact on Quality of Life and Clinical Outcome Evaluation in Crohn's Patients
Quality of life is recommended as one of essential parameters to evaluate treatment effect and clinical outcome in patients with Crohn's disease (CD).
- Trial name
- NCT01887548
- Testing
- Personality Traits Questionnaires
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jinling Hospital, China
Colon Polyp
UEMR for Medium-sized Pedunculated Colon Polyps
Underwater EMR (UEMR) is an emerging technique for endoscopic resection. The purpose of this research is to observ wether the UEMR for medium-sized pedunculated polyps is safe and effective.
- Trial name
- NCT04837690
- Testing
- UEMR
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Ningbo No. 1 Hospital
Colorectal Cancer Stage II
First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer
Bevacizumab in combination with chemotherapy represents a standard of care for first-line treatment in patients with advanced colorectal cancer.
- Trial name
- CENTRAL (NCT01853813)
- Testing
- Bevacizumab and FOLFIRI
- Where
- 13 sites in Italy
- Volunteers
- 85 people
- Sponsor
- Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente
Colorectal Cancer
Single Incision Plus One Port Laparoscopic Surgery Assistant Enhanced Recovery After Surgery on Colorectal Cancer
Conventional laparoscopic surgery (CLS) for colorectal cancer has been demonstrated to be safe and feasible and present minimally invasive benefits including faster recovery, reduced postoperative pain and shorter hospital stay…
- Trial name
- NCT04268290
- Testing
- Single incision plus one port laparoscopic surgery
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ileus
Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database
Alvimopan is the first and currently the only FDA-approved therapy for acceleration of the time to upper and lower gastrointestinal (GI) recovery following partial large or small bowel resection surgery with primary anastomosis.
- Trial name
- NCT01150760
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 7,050 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Rectal Cancer, Recurrence
Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients
This study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase II clinical, imaging and translational research study.
- Conditions
- Rectal Cancer, Recurrence, Radiation Toxicity
- Trial name
- Re-RAD-I (NCT05816980)
- Testing
- Hyperfractionated external beam radiation
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Crohn Disease, Intestinal Tuberculosis
MRI Differentiating Gut TB and Crohn's
It is clinically challenging to differentiate Crohn's disease from gut tuberculosis especially in regions endemic of tuberculosis infection.
- Trial name
- NCT03096379
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Cancer Colon
The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment
Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world.
- Trial name
- NCT04079946
- Testing
- Total Mesocolic Excision with Central Vessel Ligation, conventional surgery of cancer colon
- Volunteers
- 40 people
- Sponsor
- Assiut University
Cystic Fibrosis
Intestine-lung Axis of Cystic Fibrosis Patients Treated With the Combination Elexacaftor/Tezacaftor/Ivacaftor
Cystic fibrosis is a systemic disease, which affects in particular the respiratory and digestive systems of patients, sites of chronic inflammation.
- Trial name
- KAF-BIOTA (NCT05937815)
- Testing
- Sample collection
- Where
- 15 sites in France
- Volunteers
- 253 people
- Sponsor
- University Hospital, Bordeaux
Crohn Disease
Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery
for some patients with Crohn's diseases undergoing surgery，whether exclusive enteral nutrition(EEN) could delay the disease relapse needs exploration.The trial will study whether the efficacy of postoperative EEN could help…
- Trial name
- NCT04160325
- Testing
- postoperative 3-month exclusive enteral nutrition, azathioprine, normal diet
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Zhu Weiming
Inflammatory Bowel Diseases, Crohn Disease
MOdel-Informed Precision Dosing of Ustekinumab and VEdolizumab in Inflammatory Bowel Disease
The goal of this clinical trial is to investigate if dosage of Ustekinumab (UST) and Vedolizumab (VDZ) based on Model-Informed Precision Dosing (MIPD) is equally as efficient in keeping adults with Inflammatory Bowel Disease…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- MOVE-IT (NCT06788340)
- Testing
- PK-model to decide when to dose Vedolizumab and Ustekinumab
- Where
- 6 sites in Denmark
- Volunteers
- 166 people
- Sponsor
- Odense University Hospital
Colorectal Cancer
Core Stability Program in Colorectal Cancer Survivors
The purpose of this study is to determine the effects of physical training program to improve deep stabilizer muscle in colorectal cancer survivors
- Trial name
- NCT02052050
- Testing
- core stability
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Granada
IBS in Celiac Desease
Probiotics for the Treatment of Irritable Bowel Syndrome in Celiac Patients
Probiotics play an important role in preventing overgrowth of potentially pathogenic bacteria and maintaining the integrity of the gut mucosal barrier.
- Trial name
- ProCel (NCT01699191)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Bari
CD55-deficient Protein-losing Enteropathy
Compassionate Use of Pozelimab
Provide compassionate use of pozelimab
- Trial name
- NCT05232110
- Testing
- Pozelimab
- Sponsor
- Regeneron Pharmaceuticals
Chronic Pelvic Pain, Interstitial Cystitis
Effect of Repetitive Transcranial Direct Current Stimulation (tDCS) on Chronic Pelvic Pain
We will rigorously test whether modulation of the motor cortex by transcranial direct current stimulation (tDCS) is an effective treatment for patients with chronic pelvic pain through the following specific aims: A) The primary…
- Conditions
- Chronic Pelvic Pain, Interstitial Cystitis, Post Traumatic Stress Disorder, Fibromyalgia
- Trial name
- NCT00554320
- Testing
- tDCS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Summa Health System
Crohn Disease, Resection Margins
Cellvizio to Evaluate Margins in Crohn's Ileal Disease
Crohn disease is an inflammatory bowel disease. A surgical procedure is required in about 80% of cases. Surgery doesn't cure from Crohn's disease but the type of surgery remains important as there are several intraoperative risk…
- Conditions
- Crohn Disease, Resection Margins, Recurrence
- Trial name
- CELLVICROHN (NCT05805020)
- Testing
- cellvizio
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Organ Preservation, Rectal Cancer
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
The goal of this prospective phase II feasibility study is to evaluate two additional local treatment options in rectal cancer patients with a good clinical response after neoadjuvant (chemo)radiation: contact x-ray brachytherapy…
- Conditions
- Organ Preservation, Rectal Cancer, Quality of Life, Locally Advanced Rectal Carcinoma
- Trial name
- OPAXX (NCT05772923)
- Testing
- Contact x-ray brachytherapy, Local excision
- Where
- 7 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
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