Clinical trials: Intra-arterial Thrombolysis
Medium Vessel Occlusion, Ischemic Stroke, Acute
Intra-arterial Thrombolysis For Acute Ischemic Stroke With Medium Vessel Occlusion
A multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) phase III trial is planned to evaluate the efficacy and safety of intra-arterial thrombolysis (IAT) in patients with acute ischemic stroke caused by…
- Trial name
- IAT-MEVO (NCT07668323)
- Testing
- Recombinant Tissue Plasminogen Activator (rt-PA), Intra-arterial Thrombolysis, Best Medical Management
- Where
- China
- Volunteers
- 372 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Acute Ischemic Stroke
OPtimizing REperfusion by Primary Intra-Arterial ThRomboLysis for Medium Vessel Occlusion
PEARL-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of primary intra-arterial thrombolysis in…
- Trial name
- PEARL-MeVO (NCT07137832)
- Testing
- Primary intra-arterial thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischemic Stroke, Large Vessel Occlusion
Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals
Background: Intravenous thrombolysis (IVT) combined with mechanical thrombectomy (MT) has been proven safe and effective in patients with acute ischemic stroke (AIS) of anterior circulation large vessel occlusion (LVO).
- Conditions
- Ischemic Stroke, Large Vessel Occlusion, Thrombectomy, Thrombosis
- Trial name
- DIRECT-MT (NCT03469206)
- Testing
- intra-arterial thrombectomy, Intravenous thrombolysis
- Where
- China
- Volunteers
- 656 people
- Sponsor
- Changhai Hospital
Ischemic Stroke
Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial
Patients presenting to the emergency department with acute ischaemic stroke, who are eligible for standard intravenous tPA therapy within 4.5 hours of stroke onset will be assessed for "dual target" major vessel occlusion and…
- Trial name
- EXTEND-IA (NCT01492725)
- Testing
- Intra-arterial Clot Retrieval with Solitaire device, intravenous tissue plasminogen activator (tPA)
- Where
- 9 sites in Australia, New Zealand
- Volunteers
- 70 people
- Sponsor
- Neuroscience Trials Australia
Acute Ischemic Stroke From Large Vessel Occlusion
Intra-Arterial Tenecteplase to Improve the Microvascular Hemodynamics After Mechanical Thrombectomy
This is a prospective, single-arm, open-label study to evaluate the efficacy of intra-arterial tenecteplase in improving microvascular reperfusion following successful large vessel recanalization.
- Trial name
- INTIMA-MT (NCT06904911)
- Testing
- intra-arterial tenecteplase administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Arterial Occlusive Diseases
A Dose Escalation and Safety Study of Plasmin (Human) In Acute Lower Extremity Native Artery or Bypass Graft Occlusion
The purpose of this study is to evaluate the safety of increasing doses of intra-thrombus Plasmin (Human) in acute peripheral arterial occlusion (aPAO).
- Trial name
- PRIORITY (NCT00418483)
- Testing
- Plasmin (Human) 25 mg, Plasmin (Human) 50 mg, Plasmin (Human) 75 mg
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Grifols Therapeutics LLC
Ischemic Stroke, Acute Disease
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation…
- Trial name
- ALLY II TNK (NCT06949228)
- Testing
- tenecteplase
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- ProMedica Health System
Ischemic Stroke
Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke
Patients presenting to the emergency department with acute ischemic stroke, who are are eligible for standard intravenous tPA therapy within 4.5 hours of stroke onset will be assessed for major vessel occlusion to determine their…
- Trial name
- EXTEND-IA TNK (NCT02388061)
- Testing
- Tenecteplase, Tissue Plasminogen Activator
- Where
- 18 sites in Australia, New Zealand
- Volunteers
- 202 people
- Sponsor
- Neuroscience Trials Australia
Ischemic Stroke
Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2)
Patients presenting to the emergency department with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be assessed for major vessel occlusion to determine their…
- Trial name
- NCT03340493
- Testing
- Tenecteplase
- Where
- 28 sites in Australia, New Zealand
- Volunteers
- 300 people
- Sponsor
- Neuroscience Trials Australia
Medium Vessel Occlusion Stroke (MeVO), Stroke Acute
SAIL-MEVO: Endovascular Treatment Versus Best Medical Therapy for Distal Vessel Occlusions
Patients with acute ischemic stroke caused by distal or medium vessel occlusions (MeVOs) may experience significant disability despite receiving the current standard medical treatment.
- Conditions
- Medium Vessel Occlusion Stroke (MeVO), Stroke Acute, Acute Ischemic Stroke, Cerebral Artery Occlusion
- Trial name
- SAIL MEVO (NCT07843797)
- Testing
- best medical therapy, Endovascular Treatment
- Volunteers
- 420 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Basilar Artery Thrombosis, Basilar Artery Embolism
Basilar Artery International Cooperation Study
Rationale: Recently our study group reported the results of the Basilar Artery International Cooperation Study (BASICS), a prospective registry of patients with an acute symptomatic basilar artery occlusion (BAO).
- Conditions
- Basilar Artery Thrombosis, Basilar Artery Embolism, Stroke of Basilar Artery, Stroke
- Trial name
- BASICS (NCT01717755)
- Testing
- Intra-arterial treatment
- Where
- 27 sites in Brazil, Germany and 4 more
- Volunteers
- 282 people
- Sponsor
- Erik van der Hoeven
Ischemic Stroke
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial
Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS.
- Trial name
- ALLY (NCT05172934)
- Testing
- intra-arterial tenecteplase
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ProMedica Health System
Central Retinal Artery Occlusion, Visual Field
Changes of Visual Field Defects After IAT for CRAO
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Conditions
- Central Retinal Artery Occlusion, Visual Field, Intra-arterial Thrombolysis
- Trial name
- NCT05739487
- Testing
- selective intra-arterial thrombolysis
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Stroke
Interventional Management of Stroke (IMS) III Trial
The purpose of this study is to compare two different treatment approaches to recanalization started within 3 hours of symptom onset-combined intravenous (IV) and endovascular therapy and standard intravenous (IV) rt-PA alone.
- Trial name
- IMSIII (NCT00359424)
- Testing
- IV rt-PA alone, endovascular therapy
- Where
- 71 sites in United States, Australia and 6 more
- Volunteers
- 656 people
- Sponsor
- Joseph Broderick
Acute Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Recombinant Human Tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Medium Vessel Occlusion
Medium vessel occlusion (MeVO) accounts for 20-45% of acute ischemic stroke (AIS). Although patients with MeVO often present with relatively low NIHSS scores, up to one-third remain functionally dependent at follow-up despite…
- Trial name
- MeVO-TNK Ⅱ (NCT07302854)
- Testing
- Intra-arterial Thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Xiang Luo
Stroke, Cerebrovascular Accident
Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)
The purpose of this study is to determine whether intra-arterial rt-PA within 6 hours from an ischemic stroke onset, compared with intravenous infusion of the same drug within 3 hours, increases the proportion of independent…
- Trial name
- NCT00540527
- Testing
- local interarterial recombinant tissue plasminogen activator, intravenous (IV) rt-PA
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Niguarda Hospital
Stroke, Acute Ischemic, Large Vessel Occlusion
INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy
The NEWLINE trial is a multicenter, randomized, open-label, blinded endpoint (PROBE) trial evaluating whether adjunctive low-dose intra-arterial alteplase administered immediately after successful endovascular thrombectomy…
- Conditions
- Stroke, Acute Ischemic, Large Vessel Occlusion, Thrombectomy
- Trial name
- NEWLINE (NCT07727395)
- Testing
- Alteplase, Endovascular thrombectomy
- Where
- 11 sites in Vietnam
- Volunteers
- 416 people
- Sponsor
- 115 People's Hospital
Acute Ischemic Stroke
Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke
The purpose of this study is to identify a safe and effective bolus dose of intra-arterial/intra-thrombus alfimeprase in acute ischemic stroke (AIS) 3 to 9 hours from symptom onset.
- Trial name
- NCT00499902
- Testing
- alfimeprase
- Where
- 22 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- ARCA Biopharma, Inc.
Arterial Ischemic Stroke
National Retrospective Study Of Recanalization Treatments In Pediatric Arterial Ischemic Stroke
The purpose of this study is to evaluate recanalization treatments use, safety and efficacy at the acute phase of arterial ischemic stroke in pediatric patients
- Trial name
- KID-CLOT (NCT03887143)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Acute Ischemic
Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke
Stroke is a leading cause of disability and mortality worldwide. Despite the clinical benefit of mechanical thrombectomy, 1 out of 2 patients treated are functionally independent at 90 days.
- Trial name
- IA-SUCCESS (NCT06768138)
- Testing
- Intra-arterial infusion of Alteplase
- Where
- France
- Volunteers
- 626 people
- Sponsor
- Central Hospital, Nancy, France