Clinical trials: Intra-osseous
Intraarticular Fracture, Extraarticular Fracture
Prospective Post-market Clinical Follow-up Study of the HBS 2 Resorb Mg in Patients With Intra- and Extraarticular Fractures, Pseudarthroses and Arthrodesis of Small Bones and Bone Fragments.
This study is a multi-centre, prospective, clinical observational study to evaluate the CE-marked HBS 2 Resorb Mg screws under routine conditions. The device will be used according to its intended use.
- Conditions
- Intraarticular Fracture, Extraarticular Fracture, Pseudarthrosis, Arthrosis
- Trial name
- NCT05483387
- Testing
- Treatment with HBS 2 Resorb Mg
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KLS Martin
Osteoarthritis of the Knee
A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee
The purpose of this research study is to investigate the safety and tolerability of OP-1 when it is injected into the knee joint of patients who have osteoarthritis on the knee.
- Trial name
- Knee OA (NCT00456157)
- Testing
- Intra-articular Injection of OP-1 to affected knee
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Stryker Biotech
Tibial Plateau Fracture
Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures
This study will compare two approaches to rehabilitation after surgery for a fracture of the upper part of the shinbone that involves the knee joint (tibial plateau fracture).
- Trial name
- NCT07897149
- Testing
- Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing
- Volunteers
- 86 people
- Sponsor
- Comeback Mobility Inc
Kyphosis, Spinal Fractures
Intra-operative Assessment of the Intellirod LOADPRO Spinal Rod Strain Sensor for Use During Kyphotic Corrective Surgery
The LOADPRO Study is an intra-operative, non-significant risk (NSR) case series feasibility assessment of the Intellirod LOADPRO™ System measuring spinal rod strain in long spinal kyphotic corrective constructs.
- Trial name
- LOADPRO (NCT02768675)
- Testing
- LOADPRO
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Intellirod Spine
Peri-implantitis
Reconstruction of Peri-implant Osseous Defects: A Randomized Trial
The purpose of this randomized trial was to compare reconstructive surgery of advanced peri-implant intra-osseous defects with porous titanium granules (PTG/Test) to open flap debridement (OFD/Control) in a non-submerged…
- Trial name
- NCT02406001
- Testing
- Tigran PTG, Surgical intervention
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Tigran Technologies AB
Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Arthritis
Prospective Study Measuring Clinical Outcomes of Knee Arthroplasty Using the VERASENSE™ Knee System
The primary objectives of this evaluation are: 1) To attempt to refine the current clinical understanding of "balance" 2) To determine if patients with quantifiably balanced knee joints exhibit improved clinical outcomes versus…
- Trial name
- NCT01469299
- Where
- 8 sites in United States
- Volunteers
- 285 people
- Sponsor
- Orthosensor, Inc.
Spinal Cord Injuries
Safety and Efficacy of Autologous Bone Marrow Stem Cells in Treating Spinal Cord Injury
The projected data related to the burden of spinal cord injuries induced limb paralysis in India is quite alarming. This is attributed to the rapid industrialization and economical development in the country.
- Trial name
- ABMST-SCI (NCT01186679)
- Testing
- laminectomy, Intrathecal
- Where
- India
- Volunteers
- 12 people
- Sponsor
- International Stemcell Services Limited
Graft-vs-Host Disease
Safety Study of Homeo-GH (Bone Marrow Derived Clonal Mesenchymal Stem Cell) to Treat Acute/Chronic Graft Versus Host Disease (GVHD)
Official Title: Five-Week, Multi-center, Phase I Clinical Trial to Evaluate Safety of Homeo-GH after Intra Venus Administration for the Treatment of Graft versus Host Disease Patients Sponsor: HomeoTherapy Co.,Ltd Study Design…
- Trial name
- Homeo-GH (NCT01318330)
- Testing
- Homeo-GH
- Where
- 4 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- HomeoTherapy Co., Ltd
Prostate Cancer
Safety Study of Autologous Dendritic Cells Injected Into the Prostate After Cryoablation for Advanced Prostate Cancer
The purpose of this study is to determine if the intra-tumoral injection of a subject's own dendritic cells after cryotherapy of the prostate is a safe and effective treatment for advanced prostate cancer.
- Trial name
- CRITICAL (NCT00753220)
- Testing
- VDC2008, Cyclophosphamide
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Bostwick Laboratories
Lumbar Spine Disease, Lumbar Spondylolisthesis
OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar…
- Conditions
- Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis
- Trial name
- SELECT (NCT05405374)
- Testing
- OSTEOAMP, Infuse
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bioventus LLC
Post-Menopausal Osteoporosis
Intra-venous Zoledronic Acid Once Yearly
The study will assess the real life effectiveness of zoledronic acid in the management of patients with osteoporosis over 4 years of treatment.
- Trial name
- IVORY (NCT00984893)
- Testing
- zoledronic acid, Any oral bisphosphonates marketed in Canada
- Where
- 3 sites in Canada
- Volunteers
- 1,551 people
- Sponsor
- Novartis Pharmaceuticals
Peri-Implantitis
Efficacy of Synthetic Bone Graft for Treatment of Peri-implantitis
Single arm study to evaluate the effectiveness of treatment approach using a new moldable beta-tricalcium phosphate(TCP) bone graft material and polylactide membrane in peri-implantitis.
- Trial name
- NCT03213210
- Testing
- easy-graft CLASSIC (beta-Tricalcium Phosphate)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sunstar Americas
Paroxysmal Nocturnal Hemoglobinuria
Dose Escalation of BCX10013 in Participants with Paroxysmal Nocturnal Hemoglobinuria (PNH)
This is a multicenter, open-label, intra-subject, dose escalation study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and therapeutic potential of BCX10013 in participants with PNH.
- Trial name
- NCT06100900
- Testing
- BCX10013
- Where
- 4 sites in Malaysia, South Africa
- Volunteers
- 8 people
- Sponsor
- BioCryst Pharmaceuticals
Acromegaly
Safety and Biological Activity of C2L-OCT-01 PR in Acromegalic Patients
The purpose of this study is to assess the safety profile of a new prolonged release formulation of octreotide acetate, C2L-OCT-01 PR, administered intra muscularly every 4, 5 or 6 weeks in acromegalic patients.
- Trial name
- NCT00642421
- Testing
- C2L-OCT-01 PR, 10 or 20 mg, C2L-OCT-01 PR, 20 mg
- Where
- 10 sites in United States, Belarus and 4 more
- Volunteers
- 40 people
- Sponsor
- Ambrilia Biopharma, Inc.
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Arthritis, Psoriatic
Evaluation of Allocetra by Intra-articular Injection for the Treatment of Psoriatic Arthritis
This is an open label study to evaluate the safety and initial efficacy of intra-articular administration of Allocetra in patients with Psoriatic Arthritis (PsA).
- Trial name
- NCT06522035
- Testing
- Allocetra
- Where
- 4 sites in Israel
- Volunteers
- 5 people
- Sponsor
- Enlivex Therapeutics Ltd.
Intra-Articular or Extra-Articular Distal Humerus Fracture, Distal Humerus Fracture
Clinical Outcomes After Treatment of Distal Humerus Fractures With the LORRAINE 2.5/3.5 mm Distal Humerus System
Distal humerus fractures are fractures of the lower part of the upper arm bone near the elbow. These fractures often require surgery using plates and screws to stabilize the bone while it heals.
- Trial name
- NCT07774091
- Testing
- LORRAINE 2.5/3.5 mm Distal Humerus System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Bonebridge AG
Sacro Iliac Joint Pain, Sacro-iliac Joints
Posterior-Inferior Intra-articular Cortical Piercing Titanium Implant for Sacroiliac Joint Fusion: Evaluation of Safety and Effectiveness Outcomes
The purpose of this study is to evaluate outcomes in patients treated with iFuse INTRA Ti for chronic SI joint pain.
- Conditions
- Sacro Iliac Joint Pain, Sacro-iliac Joints, Sacroiliac Disorder, Sacroiliac Joint Dysfunction
- Trial name
- PIERCE (NCT07565545)
- Testing
- iFuse INTRA Ti Implant System
- Volunteers
- 120 people
- Sponsor
- SI-BONE, Inc.
Osteoarthritis, Knee, Arthritis, Rheumatoid
Evaluation of Medium Cross-linked Polyethylene With and Without Vitamin E for Total Knee Arthroplasty
Prospective, randomized, single-blind, multinational, long-term study for the evaluation of the clinical outcome, oxidation profile and wear analysis of medium cross-linked Polyethylene with and without Vitamin E for total knee…
- Conditions
- Osteoarthritis, Knee, Arthritis, Rheumatoid, Intra-Articular Fractures, Joint Instability
- Trial name
- VIKEP (NCT04618016)
- Testing
- UHMWPE with Vitamin E, UHMWPE without Vitamin E
- Where
- 8 sites in France, Germany
- Volunteers
- 605 people
- Sponsor
- Aesculap AG