Clinical trials: Intra-osseous
Dental Implant Bone Loss, Peri-Implant Health
The Aim of the Study Will be Clinically and Radio Graphically Comparison of Two Implant Designs Used to Treat Atrophied Mandible . Implant Design Comparison Will Done for Implant Stability,Peri-implant Soft Tissue Health Changes and Bone Changes .Patients Will be Divided Randomly Into Two Group
The aim of the present study will be clinical and radio graphical comparison of four basal and compressive implant designs will be installed in the interforamina area of atrophied edentulous mandible and immediately loaded by…
- Trial name
- Implants types (NCT07588789)
- Testing
- Basal Dental implant, Compressive Dental implant
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Mansoura University
Peri-implant Mucositis, Peri-Implantitis
Experimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty
This controlled clinical trial will assess clinically, immunologically, and microbiologically the healing of experimental peri-implant mucositis (PIM) lesions in implants treated previously with implantoplasty (IP) compared to…
- Trial name
- NCT06063876
- Testing
- Induction of experimental peri-implant mucositis, Resolution of experimental peri-implant mucositis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Edentulous Alveolar Ridge
Long-term Follow up of Mucosal Tissue Height Influence on Peri-implant Bone Levels.
Our study looks into how the thickness of the gum tissue affects the health of the bone around dental implants over ten years. We include 59 people and divide them into three groups based on their gum tissue thickness.
- Trial name
- NCT06302322
- Testing
- Thin Tissues, Thick Tissues, Surgically augmented thin tissues
- Where
- Lithuania
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Edentulism
Patient Satisfaction and Oral Health-Related Quality of Life of Quadrilateral Versus Bilateral Linear Bar Designs for Four Implant Implant-Assisted Complete Mandibular Overdenture Regarding Peri-Implant Crestal Bone Loss
For this study, twenty patients were selected, and participants were randomly divided into two groups using random numbers produced in an Excel spreadsheet.
- Trial name
- NCT06673173
- Testing
- Implant
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Implant Complication
Impact of Implant Insertion Torque on Peri-implant Bone Level.
Observational study with one single arm. The purpose of this study was to evaluate the impact of the insertion torque and of the implant stability on the marginal bone level changes for dental implants placed into healed ridges.
- Trial name
- NCT04769934
- Testing
- Penguin RFA
- Where
- Switzerland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Dental Anaesthesia
Intraosseous Anesthesia Versus Mandibular Nerve Block in Children
The aim of the current study is to compare a new computerized intra-osseous injection system to the conventional inferior alveolar nerve block in children
- Trial name
- NCT05193487
- Testing
- inferior alveolar nerve block, intra-osseous mandibular anaesthesia
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Health Quality of Life (OHQoL) Was Assessed, the Effect of Surface Roughness on Crestal Bone Remodelling
Comparison of Implants With Different Implant Surfaces.
This study looks at how the surface texture of dental implants affects the surrounding bone and the overall gum health over time. It compares two types of implant surfaces: one partially smooth and one slightly rough.
- Conditions
- Oral Health Quality of Life (OHQoL) Was Assessed, the Effect of Surface Roughness on Crestal Bone Remodelling, The Effect of Surface Roughness on Peri-implant Health
- Trial name
- NCT07087717
- Testing
- Split-Mouth Placement of an implant with a moderately rough surface (DCC)., Split-Mouth Placement of an implant with a hybrid surface (MSC).
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Ghent
Dental Implants, Peri-Implantitis
Increased Peri-implant Keratinized Mucosal Thickness at Different Operative Times
Keratinized mucosa, which is composed of free gingiva and attached gingiva, is a barrier against bacterial invasion in oral cavity and provides good tissue sealing for periodontal environment.
- Trial name
- NCT04683991
- Testing
- Subepithelial connective tissue graft
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Femoral Neck Fractures
Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty
This study is a double-blinded placebo-controlled clinical trial evaluating the efficacy of 1 gram of topically applied tranexamic acid vs. saline placebo for the reduction of transfusion following hip hemiarthroplasty surgery.
- Trial name
- NCT02664909
- Testing
- Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- UConn Health
Degenerative Disc Disease, Facet Joint Syndrome
Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Degenerative Disc Disease and Facet Joint Syndrome
Autologous Platelet-Rich-Plasma (PRP) represents a regenerative therapy that has gained remarkable ground in the field of orthopaedics in recent years.
- Trial name
- NCT04816747
- Testing
- Autologous PRP
- Volunteers
- 50 people
- Sponsor
- Stylianos Kapetanakis
Periodontal Bone Loss
The Use of Chlorhexidine Gel Following EDTA Root Surface Etching as an Adjunctive to Open Flap Debridement in Treating Intra-Bony Defects
SUMMARY Chronic periodontitis is regarded as an inflammatory disease that affects the supporting tissues of teeth which could lead to bone destruction.
- Trial name
- NCT05170932
- Testing
- CHX gel 2 % + 24% EDTA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tooth Loss in the Anterior Maxilla, Alveolar Bone Resorption
Peri-Implant Hard and Soft Tissue Changes After Immediate Implant Placement With Socket Shield and Immediate Restoration Versus Early Implant Placement in the Esthetic Zone
This randomized controlled clinical trial aims to compare peri-implant hard and soft tissue dimensional changes following immediate implant placement with the socket shield technique and immediate restoration versus early type II…
- Conditions
- Tooth Loss in the Anterior Maxilla, Alveolar Bone Resorption, Partial Edentulism of the Maxilla
- Trial name
- NCT07468760
- Testing
- Socket Shield, Early Implant Placement
- Where
- United Arab Emirates
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Critical Limb Ischemia (CLI)
Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System
This is a prospective, double-blinded, randomized, placebo-controlled, multi-center, pivotal clinical study in which subjects are evaluated for prevention of major limb amputation in the treatment of non-reconstructable…
- Trial name
- CLIRST III (NCT02538978)
- Testing
- Autologous Bone Marrow Concentrate (aBMC)
- Volunteers
- 224 people
- Sponsor
- Cesca Therapeutics, Inc.
Tibial Fractures
Prosthesis Versus Osteosynthesis in Proximal Tibia Fractures
The aim of this study is to compare knee function and pain one year after treatment of intra-articular proximal tibia fracture using either osteosynthesis with a locking plate (ORIF) or primary total knee replacement (TKR) in…
- Trial name
- POSITIF (NCT03172715)
- Testing
- Locking plate, TKR
- Where
- 8 sites in Finland
- Volunteers
- 98 people
- Sponsor
- Central Finland Hospital District
Arthritis, Rheumatoid, Arthritis, Psoriatic
Study of Intra-articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects
The 13G01 clinical trial is a Phase I/II dose escalation study designed to be conducted in adults with inflammatory arthritis who have persistent moderate or severe swelling in one or more joints, without a disease severe enough…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Ankylosing Spondylitis
- Trial name
- NCT00126724
- Testing
- tgAAC94 gene therapy vector
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Targeted Genetics Corporation
Abdominal Cancer
Vessel- and Bone-based Ultrasound Registration
In this study we aim to develop an automatic artery and bone segmentation algorithm, which is required for future clinical implementation of US registration for surgical navigation.
- Trial name
- NCT05637346
- Testing
- Intra-operative ultrasound measurement
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- The Netherlands Cancer Institute
Acromegaly, Growth Hormone Deficiency
Peripheral Metabolic Effects of Somatostatin
The aim of this study is to investigate peripheral effects of Somatostatin on glucose metabolism and growth hormone (GH) signalling in healthy men. Eight subjects will be enrolled.
- Conditions
- Acromegaly, Growth Hormone Deficiency, Diabetes
- Trial name
- NCT01062529
- Testing
- Somatostatin
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ankle Fractures, Intra-Articular Fractures
Prevention of Posttraumatic Osteoarthritis After Acute Intraarticular Fractures
Intra-articular fracture is a very common fracture. The only method to treat these fractures is surgery with plate and screws followed by rehabilitation.
- Conditions
- Ankle Fractures, Intra-Articular Fractures, Osteoarthritis
- Trial name
- NCT03769909
- Where
- Denmark
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Osteoporosis, Postmenopausal
Peri-implant Bone Changes in Post-menopausal Osteoporotic Women
This is a prospective case series study aiming to evaluate the effect of post-menopausal osteoporosis on the jaw bone around dental implants with a modified titanium surface.
- Trial name
- NCT02884401
- Testing
- Dental implant placement (Straumann® Bone Level Tapered, BLT, Roxolid® SLActive®)
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Queen Mary University of London
Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM)
The Efficacy and Safety of REX-001 to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM
This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 4.
- Conditions
- Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM), Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03111238
- Testing
- REX-001
- Where
- 15 sites in Czechia, Germany and 4 more
- Volunteers
- 3 people
- Sponsor
- Ixaka Ltd