Clinical trials: Intracerebral Hemorrhage Basal Ganglia
Intracerebral Hemorrhage Basal Ganglia
Efficacy and Safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage
To compare the efficacy and safety of neuroendoscopic hematoma removal and standard conservative treatment for patients with spontaneous supratentorial deep intracerebral hemorrhage.
- Trial name
- NESICH (NCT05539859)
- Testing
- Endoscopic surgery, Medical management
- Where
- 4 sites in China
- Volunteers
- 560 people
- Sponsor
- Southwest Hospital, China
Stroke, Intracerebral Hemorrhage Basal Ganglia
Neuroendoscopic Hematoma Evacuation Combined With Methylprednisolone Sodium Succinate in the Treatment of Basal Ganglia Intracerebral Hemorrhage at the Early Stage
The aim of this trial is to investigate whether neuroendoscopic hematoma evacuation combined with early use of methylprednisolone sodium succinate can improve the efficacy and safety in the treatment with that of simple…
- Conditions
- Stroke, Intracerebral Hemorrhage Basal Ganglia, Methylprednisolone, Surgery
- Trial name
- NEMP-BGH (NCT06924983)
- Testing
- Simple neuroendoscopic hematoma evacuation, Neuroendoscopic hematoma evacuation combined with sodium methylprednisolone succinate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yong Jiang
Basal Ganglia Intracerebral Hemorrhage
Minimally Invasive Neuroendoscopic Ultra-Early Targeted ICH Evacuation
MINUTE is a prospective, multi-center, randomized, controlled, blinded assessor, adaptive enrichment design, clinical trial. Eligible patients with spontaneous BGH ≥20 mL will be randomized 1:1 to either minimally invasive…
- Trial name
- MINUTE (NCT07260916)
- Testing
- Endoscopic ICH evacuation, Standard Medical Treatment
- Where
- 44 sites in United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage Basal Ganglia, Intracerebral Haemorrhage
Minimally Invasive Surgery For Patients With Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the safety and effectiveness of minimally invasive surgery (MIS) compared with standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Trial name
- MISDIH (NCT07234955)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Huynh Quoc Huy
Basal Ganglia Haematoma
Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation
Spontaneous cerebral hemorrhage is one of the main causes of death and disability all over the world, accounting for 20%-30% of all cerebrovascular diseases.
- Trial name
- SOITBE (NCT03957707)
- Testing
- stereotactic surgery plus thrombolysis, Guideline-based standard medical management
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage--Small Hemorrhage Evacuation (MIRACLE-S)
The objective of this study is to determine whether minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared to usual care, leads to superior functional recovery as measured by utility-weighted modified…
- Trial name
- MIRACLE-S (NCT06688162)
- Testing
- Usual Care, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation (scMIS)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Capital Medical University
Atrial Fibrillation, Intracerebral Hemorrhage
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation
Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain.
- Trial name
- PRESTIGE-AF (NCT03996772)
- Testing
- Apixaban Oral Tablet, Dabigatran, Edoxaban Tablets
- Where
- 64 sites in Austria, France and 4 more
- Volunteers
- 319 people
- Sponsor
- Imperial College London
Basal Ganglia Hemorrhage
Stereotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation II
Spontaneous cerebral hemorrhage is one of the main causes of death and disability all over the world, accounting for 20%-30% of all cerebrovascular diseases.
- Trial name
- SOITBE II (NCT04172376)
- Testing
- Minimally invasive puncture aspiration plus rt-PA, Conservative medical treatment
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
Minimally Invasive Surgery for Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the real-world effectiveness and safety of minimally invasive surgery (MIS) versus standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Conditions
- Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage, Basal Ganglia Hemorrhage
- Trial name
- MIS-DEEP ICH (NCT07710313)
- Testing
- Minimally Invasive Surgery (MIS), Standard medical treatment (SMT)
- Volunteers
- 300 people
- Sponsor
- Tam Anh Research Institute
Intracerebral Hemorrhage, Cerebral Hemorrhage
MIECH: The Minimally Invasive Endoscopic Surgery With the Axonpen System for Spontaneous Intracerebral Hemorrhage
The primary objective of this trial is to provide preliminary safety data of minimally invasive endoscopic surgery using the Axonpen™ system for spontaneous intracerebral hemorrhage (ICH).
- Conditions
- Intracerebral Hemorrhage, Cerebral Hemorrhage, Intracranial Hemorrhage, Basal Ganglia Hemorrhage
- Trial name
- NCT04839770
- Testing
- Axonpen system
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Clearmind Biomedical Inc.
Intracerebral Haemorrhage, Intraventricular
Safety and Suitability of Supplementing Early MIP Surgery (MIPS) of ICH With Pioglitazone
This is an exploratory single-center prospective study of 20 subjects with primary basal ganglia ICH who will receive early MIPS in combination with perioperative pioglitazone treatment.
- Trial name
- ENRICHPLUS (NCT05582707)
- Testing
- Pioglitazone 15mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Maryland, Baltimore
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Basal Ganglia Hemorrhage
A Trial for Minimally Invasive Neurosurgery With AI-assisted Robotic Guidance for Moderate Basal Ganglia Hemorrhage (RAINBOW-MBH)
A nationwide, prospective, multicenter randomized controlled clinical trial to evaluate the therapeutic effects of the fiber tract-based artificial intelligence (AI) Robot Guiding System on the perioperative and long-term…
- Trial name
- RAINBOW-MBH (NCT06465719)
- Testing
- Minimally invasive basal ganglion hematoma evacuation with Tract-based AI Robot Guiding System, Patients will be managed with guideline-based medications
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage-- Large Hemorrhage Evacuation (MIRACLE-L)
To determine if minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared with any other neurosurgical technique that includes open craniotomy, small skull window microsurgery , and endoscopic surgery, is at…
- Trial name
- MIRACLE-L (NCT06688201)
- Testing
- Other neurosurgical techniques, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage
Rapid Evacuation and Access of Cerebral Hemorrhage Registry
The goal of this observational study is to quantify the real-world effect of minimally invasive surgery (MIS) in patients with acute spontaneous supratentorial intracerebral hemorrhage.
- Trial name
- REACH (NCT07651631)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Emory University
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Basal Ganglia Hemorrhage
Minimally Invasive Treatment of Hypertensive Basal Ganglia Hemorrhage by Transfrontal Keyhole Neuroendoscopy
To compare the prognosis of patients with hypertensive intracerebral hemorrhage treated by two different surgical methods, and to clarify the therapeutic effect of minimally invasive surgery, so as to find a better surgical…
- Trial name
- NCT04958525
- Testing
- Keyhole neuroendoscopic transfrontal ultrasound-guided hematoma removal, Small bone window craniotomy for hematoma removal under microscope
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Intracranial Hemorrhages, Cerebrovascular Disorders
Minimally Invasive Surgery and rhTNK-tPA for Intracerebral Hemorrhage Evacuation
The purpose of this trial is to determine the safety of using a combination of robot-assisted stereotactic puncture and clot lysis with rhTNK-tPA to remove intracerebral hemorrhage (ICH) and to provide dose evidence for a phase…
- Conditions
- Intracranial Hemorrhages, Cerebrovascular Disorders, Cerebral Hemorrhage, Hemorrhage
- Trial name
- NCT06668441
- Testing
- Minimally invasive surgery plus low-dose rhTNK-tPA group, Minimally invasive surgery plus medium dose rhTNK-tPA group, Minimally invasive surgery plus high dose rhTNK-tPA group
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Chronic Stroke
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
The main purpose of the current studies is to evaluate the safety and tolerability of psilocybin in patients with chronic stroke.
- Conditions
- Stroke, Chronic Stroke, Intracerebral Haemorrhage, Intracerebral Haemorrhage (ICH)
- Trial name
- PHATHOM (NCT07053917)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University