Clinical trials: Intracranial Arterial Aneurysm
Intracranial Aneurysm
Reduction of Microembolism After the Intervention Surgery of Intracranial Aneurysms by Administration of Tirofiban
The goal of this clinical trial is to investigate whether intravenous injection of tilofiban can reduce microembolism in patients with unruptured intracranial aneurysms after Stent-Assisted Coil Embolization.The main questions it…
- Trial name
- NCT05841147
- Testing
- Tirofiban, normal saline
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Lu Hua
Cerebral Aneurysm
Hydrogel Endovascular Aneurysm Treatment Trial
This research study is being done to test the effectiveness of a new generation FDA approved device for treating aneurysms compared to the current standard device for endovascular aneurysm treatment which is bare platinum coils.
- Trial name
- HEAT (NCT01407952)
- Testing
- HydroCoil Embolic System, Control (bare platinum coils)
- Where
- 44 sites in United States, Canada
- Volunteers
- 600 people
- Sponsor
- Northwestern University
Intracranial Aneurysm
Perioperative Neuroprotection of Stellate Ganglion Block
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
- Trial name
- NCT02275247
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Vascular; Lesion, Central Nervous System, Brain Tumor
Intraoperative Fluorescence With Augmented Reality
This is a study looking at a new way to evaluate vascular problems or tumors in brain surgery patients using a standard \& approved intravenous dye and augmented reality.
- Conditions
- Vascular; Lesion, Central Nervous System, Brain Tumor, Cerebral Aneurysm, Cerebral AVM
- Trial name
- NCT03888014
- Testing
- GLOW800, indocyanine green (ICG)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Cedars-Sinai Medical Center
Intracranial Aneurysm
Effect of Different Heparinization Schemes on Prognosis of Intracranial Aneurysm
The goal of this clinical trial is to compare intracranial aneurysm patients. The main question it aims to answer are: Which heparinization regimen is most beneficial to patients during surgery for intracranial aneurysms.
- Trial name
- EODHS-IA (NCT05749393)
- Testing
- Heparin sodium
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Brain Aneurysm, Intracranial Hemorrhages
Outcome Study of the Pipeline Embolization Device With Vantage Technology in Unruptured Aneurysms
In this project the investigators study the safety and efficacy of the pipeline embolization device with vantage technology in treatment of unruptured brain aneurysms
- Conditions
- Brain Aneurysm, Intracranial Hemorrhages, Stroke
- Trial name
- PEDVU (NCT05626504)
- Testing
- Pipeline Embolization Device with Vantage Technology
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Subarachnoid Hemorrhage, Cerebral Aneurysm
Clevidipine for Vasospasm After Subarachnoid Hemorrhage (SAH)
Vasospasm occurs frequently after aneurysmal subarachnoid hemorrhage and can lead to strokes. The investigators will investigate if infusion of a novel drug, clevidipine, will decrease vasospasm during the infusion and post…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Aneurysm, Vasospasm, Intracranial
- Trial name
- CLEVAS (NCT02011321)
- Testing
- clevidipine
- Where
- United States
- Sponsor
- Henry Ford Health System
Intracranial Aneurysm
Prevalence and Factors Associated With the Occurrence of Depression Six Months After an Endovascular Treatment of Intracranial Aneurysm
During the last decade, the embolization has become the treatment of choice for ruptured intracranial aneurysms, to improve the neurological outcome of patients.
- Trial name
- DEP-AIC (NCT02866812)
- Testing
- questionnaires assessing the state of fatigue, depression and anxiety
- Where
- France
- Volunteers
- 133 people
- Sponsor
- CHU de Reims
Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation
Transvenous Approach for the Treatment of Cerebral Arteriovenous Malformations
A new endovascular route for the treatment of brain AVMs may be possible in some cases: Trans-Venous Embolization (TVE). The technique uses microcatheters to navigate to the draining veins of AVM, to reach and then fill the AVM…
- Conditions
- Arteriovenous Malformations, Cerebral, Unruptured Brain Arteriovenous Malformation, Ruptured Brain Arteriovenous Malformation
- Trial name
- TATAM (NCT03691870)
- Testing
- Standard Trans-Arterial Embolization (TAE), Trans-Venous Embolization (TVE)
- Where
- 9 sites in Canada, France
- Volunteers
- 77 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysm, Muscular Atrophy
Minipterional Versus Pterional Craniotomy
This randomized prospective study was designed to compare the clinical, functional and aesthetic results of two surgical techniques for microsurgical clipping of anterior circulation aneurysms
- Trial name
- NCT01872741
- Testing
- Minipterional craniotomy, Pterional craniotomy
- Volunteers
- 58 people
- Sponsor
- University of Sao Paulo General Hospital
Efficacy, Self, Hemodynamic Instability
Pipeline Embolization for Intracranial Aneurysms
This study collected the clinical, laboratory, and imaging data from patients with intracranial aneurysms, who underwent Pipeline implantation.
- Conditions
- Efficacy, Self, Hemodynamic Instability, Stenosis, Aneurysm, Intracranial
- Trial name
- NCT06446778
- Testing
- Pipeline embolization device with or without shield technique
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Zhujiang Hospital
Unruptured Cerebral Aneurysm
Remote Ischemic PreConditioning (RIPC)
The purpose of this study is to learn about protecting the brain from low blood flow (ischemia) with limb preconditioning. From human studies the investigators know that the brain can be protected from dangerous low blood flow by…
- Trial name
- NCT03814850
- Testing
- Standard Manual Aneroid Sphygmomanometer
- Where
- 2 sites in United States
- Sponsor
- Sebastian Koch
Self Efficacy, Medical Device Complication
Chinese Registry of Assisted Embolization for Unruptured Wide Necked Intracranial Aneurysm Using LVIS Stent
This study aims to investigating the efficacy and safety of low profile visualized intraluminal support (LVIS) stents for the treatment of unruptured intracranial saccular aneurysms.
- Trial name
- CRANIAL-1 (NCT02830373)
- Testing
- LVIS stents
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Intracranial Aneurysm
CATCH [Short Name for: Coil Application Trial in China]
The scope of this trial is the collection and analysis of effectiveness and safety endpoints, related to the use of the MicroPort NeuroTech Coil Embolization System in the treatment of intracranial aneurysms.
- Trial name
- CATCH (NCT02990156)
- Testing
- Coil Embolization System, Cotrol device from Medronic
- Where
- China
- Volunteers
- 334 people
- Sponsor
- MicroPort NeuroTech Co., Ltd.
Cerebral Aneurysm
Ticagrelor vs Clopidogrel for Platelet Inhibition in Stenting for Cerebral Aneurysm
Part of interventional neuroradiology procedures for the treatment of selected cerebral aneurysms are now based on stenting. To reduce thromboembolic events, dual antiplatelet therapy (APT) combining aspirin and clopidogrel is…
- Trial name
- TIC-TAC (NCT02675205)
- Testing
- Clopidogrel, Ticagrelor, aspirin
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral Aneurysm
DELTA Trial: Does Embolization With Larger Coils Lead to Better Treatment of Aneurysms Trial
Endovascular treatment with platinum coils is safe and effective in preventing rebleeding of intracranial aneurysms. Unfortunately, endovascular treatment of aneurysms with coils has been associated with incomplete occlusion at…
- Trial name
- DELTA (NCT01943591)
- Testing
- Endovascular coiling with standard 10-caliber platinum coils or 15-caliber platinum coils
- Where
- 15 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysm
An Early Warning Model of Unfavorable Outcomes Following Endovascular Interventional Treatment of Intracranial Aneurysm
Endovascular treatment has become one of the primary treatment methods for intracranial aneurysms. The unfavorable outcomes during follow-up included aneurysm recurrence and long-term incomplete-occlusion, which would bring a…
- Trial name
- NCT06364293
- Testing
- Observational design does not include interventional behavior.
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm, Cerebrovascular Stenosis
Hybrid Operating Treatment of Coexistence of Intracranial Aneurysms and Cerebrovascular Stenosis
To evaluate the clinical benefits and risks of hybrid operating techniques in management of intracranial aneurysms with coexistence of atherosclerotic intracranial arterial stenosis.
- Conditions
- Intracranial Aneurysm, Cerebrovascular Stenosis, Atheroscleroses, Cerebral
- Trial name
- HOT-CIACS (NCT03204435)
- Testing
- Microsurgical aneurysmal operating techniques, endovascular techniques for cerebrovascular stenosis, endovascular techniques for intracranial aneurysms
- Where
- China
- Volunteers
- 196 people
- Sponsor
- liuxingju
Cerebral Aneurysm
Framing Eighteen Coils in Cerebral Aneurysms Trial
This trial is being conducted in order to compare angiographic outcomes in patients receiving 0.014-0.0155" platinum framing and filling coils (larger diameter coils) versus those treated solely with coils less than 0.014" (with…
- Trial name
- FEAT (NCT01655784)
- Testing
- Coil Embolization with larger Diameter Coils, Coil Embolization with Standard Diameter Coils
- Where
- 24 sites in United States
- Volunteers
- 651 people
- Sponsor
- Vanderbilt University Medical Center
Cerebral Aneurysm
Multidimensional Evaluation of Patients With Ruptured or Unruptured Cerebral Aneurysm Undergoing Endovascular or Surgical Treatment
Cerebral aneurysms are common changes in intracranial angioarchitecture. Unruptured aneurysms are increasingly identified thanks to the imaging techniques used in daily clinical practice.
- Trial name
- NCT05713825
- Testing
- Endovascular embolization or surgery
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS