Clinical trials: Intracranial Arterial Diseases
Cerebral Arterial Disease
Normal Values of Brain Oxygenation
New technology allows non-invasive monitoring of brain oxygenation (Near-Infrared-Spectroscopy). However, there are no large series of normal values in various adult age groups.
- Trial name
- NCT00512447
- Where
- Switzerland
- Volunteers
- 171 people
- Sponsor
- University Hospital, Basel, Switzerland
Moyamoya, Stroke
The Role of Cerebral Hemodynamics in Moyamoya Disease
The purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.
- Trial name
- NCT00629915
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Unruptured Intracranial Aneurysm, Intracranial Aneurysm
Surveillance Versus Treatment of Unruptured Intracranial Aneurysms of Fortuitous Discovery
The goal of this clinical trial is to determine whether a watchful waiting strategy with imaging surveillance is superior to immediate aneurysm treatment in adults with incidentally discovered unruptured intracranial aneurysms…
- Trial name
- STAF (NCT07817511)
- Testing
- Clinical and imaging surveillance, Endovascular or neurosurgical aneurysm treatment
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke
A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke
This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic…
- Trial name
- NCT02928393
- Testing
- Basmisanil
- Where
- 13 sites in France, Spain
- Volunteers
- 5 people
- Sponsor
- Hoffmann-La Roche
CVD
Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting
Argatroban is a selective thrombin inhibitor, and previous study had suggested that argatroban use post PCI could potentially prevent reocclusion.
- Trial name
- APORIAS (NCT01163604)
- Testing
- Argatroban, non-argatroban treated group
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Jinling Hospital, China
Neurodegenerative Diseases, Alzheimer Disease
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH).
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Frontotemporal Dementia, Lewy Body Disease
- Trial name
- DEGERWD (NCT06209515)
- Where
- Finland
- Volunteers
- 61,292 people
- Sponsor
- Kuopio University Hospital
Aneurysm, Cerebral
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage and neurologic complications.
- Trial name
- NCT03823482
- Testing
- Lidocaine
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Clinical Hospital Centre Zagreb
Intracranial Aneurysms
Contrast-free Magnetic Resonance Angiography (MRA) at 3.0 T for Intracranial Aneurysm Detection
The Chinese Cerebral Aneurysms Survey is a continuing prospective study to evaluate the effectiveness of unenhanced, three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) with volume rendering (VR) at 3-T…
- Trial name
- NCT01031147
- Testing
- Examination
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Unruptured Intracranial Aneurysms, Cerebrovascular Event
Efficacy and Safety of Methylprednisolone After Flow-Diverter Stent Implantation in Unruptured Intracranial Aneurysms
Study Title: Testing Methylprednisolone to Prevent Strokes After a Stent Procedure for Brain Aneurysms What is the purpose of this study? This study aims to find out if a short course of a steroid medicine called…
- Conditions
- Unruptured Intracranial Aneurysms, Cerebrovascular Event, Hemorrhagic Stroke, Methylprednisolone
- Trial name
- NCT07353749
- Testing
- Methylprednisolone (Injectable Form)
- Where
- China
- Volunteers
- 864 people
- Sponsor
- Duan Chuanzhi
Motor Evoked Potential Monitoring, General Anesthesia
Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is…
- Conditions
- Motor Evoked Potential Monitoring, General Anesthesia, Neurosurgery, Brain Tumor
- Trial name
- NCT01690364
- Testing
- MEP monitoring with continuous infusion of vecuronium during general anesthesia, MEP monitoring with continuous infusion of cisatracurium during general anesthesia
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Samsung Medical Center
Carotid Stenosis
Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting
The purpose of this study is to evaluate the safety and efficacy of the TriActiv® ProGuard™ System when used during a stent placement in a blockage within the carotid artery in patients considered to be at high risk for…
- Trial name
- NCT00395785
- Testing
- Carotid Stent Implantation, Embolic Protection
- Where
- 34 sites in United States, Germany
- Volunteers
- 400 people
- Sponsor
- Kensey Nash Corporation
Hereditary Hemorrhagic Telangiectasia
Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research.
- Trial name
- BVMC6203 (NCT01158807)
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 2,272 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Management of CSDH With or Without EMMA- a Randomized Control Trial
EMMA-Can is a prospective randomized open-label, blinded end point (PROBE) study, that will assess the recurrence risk and safety of embolization of the middle meningeal (EMMA) when added to standard of care treatment (surgical…
- Trial name
- EMMA-Can (NCT04750200)
- Testing
- Embolization of the Middle Meningeal Artery
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- University of Manitoba
Ischemic Stroke, Acute
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment.
- Trial name
- TANDEM-1 (NCT00777140)
- Testing
- Deferoxamine
- Where
- 4 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Cerebrovascular Event, Stent Stenosis
Atorvastatin Pretreatment in Cerebrovascular Events (APICES) After Flow Diverter Implantation
APICES trial is an investigator-initiated, multicenter, multicenter, randomized, double-blind, placebo-controlled clinical trial that plans to enroll 396 patients with a 1-year follow-up, including a neurovascular imaging…
- Conditions
- Cerebrovascular Event, Stent Stenosis, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT06308952
- Testing
- Atorvastatin 20mg
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Duan Chuanzhi
Intracranial Aneurysm
Perioperative Neuroprotection of Stellate Ganglion Block
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
- Trial name
- NCT02275247
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Cerebral Aneurysm
Acupoint Stimulation and Cranial Endovascular Treatment
In this prospective randomized controlled trial, the subjects will be assigned to group transcutaneous electrical acupoint stimulation (TEAS) and group control (no intervention).
- Trial name
- ASSET (NCT05413460)
- Testing
- transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Zhihong LU
Vascular Dementia
The Clinical Trial of Chinese Herbal Medicine (SaiLuoTong) Capsule
As a traditional Chinese medicine compound, SaiLuoTong capsule is proven to have beneficial effects on learning and memory ability in animal models of vascular dementia (VaD).
- Trial name
- NCT03789760
- Testing
- SaiLuoTong capsule
- Where
- 29 sites in China
- Volunteers
- 493 people
- Sponsor
- Shineway Pharmaceutical Co.,Ltd
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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