Clinical trials: Intracranial Atherosclerotic Disease
Intracranial Atherosclerosis, Intracranial Arterial Stenosis
EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease
ERSIAS IIb is a multicenter randomized controlled trial, with a Phase IIb design, to find out whether encephaloduroarteriosynangiosis (EDAS), a type of indirect surgical revascularization of the brain, added to intensive medical…
- Conditions
- Intracranial Atherosclerosis, Intracranial Arterial Stenosis, Ischemic Stroke
- Trial name
- ERSIAS IIb (NCT07864649)
- Testing
- Encephaloduroarteriosynangiosis (EDAS), Intensive medical management
- Volunteers
- 170 people
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Ischemic, Intracranial Atherosclerosis
Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study
Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT).
- Conditions
- Stroke, Ischemic, Intracranial Atherosclerosis, Posterior Circulation Brain Infarction
- Trial name
- NCT06453252
- Testing
- we are aiming to develop a Scoring system based on certain variables derived from both groups
- Where
- 2 sites in United States, Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Intracranial Vascular Disorders
Mechanisms of Early Recurrence in Intracranial Atherosclerotic Disease
The objective of this study is to determine the mechanisms of stroke in patients with Intracranial Atherosclerotic Disease (IAD) by specifically evaluating limitations of antegrade flow through the stenotic artery, distal tissue…
- Trial name
- MyRIAD (NCT02121028)
- Where
- 10 sites in United States
- Volunteers
- 105 people
- Sponsor
- University of Miami
High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS
Imaging of Intracranial and Extracranial Arterial Atherosclerotic Plaques Using Different Field Strength MRIs
Atherosclerotic stenosis of the carotid and intracranial arteries is one of the leading causes of ischemic cerebrovascular events worldwide.
- Conditions
- High Resolution Vessel Wall Imaging, Intracranial Atherosclerotic Stenosis, ICAS, Arteriosclerosis
- Trial name
- NCT06754956
- Testing
- The patient will receive two intravenous injections of the same gadoterate meglumine contrast agent.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Intracranial Atherosclerosis
A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this study is to evaluate the safety and effectiveness of CERENOVUS ENTERPRISE 2 intracranial stent implantation in treatment of participants with severe symptomatic intracranial atherosclerotic stenosis.
- Trial name
- NCT05316311
- Testing
- CERENOVUS ENTERPRISE 2 Intracranial Stent
- Where
- 14 sites in China
- Volunteers
- 194 people
- Sponsor
- Medos International SARL
Symptomatic Intracranial Atherosclerotic Stenosis
Drug-Coated Balloon vs Aggressive Medical Management for High-Risk Symptomatic Intracranial Atherosclerotic Stenosis
DR.BEYOND-2 is an investigator-initiated, prospective, multicenter, randomized, open-label, blinded-endpoint, parallel-group clinical trial designed to evaluate the efficacy and safety of drug-coated balloon (DCB) angioplasty…
- Trial name
- DRBEYOND2 (NCT07830277)
- Testing
- Drug-Coated Balloon Angioplasty, Aggressive Medical Management
- Where
- 2 sites in China
- Volunteers
- 570 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Intracranial Atherosclerotic Stroke
Moyamoya Disease Biomarkers in Patients With Intracranial Atherosclerotic Stroke
The aim of this study is to investigate the proportion of patients with moyamoya disease among the patients who were diagnosed as having intracranial atherosclerotic stroke.
- Conditions
- Moyamoya Disease, Intracranial Atherosclerotic Stroke, Intracranial Steno-occlusive Disease
- Trial name
- NCT02074111
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Ischemic Stroke, Intracranial Atherosclerotic Disease
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease
CATIS-ICAD is a clinical pilot study in which patients who have had a recent ischemic stroke, that is a stroke caused by a blood clot or a narrowing of the blood vessels in the brain due to the build up of plaque, will be…
- Trial name
- NCT04142125
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet bid, Acetylsalicyclic acid 81 mg tablet qd
- Where
- 10 sites in Canada
- Volunteers
- 101 people
- Sponsor
- Population Health Research Institute
Stroke, Ischemic, Intracranial Atherosclerosis
Comparison of Cerebral Artery Pressure Gradient and Cerebral Blood Flow Measured by Arterial Spin Labeling
The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS).
- Trial name
- NCT05623943
- Testing
- Endovascular treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Xuanwu Hospital, Beijing
Intracranial Arterial Stenosis, Brain Diseases
Rapamycin-Eluting Vertebral Stents In The Real-World Treatment of Symptomatic Intracranial Atherosclerotic Stenosis
This clinical trial is a prospective, multicenter, single-arm study. About 300 subjects undergoing rapamycin-eluting stent implantation will be enrolled based on the inclusion and exclusion criteria.
- Trial name
- BRIDGE-INTRA (NCT07352852)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Qingdao University
AIS, ICAS - Intracranial Atherosclerosis
A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy
A prospective, multicenter, randomized controlled, open-label, blinded outcome evaluation (PROBE) trial
- Conditions
- AIS, ICAS - Intracranial Atherosclerosis, Stroke
- Trial name
- ICAS LVO-MT (NCT06702657)
- Testing
- balloon dilatation and/or stenting, medication
- Volunteers
- 612 people
- Sponsor
- Changhai Hospital
Atheroscleroses, Coronary, Atheroscleroses, Cerebral
Digital Secondary Prevention After Atherosclerotic Cardiovascular Disease
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality worldwide and in Norway. Approximately 50% of the patients admitted to hospitals with an acute ASCVD event has had a previous…
- Conditions
- Atheroscleroses, Coronary, Atheroscleroses, Cerebral, Atherosclerotic Ischemic Disease
- Trial name
- NCT06738381
- Testing
- Digital intervention and motivational counselling
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Vestre Viken Hospital Trust
Carotid Artery Diseases, Stroke
Boston Scientific Embolic Protection, Inc. (EPI): A Carotid Stenting Trial for High-Risk Surgical Patients (BEACH)
The purpose of this study is to determine whether morbidity and mortality for high-risk surgical patients treated with the Carotid Wallstent in conjunction with the FilterWire EX and EZ System distal protection device will be…
- Conditions
- Carotid Artery Diseases, Stroke, Cerebral Arteriosclerosis
- Trial name
- BEACH (NCT00316108)
- Testing
- WALLSTENT® Endoprosthesis™
- Where
- 50 sites in United States
- Volunteers
- 747 people
- Sponsor
- Boston Scientific Corporation
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Stroke
Effects of Limb Ischemic Postconditioning in Young sICAS
The purpose of this study is to evaluate the protective effects of upper limb ischemic postconditioning on collateral circulationin young symptomatic intracranial atherosclerosis and the baseline characteristics of trial…
- Trial name
- EPIC-sICAS (NCT02323425)
- Testing
- Remote ischemic postconditioning
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xi'an Jiaotong University
Ischemic Stroke
Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS)
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive…
- Trial name
- BAMUS-ICAS (NCT06763458)
- Testing
- Submaximal balloon angioplasty
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region
Intracranial Stenosis, Intracranial Atherosclerotic Disease
Endovascular Recanalization for Symptomatic Chronic Intradural Occlusions
Background: Chronic intracranial large vessel occlusion (LVO), resulting from progressive atherosclerosis or thrombosis, contributes significantly to ischemic strokes, 8-10% in North America and up to 50% in the Chinese…
- Trial name
- Re-CHILL (NCT07072026)
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 80 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracranial Atherosclerosis, Atherosclerotic Plaque
Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)
The primary goal of the trial is to investigate whether the lipid lowering strategy using Alirocumab plus statin could cause more changes from baseline in intracranial atherosclerotic plaque and hemodynamic features during 6…
- Conditions
- Intracranial Atherosclerosis, Atherosclerotic Plaque, Stenosis
- Trial name
- EAST-aICAS (NCT06080256)
- Testing
- Alirocumab, Atorvastatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Atherosclerosis, Cerebral
The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques
Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia.
- Trial name
- INSIST-HRMRI (NCT03753555)
- Testing
- Atorvastatin Calcium, Probucol, PCSK9 inhibitor
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Shenyang Military Region