Clinical trials: Intracranial Haemorrhage
Intracerebral Hemorrhage
Simvastatin For Intracerebral Hemorrhage Study
Study Objective: To analyze if statins are effective in ameliorating perihematomal edema evolution thereby reducing mortality and improving functional outcomes following spontaneous intracerebral hemorrhage (ICH).
- Trial name
- NCT00718328
- Testing
- Simvastatin 80 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Subarachnoid Hemorrhage, Intracranial Hemorrhage
Enteral Nutrition and Glycemic Variability Neurological Intensive Care Unit Study
Primary Objective: To determine the effects of a diabetes specific enteral formula compared to a standard formula supplemented with protein (isocaloric and isonitrogenous) on the mean blood glucose and glycemic variability in a…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhage, Ischemic Strokes, Subdural Hematoma
- Trial name
- ANUS1014 (NCT01463878)
- Testing
- Glycerna, Jevity - Control Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Eastern Virginia Medical School
Chronic Subdural Hematoma
Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma
Chronic subdural hematoma (cSDH) is condition where blood has slowly leaked out of small blood vessels surrounding the brain. Over time, the blood may cause a variety of symptoms including headache, confusion, limb weakness, and…
- Trial name
- DECS (NCT02111785)
- Testing
- Dexamethasone, Burr Hole Craniostomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Acute Ischemic Stroke
Imaging Guided Patient Selection for Interventional Revascularization Therapy
The primary objective of this clinical evaluation is to determine the safety and effectiveness of the Penumbra System in a stroke cohort who presents within 8 hours from symptom and with a known core infarct volume at admission.
- Trial name
- START (NCT00963989)
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Penumbra Inc.
Subarachnoid Hemorrhage
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.
- Trial name
- NCT00795288
- Testing
- Simvastatin, 80 mg/day for 21 days
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Head Trauma, Crushing Skull Injury
Detecting Traumatic Intracranial Hemorrhage With the InfraScanner 2500™ in Uganda
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the portable near-infrared-based device (portable NIR-based device), the InfraScanner 2500™, to detect…
- Conditions
- Head Trauma, Crushing Skull Injury, Head Injury, Head Injuries, Multiple
- Trial name
- NCT06491173
- Testing
- InfraScanner 2500™
- Where
- 2 sites in Uganda
- Volunteers
- 180 people
- Sponsor
- Duke University
Subarachnoid Hemorrhage, Hypertension
Safety and Efficacy Study of Clevidipine to Control Hypertension in Patients Admitted With Aneurysmal Subarachnoid Hemorrhage
This study is designed to assess how rapidly and how safely Clevidipine can be used to control high Blood Pressure in patients with subarachnoid hemorrhage which is a type of brain bleed that happens because of a weak balloon…
- Trial name
- CLASH (NCT00978822)
- Testing
- Clevidipine butyrate injectable emulsion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Henry Ford Health System
Intracerebral Hemorrhage
High-Dose Deferoxamine in Intracerebral Hemorrhage
The main purpose of this study is to determine whether treatment with deferoxamine mesylate is of sufficient promise to improve outcome before pursuing a larger clinical trial to examine its effectiveness as a treatment for brain…
- Trial name
- HI-DEF (NCT01662895)
- Testing
- Deferoxamine, Normal saline
- Where
- 29 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- Beth Israel Deaconess Medical Center
Intracerebral Hemorrhage
The Spot Sign for Predicting and Treating ICH Growth Study
The purpose of this study is to determine if computed tomography angiography can predict which individuals with intracerebral hemorrhage will experience significant growth in the size of the hemorrhage.
- Trial name
- STOP-IT (NCT00810888)
- Testing
- recombinant activated factor VII
- Where
- 10 sites in United States, Canada
- Volunteers
- 92 people
- Sponsor
- University of Cincinnati
Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage
Normoglycemia and Neurological Outcome
Brain injury patients who meet defined criteria will be assigned to intensive insulin treatment (target blood glucose levels of 10-110 mg/dl) or conventional IV insulin treatment (target glucose of 150-170 mg/dl).
- Conditions
- Acute, Non-traumatic Subarachnoid Hemorrhage, Intraparenchymal Hemorrhage, Brain Injuries
- Trial name
- NCT01137773
- Testing
- Insulin, Conventional insulin treatment
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Louisville
Hypertension, Hemorrhage
Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE)
The purpose of this study was to determine the efficacy and safety of clevidipine for treating acute hypertension (high blood pressure, defined as systolic blood pressure >160 mmHg) in patients with intracerebral hemorrhage…
- Trial name
- ACCELERATE (NCT00666328)
- Testing
- clevidipine
- Where
- 17 sites in United States, Germany
- Volunteers
- 37 people
- Sponsor
- The Medicines Company
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Intracerebral Hemorrhage, Stroke, Acute
A Study to Test the SENSE Device in Patients With Intracranial Hemorrhage
The purpose of this research study is to find out whether a device for monitoring bleeding in patients with acute hemorrhagic stroke will show similar findings as CT scans performed to evaluate the stroke.
- Conditions
- Intracerebral Hemorrhage, Stroke, Acute, Stroke Hemorrhagic
- Trial name
- NCT03038087
- Testing
- SENSE Device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sense Diagnostics, LLC
Cerebral Aneurysm, Stroke
Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients
This study aims to determine the inter- and intra-variability of Transcranial Doppler (TCD) ultrasound in neuro-critical care patients who are planned for consecutive daily TCD evaluations.
- Conditions
- Cerebral Aneurysm, Stroke, Vasospasm, Cerebral, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT04583163
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Hackensack Meridian Health
Fever, Brain Hemorrhage
Temperature Control in Central Fever in the Neuro-ICU
There are few treatments for central fever (fever that is due to the central nervous system, as opposed to an infectious source).
- Trial name
- NCT00751634
- Testing
- Gaymar Rapr-Round (external cooling blanket)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Intracerebral Hemorrhage
Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial
The investigators hypothesize that treatment with the iron chelator, Deferoxamine Mesylate, improves the outcome of patients with brain hemorrhage.
- Trial name
- NCT02175225
- Testing
- Deferoxamine Mesylate
- Where
- 28 sites in United States, Canada
- Volunteers
- 294 people
- Sponsor
- Beth Israel Deaconess Medical Center
Intracerebral Hemorrhage
Antihypertensive Treatment of Acute Cerebral Hemorrhage-II
The specific aims of this study are to: 1. Definitively determine the therapeutic benefit of the intensive treatment relative to the standard treatment in the proportion of patients with death and disability (mRS 4-6) at 3 months…
- Trial name
- ATACH-II (NCT01176565)
- Testing
- Intravenous nicardipine hydrochloride
- Where
- 171 sites in United States, Canada and 5 more
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Cerebral Vasospasm
The Intra-arterial Vasospasm Trial
The primary objective of the study is to determine the optimal intra-arterial drug treatment regimen for arterial lumen restoration post cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
- Trial name
- iVAST (NCT01996436)
- Testing
- Nicardipine, Verapamil, Nicardipine + Verapamil + Nitroglycerin
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- Peng Roc Chen, MD