Clinical trials: Intracranial Pathology
Headache, Aneurysm
Headache After Coil Embolization for Unruptured Intracranial Aneurysms
Perform a prospective cohort study to compare the incidence and severity of headache between non-stent assisted coiling and stent assisted coiling of unruptured intracranial aneurysms.
- Conditions
- Headache, Aneurysm, Endovascular Procedures
- Trial name
- NCT03359252
- Testing
- non-stent assisted coiling, stent assisted coiling
- Where
- South Korea
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cerebral Amyloid Angiopathy, Intracranial Hemorrhages
Multimodal Biomarkers for Diagnosis and Prognosis in CAA
By combination of plasma (Aβ40, Aβ42, total tau, and phosphorylated tau, etc.), genetic (ApoE ε2 or ε4 allele), MRI (cerebral perfusion, microbleeds, cortical superficial siderosis, enlarged perivascular space, etc.) and PET…
- Conditions
- Cerebral Amyloid Angiopathy, Intracranial Hemorrhages, Alzheimer Disease
- Trial name
- CAA (NCT03969732)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Aneurysmal Subarachnoid Hemorrhage
Early Brain Damage Assessment in Aneurysmal Subarachnoid Haemorrhage in Predicting Cognitive Impairment
the goal of this type of study : observation study is to learn about cerebral edema and hematoma in aneurysmal subarachnoid hemorrhage the main questions it aims to answer are current clinical practices lack predictive models to…
- Trial name
- NCT06172556
- Testing
- Endovascular coiling, Surgical clipping, Mix
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University
Subarachnoid Hemorrhage
miRNA Profile in Aneurysmal Subarachnoid Haemorrhage
The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.
- Trial name
- miRNA (NCT03344744)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Subdural Hematoma
Randomized Controlled Trial Investigating Optimal Treatment for Chronic Subdural Hematoma
Setup of comparative trial The goal of this study is to determine whether one surgical treatment for chronic subdural hematoma is better than the other.
- Trial name
- NCT02655445
- Testing
- Mini-craniotomy, Twist Drill Craniostomy, Burr Hole Craniostomy
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cerebral Small Vessel Diseases, Cadasil
Taiwan Associated Genetic and Nongenetic Small Vessel Disease
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD…
- Conditions
- Cerebral Small Vessel Diseases, Cadasil, HTRA1-Related Autosomal Dominant Cerebral Angiopathy, COL4A1-Related Brain Small Vessel Disease With Haemorrhage
- Trial name
- TAG-SVD (NCT05473637)
- Testing
- MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Aneurysmal Subarachnoid Hemorrhage
Human Albumin for Clinical Outcome in Aneurysmal Subarachnoid Hemorrhages
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful acute neurological condition with overwhelmingly high rate of associated morbidities and mortality.
- Trial name
- HASH (NCT06548477)
- Testing
- Human albumin
- Where
- Qatar
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Optic Nerve Diameter, Intracranial Pressure Increase
Effect of Optıc Nerve Dıameter ın Tymphanoplasty Surgery Performed ın Lateral Head Posıtıon
Studies exist to determine the effect of laparoscopic surgical procedures on increased intra-abdominal pressure; these studies include optic nerve sheath diameter (ONSD) measurement in various positions such as trendelenburg and…
- Trial name
- ONSD (NCT07407972)
- Testing
- optic nerve diameter
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Acute Ischemic Stroke, Haemorrhagic Stroke
Translational Immunodiagnostics in Stroke (TrImS)
In adult patients presenting to emergency departments within 24 hours of symptom onset with suspected acute stroke, we aim: 1. to identify early brain- and pathology-specific circulating, whole blood, plasma and serum panorOmic…
- Conditions
- Acute Ischemic Stroke, Haemorrhagic Stroke, Transient Ischemic Attacks, Cardioembolic Stroke
- Trial name
- TrImS (NCT05300997)
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Cerebral Microangiopathy, CADASIL
Impact of tDCS on Cerebral Autoregulation
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.
- Conditions
- Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis
- Trial name
- NCT01865604
- Testing
- Anodal tDCS, Cathodal tDCS
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Epilepsy, Migraine
Clinical Applications of High-Frequency Oscillations
The objective of this study is to utilize high-frequency brain signals (HFBS) to localize functional brain areas and characterize HFBS in epilepsy, migraine, and other brain disorders.
- Conditions
- Epilepsy, Migraine, Headache, Pain
- Trial name
- HFOs (NCT00600717)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebral Arterial Diseases
Hemodynamic and Functional Characteristics of the Cerebral Circulation in Obesity
This prospective study is intended to explore differences in the cerebral hemodynamics and vascular functional characteristics between obese and normo-constituted patients; as well as the changes in the hemodynamic and functional…
- Trial name
- HemOB (NCT06067113)
- Testing
- Supraaortic and transcranial duplex
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Cerebral Hemorrhage
Diagnostic Utility of MRI in Intracerebral Hemorrhage
The overall aim of this project is to prospectively determine whether MRI can improve the conventional neuroradiological evaluation (CT with or without cerebral angiography) of patients with a spontaneous ICH or IVH.
- Trial name
- DASH (NCT00363662)
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Analgesia
Opioid Sparing Analgesia: Dexmedetomidine Versus Lidocaine for Intracranial Surgeries in Children
Perioperative pain control is necessary in children as inadequate treatment may lead to progression of perception of pain and development of chronic pain in the future.
- Trial name
- NCT04535089
- Testing
- Dexmedetomidine injection, Lidocaine Iv
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Beta-thalassemia, Glioma
Plasticizer Exposure and Its Consequences on Health
Plasticizers are chemicals commonly found in many everyday items, from food packaging to medical equipment. Although they are pervasive in our daily lives, researchers still don't have a clear picture of their long-term effects…
- Conditions
- Beta-thalassemia, Glioma, Healthy Controls, Transfusion-dependent Beta-Thalassemia
- Trial name
- PEACH (NCT06512298)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna