Clinical trials: Intracranial Pathology
CADASIL
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID).
- Trial name
- NCT05677880
- Testing
- Study Procedures
- Where
- 12 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Cavernous Malformation, Intracerebral Hemorrhage
CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study
The aim of this prospective study is to reveal the natural history of symptomatic hemorrhage in adult patients with cerebral cavernous malformation with the goal of informing the treatment plan.
- Trial name
- CHOCOOATE (NCT02946866)
- Where
- 8 sites in South Korea
- Volunteers
- 228 people
- Sponsor
- Seoul National University Hospital
Stroke, Acute, Intracerebral Hemorrhage
Prospective Cohort of Patients With Intracerebral Hemorrhage
The investigators designed a multicentral, observational, prospective cohort study to provide cortical data for risk stratification and biomarkers on early outcomes, complications, long-term neurological function, and cognitive…
- Trial name
- NCT06670456
- Where
- 6 sites in China
- Volunteers
- 3,000 people
- Sponsor
- De-zhi Kang
Chronic Subdural Hematoma, Chronic Subdural Hematomas
Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma
A chronic subdural hematoma (cSDH) is a type of intracranial hematoma that primarily affects older adults. The rising incidence of this condition, coupled with the high healthcare burden of this disease, calls for an update of…
- Trial name
- ERP-cSDH (NCT07421453)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Subarachnoid Hemorrhage, Traumatic Brain Injury
Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy
Strict glycemic control improves mortality and morbidity of patients admitted to the postoperative intensive care unit (ICU). The investigators would like to know if this therapy could improve the long term neurologic and…
- Conditions
- Subarachnoid Hemorrhage, Traumatic Brain Injury, Intracranial Hemorrhage
- Trial name
- NCT00505505
- Testing
- Insulin (Actrapid)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Roma La Sapienza
Stroke, Intracerebral Hemorrhage
Clinical Outcomes Following Primary Intracerebral Hemorrhage
The investigators design an observational multi-center cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalized…
- Trial name
- COPI (NCT06548737)
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH)
The purpose of the study is to measure how effective and safe three different doses of the drug clazosentan are in preventing vasospasm after subarachnoid hemorrhage.
- Trial name
- CONSCIOUS-1 (NCT00111085)
- Testing
- Clazosentan 1 mg/h, Clazosentan 5 mg/h, Clazosentan 15 mg/h
- Where
- 16 sites in United States, Canada
- Volunteers
- 413 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Subarachnoid Hemorrhage
Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm
The purpose of the study is to examine the safety of a 14 day infusion of sodium nitrite, and to study the pharmacokinetics of nitrite, during a 14 day infusion in patients with ruptured cerebral aneurysms.
- Trial name
- NCT00873015
- Testing
- Sodium nitrite, Saline
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Hope Pharmaceuticals
Blood Pressure, Subarachnoid Hemorrhage
Blood Pressure Treatment in ICU Patients with Subarachniodal Haemorrhage.
An MRI study to examine the relationship between blood pressure and cerebral blood flow in patients with subarachnoidal hemorrhage and suspect or verified vasospasm.
- Conditions
- Blood Pressure, Subarachnoid Hemorrhage, Aneurysm Cerebral
- Trial name
- BFBP (NCT06033378)
- Testing
- Blood pressure elevation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Umeå University
Intracerebral Hemorrhage
Minocycline Accelerates Intracerebral Hemorrhage Absorption
Minocycline has been found to reduce cerebral edema secondary to cerebral hemorrhage, promote hematoma absorption, and shorten hematoma absorption time; clinical studies have been conducted to confirm the safety in the treatment…
- Trial name
- MACHA (NCT05630534)
- Testing
- Minocycline, starch
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Subdural Hematoma
Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients
The proportion of the elderly population is increasing rapidly. Chronic subdural hematoma has become the most common cause of surgery in neurosurgery for elderly patients. The standard treatment for cSDH is mostly surgery.
- Trial name
- CSDH-LP (NCT04607447)
- Testing
- low intracranial pressure strategy treatment, Atorvastatin plus Dexamethasone
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huashan Hospital
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Intracerebral Hemorrhage, Hemorrhagic Stroke
Outcome Prediction and Recovery After Spontaneous Intracerebral Haemorrhage
Spontaneous intracerebral haemorrhage (ICH) is a severe form of stroke with high mortality and frequent long-term disability. Current tools to predict how an individual patient will recover are limited.
- Trial name
- CR-4-Health (NCT07882784)
- Where
- 3 sites in Austria, Slovenia
- Volunteers
- 300 people
- Sponsor
- University Medical Centre Maribor
Dysphagia Following Cerebrovascular Accident
Effect of Home Based Swallowing Exercise in Stroke Patients With Dysphagia
Dysphagia is a common problem in post-stroke patients and greatly impaired quality of life. Among them, the strength of tongue and lip muscles played a key role in the oral phase of swallowing and many stroke survivors suffered…
- Trial name
- NCT05758350
- Testing
- home based IOPI swallow training
- Volunteers
- 100 people
- Sponsor
- Taichung Veterans General Hospital
Intracranial Atherosclerosis
Predicting Stroke Risk in ICAD With Novel MRI
The cerebral and spinal vasculature possesses several unique properties: it is composed of relatively small vessels, it has a highly connected network architecture, and, due to the confined space around the brain, disruptions in…
- Trial name
- NCT05515874
- Testing
- Feraheme
- Where
- United States
- Sponsor
- Northwestern University
Intracerebral Hemorrhage
INTERACT4 Expansion - Validation Study
As an investigator-initiated and conducted, multi-centre, open-label, single-arm prospective observational trial, INTERACT4 Expansion aims to evaluate the feasibility of setting up and conducting a trial that uses a point-of-care…
- Trial name
- INTERACT4 Exp (NCT07231315)
- Testing
- LVOne
- Where
- 6 sites in Australia
- Volunteers
- 163 people
- Sponsor
- The George Institute
Cerebral Hemorrhage
DELP for Acute Hemorrhagic Stroke
Delipid Extracorporeal Lipoprotein filter from Plasma (DELP) has been found to improve neurological function and life ability of AIS patients and approved for the treatment of AIS by China Food and Drug Administration (CFDA).
- Trial name
- NCT04708990
- Testing
- Delipid Extracorporeal Lipoprotein filter from Plasma
- Where
- China
- Volunteers
- 10 people
- Sponsor
- General Hospital of Shenyang Military Region
Intracerebral Hemorrhage, Obstructive Hydrocephalus
A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage
The purpose of this study is to determine if usage of early lumbar drainage leads to less shunt surgery and less catheter associated complications in patients with communicating hydrocephalus after intracerebral hemorrhage with…
- Trial name
- LUCAS-IVH (NCT01041950)
- Testing
- Lumbar drainage
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Intracerebral Hemorrhage, Nontraumatic Intracerebral Hemorrhage
CIRP and Cathepsin B in Neuroinflammation After Intracerebral Hemorrhage
This is a single-center, investigator-initiated, prospective observational case-control study. Patients with intracerebral hemorrhage and healthy controls will be enrolled at Xuanwu Hospital, Capital Medical University.
- Trial name
- CIRP-ICH (NCT07665255)
- Testing
- Blood Sample Collection
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage
A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score
1. The primary aim of this study is to investigate the correlation between the length of ICU stay and a newly developed FIVE score in neuro-intensive care patients. 2.
- Conditions
- Postoperative Intracranial Hematoma, Postoperative Intracranial Haemorrhage, Supratentorial Cancer, Infratentorial Neoplasms
- Trial name
- NCT06036732
- Where
- Turkey (Türkiye)
- Volunteers
- 223 people
- Sponsor
- Istanbul University - Cerrahpasa
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