Clinical trials: Intracranial Pathology
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Aneurysmal Subarachnoid Hemorrhage
Early Lumbar Drainage Plus Intrathecal Urokinase in Severe Aneurysmal Subarachnoid Hemorrhage (LD-ITUK)
The LD-ITUK is a multicenter, prospective, randomized, double-blind, blind endpoint, placebo-control design trial. All eligible patients with the diagnosis of severe aSAH will be randomly assigned to the treatment group or the…
- Trial name
- NCT06284642
- Testing
- Urokinase
- Where
- 25 sites in China
- Volunteers
- 424 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Acute Subdural Hematoma
Scandinavian Multicentre Acute Subdural Hematoma (SMASH) Study
In a multi-national population-based cohort, the investigators want to compare the clinical course and clinical outcome of elderly patients (≥70 y/o) compared with younger patients (< 70 y/o) with acute subdural hematoma treated…
- Trial name
- SMASH (NCT03284190)
- Testing
- Surgery
- Volunteers
- 1,600 people
- Sponsor
- Karolinska University Hospital
Chronic Subdural Hematoma
Tocilizumab (RoActemra) and Tranexamic Acid (Cyklokapron) Used as Adjuncts to Chronic Subdural Hematoma Surgery
Primary objectives of the study are to investigate whether adjuvant treatment in the form of Tranexamic acid (Cyklokapron) and Tocilizumab (RoAcmera) to surgery in patients with chronic subdural hematomaina can: 1.
- Trial name
- NCT03353259
- Testing
- Tranexamic acid and Tocilizumab
- Where
- Norway
- Volunteers
- 382 people
- Sponsor
- Oslo University Hospital
Chronic Subdural Hematoma
Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma
This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma.
- Trial name
- NCT07240454
- Testing
- Aspirin Continuation, Aspirin Discontinuation
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Tao Liu
Marfan Syndrome
Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease
Primary outcome is to compare the frequency and clinical features of spinal symptoms between Marfan patients with dural ectasia (cases) and those without (controls). 1. / Frequency of orthostatic headaches 2.
- Trial name
- MARFANLOMB (NCT05123339)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Intracranial Hemorrhages
Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)
Traumatic Brain Injury (TBI) is a leading cause of death and disability among military personnel, Veterans, and civilians. One of the most dangerous complications of moderate-to-severe TBI is intracranial hemorrhage (ICH).
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Combat Casualty Care, Point of Care
- Trial name
- NIRD-HI (NCT07338383)
- Testing
- NIRD-HI scan at the time of enrollment, Secondary NIRD-HI scan when a planned repeat CT is performed
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
CADASIL
The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage?
The Cerebral Amyloid angiopathy (CAA) is the leading cause of cortical hemorrhage after 65 years. The presence of cerebral infarction is also reported anatomically in the AAC. MRI studies of these infarcts are rare.
- Trial name
- CAA (NCT02837354)
- Testing
- No intervention
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Intracranial Hemorrhages
Efficacy of Acupuncture in Patients With Acute Intracranial Hemorrhage
Investigators propose a research design protocol to evaluate the efficacy of acupuncture in improving function recovery after acute intracranial hemorrhage.
- Trial name
- NCT06243237
- Testing
- Acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Infarction, Middle Cerebral Artery, Ischemic Stroke,
Implantation of Olfactory Ensheathing Cells (OECs)
Recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. The Olfactory Ensheathing Cells (OECs) will be cultured and expanded under the rule of GTP.
- Conditions
- Infarction, Middle Cerebral Artery, Ischemic Stroke,, Stroke With Hemiparesis,, Thromboembolic Stroke.
- Trial name
- OECs (NCT01327768)
- Testing
- Olfactory ensheathing cells
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Spontaneous Subarachnoid Hemorrhage
Time to Specialized Admission in Case of Severe Brain Haemorrhage.
Spontaneous subarachnoid haemorrhages (SAH) are a particularly severe type of stroke with a tendency to affect younger individuals than other types of stroke.
- Trial name
- NCT03786068
- Where
- Denmark
- Volunteers
- 262 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Cadasil
CERebrolysin In CADASIL
The objective of this trial is the global risk-benefit assessment of Cerebrolysin as compared to Placebo in patients with genetically proven CADASIL.
- Trial name
- CERICA (NCT05755997)
- Testing
- Cerebrolysin, 0.9 % NaCl
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Ever Neuro Pharma GmbH
Chronic Subdural Hematoma
Swedish Trial on Embolization of Middle Meningeal Artery Versus Surgical Evacuation in Chronic Subdural Hematoma
The SWEMMA trial is an open, national, multi-center, prospective, randomized (1:1), superiority trial designed to assess impact on reoperation rates for chronic subdural hematoma with a head-to-head comparison of embolization of…
- Trial name
- SWEMMA (NCT05267184)
- Testing
- Endovascular treatment of the middle meningeal artery, Standard neurosurgical hematoma evacuation
- Where
- 4 sites in Sweden
- Volunteers
- 288 people
- Sponsor
- Region Skane
Memory Impairment, Dementia, Vascular
CognivAiD Real-World Evidence Clinical Registry (CONNECT Registry)
This is an observational, prospective cohort of patients who were prescribed or have taken CognivAiD as prescribed by the attending physician. The safety and efficacy of CognivAiD have been established in clinical studies.
- Trial name
- CONNECT (NCT06228638)
- Testing
- CognivAID (Sailuotong)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Moleac Pte Ltd.
Stroke
Long Term Outcome After Hemorrhagic Stroke Surgery
The investigators retrospectively reviewed all patients with neurosurgical operations for hemorrhagic stroke (intracerebral hemorrhage) between 1999 and 2008.
- Trial name
- NCT01409252
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Intracranial Hemorrhages, Head Trauma
PREhospital Prediction of the Risk of Intracranial Hemorrhagic Injury in the Elderly Patient With a Fall
Monocentric study at Toulouse University Hospital. A questionnaire collecting the elements of the study is made available to regulating physicians.
- Trial name
- PRELHIC (NCT06784284)
- Testing
- Glasgow Outcome Scale -Extended (GOSE)
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Toulouse
Dementia, Alzheimer Disease
Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial
This is an extension trial of a prior trial (NCT02213458). Both persons with dementia (PWD) and their caregivers were enrolled as dyads.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT04287738
- Testing
- Navigated Care
- Volunteers
- 912 people
- Sponsor
- University of California, San Francisco
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
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