Clinical trials: Intracranial Pressure Increase
Idiopathic Intracranial Hypertension
MR Lymphatic Imaging in Idiopathic Intracranial Hypertention
In the brain and its borders, blood vessels coexist with lymphatic vessels exclusively in the dura mater, the outermost layer of meninges.
- Trial name
- LYMPHIMAGIIH (NCT05762367)
- Testing
- 3T MRI with Gadobutrol injection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intracranial Pressure Increase, Postoperative Cognitive Dysfunction
The Effect of Optic Nerve Diameter on Postoperative Cognitive Function in Laparoscopic Hysterectomy
Prospective study, 40 patients ASA 2-3, 30-75 years old who were planned for laparoscopic hysterectomy operation will be included.One day before the operation and postoperative 1.3.7.
- Trial name
- NCT05286697
- Testing
- measuring optic nerve diameter
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Stroke, Diabetic Ketoacidosis
Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients
This study involves looking at Cerebral oximetry measurements in pediatric and neonatal patients who are experiencing a critical illness. Such as Altered mental status, seizures, trauma, sepsis, etc.
- Conditions
- Stroke, Diabetic Ketoacidosis, Increased Intracranial Pressures, Altered Mental Status
- Trial name
- NIRSCI (NCT02950181)
- Testing
- NIRS
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Intracranial Hypertension
Clinical Value of Noninvasive Intracranial Pressure Measurement
The aim of the study is to evaluate accuracy and precision of non-invasive intracranial pressure measurement device (Vittamed 205) for selected patients compared with cerebrospinal fluid pressure measured during lumbar puncture
- Trial name
- Braincare (NCT02130219)
- Testing
- Non-invasive intracranial pressure measurement, Brain MRI/CT, Lumbar puncture and cerebrospinal fluid pressure measurement
- Where
- Lithuania
- Volunteers
- 45 people
- Sponsor
- Lithuanian University of Health Sciences
Traumatic Brain Injury
Measurement of Optic Nerve Sheath in Traumatic Raised Intracranial Pressure
Trauma patients are at risk for serious head trauma. The consequences of serious head trauma are often life altering. Currently, the only method available to rapidly assess the severity of head injury and need for neurosurgical…
- Trial name
- MOONSTRIP (NCT00783809)
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- McMaster University
Idiopathic Intracranial Hypertension (IIH)
Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early Phase
This study is aimed at patients suffering from recently discovered intracranial hypertension, caracterized by visual loss, chronic headache and/or tinnitus.
- Trial name
- DIVE IIN EARLY (NCT06919744)
- Testing
- Best medical care, Intervention (stenting)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- University Hospital, Montpellier
Idiopathic Intracranial Hypertension
Ocular Perfusion in Patients With Idiopathic Intracranial Hypertension
The proposed study aims to evaluate optic nerve head blood flow and microcirculation in patients with idiopathic intracranial hypertension.
- Trial name
- NCT06545981
- Testing
- Lumbar puncture and administration of medication
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems
Acute Liver Failure, Hepatic Encephalopathy
The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
The main objective of this study is to investigate the effect of Prometheus liver support dialysis on intracranial pressure, cerebral metabolism and circulation in patients with acute liver failure.
- Conditions
- Acute Liver Failure, Hepatic Encephalopathy, Intracranial Hypertension
- Trial name
- NCT00655304
- Testing
- Prometheus (R) liver support dialysis, CVVHDF (Continuously Veno-Venous Hemodiafiltration)
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Liver Failure
Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF
Patients with ALF (Acute liver Failure) would undergo a detailed clinical evaluation. Information would be collected regarding the onset and duration of symptoms, etiology, and severity of disease, other baseline clinical…
- Trial name
- NCT02460510
- Testing
- Mannitol, 3% hypertonic saline
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Idiopathic Intracranial Hypertension
Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.
Assessing the safety and effectiveness of a 11-βhydroxysteroid dehydrogenase type 1 inhibitor (AZD4017), in a placebo controlled trial, in acute idiopathic intracranial hypertension (IIH) IIH is a condition of young, overweight…
- Trial name
- IIH:DT (NCT02017444)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Liver Transplantation
Incidence of Intracranial Hypertension During Liver Transplantation Estimated by Non-invasive Ultrasound Methods.
Acute or chronic liver failure (fulminant hepatitis or advanced cirrhosis) disrupts brain physiology. Beyond classical hepatic encephalopathy, intracranial hypertension may occur.During liver transplantation (LT) surgery, many…
- Trial name
- TOH-HTIC (NCT02695823)
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Benign Intracranial Hypertension
Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, primarily affecting overweight females of childbearing age.
- Trial name
- NCT04032379
- Testing
- Standard treatment
- Where
- 2 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Headache Center
Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase
Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound
The aim of this study is to evaluate the effects of different carbon dioxide gas insufflation pressures on the ultrasound-guided optic nerve sheath diameter in patients undergoing laparoscopic cholecystectomy and to determine the…
- Conditions
- Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase, Laparoscopic Cholecystectomy Surgery
- Trial name
- ONSD ETD (NCT07784361)
- Testing
- Low Pressure Group, High Pressure Group
- Volunteers
- 68 people
- Sponsor
- Gaziantep City Hospital
Intracranial Hypertension
Assessment of Venous Drainage in Idiopathic Intracranial Hypertension
Intracranial hypertension (IIH) is a disorder producing a syndrome of increased intracranial pressure secondary to a compressive intracranial lesion or said to be idiopathic.
- Trial name
- HYPERPIC (NCT04115553)
- Testing
- MRI examination, ECG
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Severe Traumatic Brain Injury, Intracranial Hypertension
Ketamine for Sedation in Severe Traumatic Brain Injury
This protocol is for an open-label randomized trial evaluating the safety of using ketamine in combination with propofol for sedation versus the standard of care analgosedation in patients admitted to the intensive care unit with…
- Conditions
- Severe Traumatic Brain Injury, Intracranial Hypertension, Intracranial Hemorrhage, Hypertensive
- Trial name
- Ketamine (NCT06429657)
- Testing
- Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus
Studies in patients with intracranial hypertension have shown a good relationship between optic nerve sheath diameter measured by retrobulbar ultrasound and invasively measured intracranial pressure.
- Trial name
- NCT01863329
- Testing
- retrobulbar ultrasound
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Intracranial Hypertension
Optic Nerve Sheath Diameter in Low-flow and Normal-flow Rate Anesthesia
Laparoscopic cholecystectomy is one of the regularly performed laparoscopic surgical procedures. It resulted in shorter hospital stays, improved cosmetic outcomes, and reduced bleeding and pain.
- Trial name
- NCT05946200
- Testing
- Low flow technique in general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya City Hospital