Clinical trials: Intracranial Surgery
Cerebral Aneurysm Unruptured, Iron Deficiency Anemia
Effect of Preoperative Intravenous Ferric Carboxymaltose for Clipping Surgery
Hypothesis: Correction of preoperative anemia can reduce the need for intra-/postoperative RBC transfusions and can improve surgical outcomes.
- Conditions
- Cerebral Aneurysm Unruptured, Iron Deficiency Anemia, Surgery
- Trial name
- PICASA (NCT04616092)
- Testing
- FEFINJECT
- Volunteers
- 130 people
- Sponsor
- Seoul National University Hospital
Hematoma, Subdural, Chronic
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma
Rationale: Chronic subdural hematoma (cSDH) is a frequently occurring disease, occurring mainly in the elderly. Surgical evacuation is effective, but also associated with life-threatening risks.
- Trial name
- TORCH (NCT03582293)
- Testing
- Tranexamic Acid 500Mg Tablet
- Where
- Netherlands
- Volunteers
- 554 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intracerebral Hemorrhage, Minimally Invasive Surgical Procedures
Dutch Intracerebral Hemorrhage Surgery Trial
Background: Intracerebral hemorrhage (ICH) accounts for 16-19% of all strokes in Western Europe and contributes profoundly to mortality and disability.
- Conditions
- Intracerebral Hemorrhage, Minimally Invasive Surgical Procedures, Endoscopic Surgical Procedures
- Trial name
- DIST (NCT05460793)
- Testing
- Minimally invasive endoscopy-guided surgery
- Where
- 11 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Total Knee Replacement, Optic Nerve Sheath Diameter Measurement
The Effect of Epidural Anesthesia on Optic Nerve Sheath Diameter Measurements in Total Knee Prosthesis Surgery
This study investigates the effects of epidural anesthesia on intracranial pressure (ICP) by using ultrasonographic optic nerve sheath diameter (ONSD) measurements as a non-invasive indicator.
- Conditions
- Total Knee Replacement, Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Change
- Trial name
- NCT07458321
- Testing
- Bupivacaine %0.25 (isobaric), Bupivacaine %0.5 (hyperbaric)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Moyamoya Disease
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD).
- Trial name
- BLOSSOM (NCT06634004)
- Testing
- BOLD MRI
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Stroke
Long Term Outcome After Hemorrhagic Stroke Surgery
The investigators retrospectively reviewed all patients with neurosurgical operations for hemorrhagic stroke (intracerebral hemorrhage) between 1999 and 2008.
- Trial name
- NCT01409252
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Idiopathic Intracranial Hypertension
An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH
Idiopathic intracranial hypertension (IIH) is a condition with an unknown cause or causes. The condition is associated with raised pressure in the brain and can cause disabling daily headaches and loss of sight, which can be…
- Trial name
- IIH:WT (NCT02124486)
- Testing
- Bariatric surgery, Dietetic intervention
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Intracranial Hypertension, Brain Edema
Optical Nerve Sheath Changes During Head Down Laparoscopy
Patient undergoing laparoscopic radical prostatectomy in steep trendelenburg position are at risk to develop complication from brain edema.
- Conditions
- Intracranial Hypertension, Brain Edema, Pneumoperitoneum, Surgery, Laparoscopic
- Trial name
- NCT03957837
- Testing
- Optical nerve sheath diameter ultrasound measurement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Stroke, Coronary Artery Disease
Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
There are many reports about the association of coronary artery disease (CAD) and cerebral artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the revascularization including coronary bypass…
- Conditions
- Stroke, Coronary Artery Disease, Arrhythmia
- Trial name
- NCT00247533
- Testing
- Digital subtraction angiography and 24-hour simultaneous recorder of electrocardiograph
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Brain Tumor Adult, Awake Surgery
Assessment of Tiredness During Awake Resection of Intracerebral Tumors
Occasional patients with intracranial tumors need to have a planned awakening during surgery to avoid major disability from the tumor resection. During the awake part of the surgery an increasing degree of tiredness is observed.
- Trial name
- NCT06922487
- Testing
- Karolinska Sleepiness Scale, KSS
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Region Skane
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Intraoperative Hypotension
Effects of Remimazolam on the Intraoperative Hemodynamics in Bypass Surgery
This study is a randomized, controlled trial. A total of 72 patients will be randomized to receive remimazolam anesthesia or balanced anesthesia (propofol + desflurane) during extracranial-intracranial bypass surgery.
- Trial name
- NCT05557253
- Testing
- Remimazolam, Balanced Anesthesia
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Thrombelastography, Liver Transplant
Personalized ViscoElastic Testing-guided Bleeding Management In Liver Surgery, Neurosurgery and Obstetrics
The ClotPro analyzer is a new generation viscoelastic analyzer for the in vitro assessment of blood coagulation. This study aims to assess the agreement of ClotPro 6.0, ROTEM delta, and TEG 6s in three distinct cohorts: i)…
- Conditions
- Thrombelastography, Liver Transplant, Postpartum Hemorrhage, Bleeding Disorder
- Trial name
- VETILNO (NCT06635564)
- Testing
- Viscoelastic testing
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Intracerebral Hemorrhage (ICH)
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage
The aim of this pilot study is to provide an assessment of safety and feasibility of early minimally invasive image guided endoscopic hematoma evacuation (within 24 hours of symptom onset) in patients suffering from intracerebral…
- Trial name
- NCT04805177
- Testing
- hematoma evacuation
- Where
- 2 sites in Switzerland
- Volunteers
- 11 people
- Sponsor
- University Hospital, Basel, Switzerland
Aortic Valve Stenosis, Extracorporeal Circulation
Cerebral Embolic Load in Patients Undergoing Surgical Aortic Valve Replacement: A Comparison of the Conventional With the Minimized Extracorporeal Circulation Technique Using Transcranial Doppler Ultrasound
In this study, the investigators aim to compare cerebral embolic load in patients undergoing surgical aortic valve replacement using either the minimized extracorporeal circulation or the conventional extracorporeal circulation…
- Trial name
- AKE-MECC (NCT02308566)
- Testing
- Minimized Extracorporeal Circulation (MECC), Conventional Extracorporeal Circulation (CECC)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intracranial Aneurysm
Surgical Management of Complex Intracranial Aneurysms With Hybrid Operating Techniques
To evaluate the clinical benefits and risks of hybrid operating techniques in management of complex intracranial aneurysms, which could coexists with multiple risk factors.
- Trial name
- CIA-HOTs (NCT03206853)
- Testing
- Hybrid Operating Techniques
- Where
- China
- Volunteers
- 258 people
- Sponsor
- liuxingju
Intracranial Surgery
Investigation of the Effects of Discharge Education Strategies on Quality of Life and Daily Living Activities in Patients Who Have Undergone Intracranial Surgery.
It was planned to provide education using verbal education or verbal and picture-text brochure method as a discharge education strategy for patients who underwent intracranial surgery.
- Trial name
- NCT07012681
- Testing
- discharge training (oral and written brochure), discharge education (oral education)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bahçeşehir University
Epilepsy
The Influence of SISCOM on Intracranial Electrode Implantation in Epilepsy Surgical Candidates
The aim of this study is to determine the role of SISCOM (see below) in aiding clinicians to manage epilepsy surgery candidates. SISCOM is already a routine component of pre-surgical epilepsy evaluation at Mayo Clinic.
- Trial name
- NCT00587951
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Intracranial Hemorrhage Ruptured Aneurysm
International Subarachnoid Aneurysm Trial II
The purpose of this study is to compare the clinical outcome of surgical clipping and endovascular coiling for ruptured intracranial aneurysms not included in the original ISAT Study.
- Trial name
- ISATII (NCT01668563)
- Testing
- surgical management, Endovascular management
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 1,724 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial
Covers to Improve Esthetic Outcome After Surgery for Chronic Subdural Hematoma
The clinical-functional result after frontal and parietal burr-hole trepanation for the treatment of chronic subdural hematoma (cSDH) is effective with regards to control of the hematoma and regression of symptoms (headache…
- Conditions
- Hematoma, Subdural, Chronic, Hematoma, Subdural, Intracranial, Haematoma;Subdural;Traumatic
- Trial name
- CORRECT-SCAR (NCT03755349)
- Testing
- Placement of burr-hole covers, No placement of burr-hole covers
- Where
- Switzerland
- Volunteers
- 83 people
- Sponsor
- University of Zurich