Clinical trials: Intractable Cancer
Intractable Pain, Palliative Care
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like plant.
- Trial name
- NCT00804154
- Testing
- Intrathecal Resiniferatoxin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Intractable Pain, Palliative Care
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
Background: Cancer-induced bone pain (CIBP) is common in people with cancer. Bone cancer can also lead to anxiety, depression, and reduced mobility and quality of life.
- Trial name
- NCT02522611
- Testing
- Resiniferatoxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cancer Pain, Refractory Pain
Radiosurgery for Severe Refractory Cancer Pain: A Sham-Controlled Pilot Trial
This pilot randomized trial assessed whether a sham-controlled comparison of triple-target stereotactic radiosurgery is feasible in adults with advanced (stage IV) cancer and severe mixed pain refractory to optimized…
- Trial name
- NCT07871123
- Testing
- Triple-target stereotactic radiosurgery
- Where
- El Salvador
- Volunteers
- 10 people
- Sponsor
- Centro Internacional del Cáncer
Malignant Bowel Obstruction, Cancer Pain
Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction
Malignant bowel obstruction is a frequent complication of advanced cancer, particularly of abdominal and pelvic origin, and most affected patients experience pain.
- Conditions
- Malignant Bowel Obstruction, Cancer Pain, Intestinal Obstruction
- Trial name
- NCT07856251
- Testing
- Lidocaine
- Volunteers
- 50 people
- Sponsor
- Fundación Santa Fe de Bogota
Cancer Pain, Intractable Pain
MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain Patients
This observational study aims to evaluate changes in the spinal cord following CT-guided percutaneous cervical cordotomy performed for the treatment of intractable cancer-related pain.
- Conditions
- Cancer Pain, Intractable Pain, Spinal Cord Edema, Neuropathic Pain
- Trial name
- CORD-MRI (NCT07400055)
- Testing
- CT-guided Percutaneous Cervical Cordotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Mersin University
Leukemia, Aplastic Anemia
Methadone as an Alternative Treatment for Children Underdoing HSCT
Mucositis is a normal side effect of stem cell transplant which happens as a result of chemotherapy being given prior to a new donor cell infusion (bone marrow transplant).
- Conditions
- Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes, SCID
- Trial name
- MATCH (NCT06940570)
- Testing
- PCA plus methadone (Experimental), PCA Alone (SOC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Advanced Cancer, Intractable Pain
Intrathecal Morphine Administration Using Implantable Pump With Continuous or Programmable Flow
The aim of this study is to compare intrathecal morphine administration: using a pump with continuous or programmable flow.
- Trial name
- PITAC (NCT01567345)
- Testing
- Implantable pump with continuous flow, Implantable pump with programmable flow.
- Where
- 6 sites in France
- Volunteers
- 54 people
- Sponsor
- Institut Cancerologie de l'Ouest
Pain, Intractable, Pain Cancer
Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced Cancer
This Phase 2 study assesses the safety and efficacy of a single injection of Resiniferatoxin versus placebo for the treatment of intractable advanced cancer pain.
- Conditions
- Pain, Intractable, Pain Cancer, Pain
- Trial name
- NCT05067257
- Testing
- Resiniferatoxin
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Sorrento Therapeutics, Inc.
Chronic Pain, Cancer Pain
Prometra Post-Approval Study
The Prometra Pump is approved by the FDA for use in the United States. The purpose of this study is to collect long-term safety data on the Prometra Pump.
- Conditions
- Chronic Pain, Cancer Pain, Intractable Pain, Back Pain
- Trial name
- NCT01854229
- Testing
- Prometra Programmable Intrathecal Infusion Pump
- Where
- 26 sites in United States
- Volunteers
- 400 people
- Sponsor
- Flowonix Medical
Cancer Pain, Refractory Pain
Transcranial Direct-current Stimulation (tDCS) Efficacy in Refractory Cancer Pain.
Pain is a common symptom in palliative care cancer patients and is often insufficiently relieved. The 2010 INCA report showed that France is not an exception to this worldwide observation (synopsis of the 2010 national survey).
- Trial name
- STIMPAL (NCT04683172)
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Elsan
Intractable Epilepsy, Malignant Glioma
Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy
This phase IV trial studies the side effects and how well perampanel works in reducing seizure frequency in patients with high-grade glioma and focal epilepsy. Perampanel is a drug used to treat seizures.
- Conditions
- Intractable Epilepsy, Malignant Glioma, Seizure Disorder, WHO Grade 2 Glioma
- Trial name
- NCT04650204
- Testing
- Anticonvulsant Agent, Perampanel, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Pain, Neuropathic Pain
Safety and Activity Study of Intrathecally Administered Ziconotide for Neuropathic Pain in Patients With Cancer
Neuropathic pain is difficult to control because it is only partially sensitive to opioid analgesics, and requires the addition of other therapies such as antidepressants and epileptics.
- Conditions
- Pain, Neuropathic Pain, Intractable Pain, Cancer
- Trial name
- ZIDON (NCT00996983)
- Testing
- ziconotide
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute, Naples
Advanced Cancer
Observational Study of Incidence of Breakthrough Cancer Pain and How it is Treated
The purpose of this study is to describe how often advanced cancer patients experience breakthrough pain (BTcP), and to describe how this pain is treated, and how effective these treatments are.
- Trial name
- Break-1 (NCT02069067)
- Where
- 3 sites in Italy
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute, Naples
Pain, Intractable, Pain Cancer
Phase 3 Study to Assess Resiniferatoxin vs Standard of Care for the Treatment of Intractable Cancer Pain
This is a Phase 3 study to assess the safety and efficacy of a single epidural administration of Resiniferatoxin versus standard of care for the treatment of intractable pain associated with cancer.
- Trial name
- NCT04572776
- Testing
- Resiniferatoxin, Standard of Care
- Sponsor
- Sorrento Therapeutics, Inc.
Cancer Pains
Change the Dose Frequency of Controlled-Release Oxycodone to Refractory Pain
Many patients with cancer experience moderate to severe pain that requires treatment with strong opioids, of which oxycodone and morphine are examples, they are widely applied in clinical treatment because of sustained-released…
- Trial name
- NCT03639415
- Testing
- Increasing the Controlled-Release Oxycodone dose frequency
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fujian Cancer Hospital
Bone Neoplasms, Pain, Intractable
A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer
The purpose of this study is to assess the analgesic efficacy of flexibly-dosed pregabalin in the adjunctive treatment of subjects with cancer-induced bone pain.
- Conditions
- Bone Neoplasms, Pain, Intractable, Cancer
- Trial name
- COPE (NCT00381095)
- Testing
- Pregabalin
- Where
- 55 sites in United States, Canada and 17 more
- Volunteers
- 152 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Arsenic Trioxide, p53 Mutations
Arsenic Trioxide for Structural p53 Mutations
TP53 is the most frequently mutated gene in cancer, but these mutations remain therapeutically non-actionable. Previous study reported arsenic trioxide could rescue structural p53 mutations, endowing p53 mutations with…
- Conditions
- Arsenic Trioxide, p53 Mutations, Refractory Cancer, Intractable Cancer
- Trial name
- NCT04695223
- Testing
- Arsenic Trioxide
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Changzheng Hospital
Intractable Cancer Pain
Study to Evaluate Safety and MTD of Epidural Resiniferatoxin Injection for Treatment of Intractable Cancer Pain
The study is a multicenter, open-label Phase 1b single dose escalation safety study for adult subjects with intractable pain associated with cancer in any area below the mid-thoracic level who meet all other eligibility criteria.
- Trial name
- NCT03226574
- Testing
- Resiniferatoxin
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Sorrento Therapeutics, Inc.
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Intractable Pelvic Cancer Pain
Fluoroscopic &Ultrasonographic Guidance of Superior Hypogastric Plexus Neurolysis in Intractable Pelvic Pain
fluoroscopic group \& includes 30 patients where SHPB will be done Fluoroscopic-guided (the posterior oblique trajectory technique.the double modality group \& includes 30 patients where SHPB will be done using our described new…
- Trial name
- NCT03606811
- Testing
- fluroscopic guided block, double modality (ultrasound and fluroscopic) guided block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University