Clinical trials: Intractable Pain
Angina, Unstable, Angioplasty, Transluminal, Percutaneous Coronary
A Study Evaluating the Efficacy and Safety of Abciximab, an Anti-Platelet Therapy, in Patients With Unstable Angina Not Responding to Standard Medical Therapy Who Are Eligible for Coronary Angioplasty
The purpose of this study is to evaluate the safety and efficacy of abciximab, an anti-platelet therapy, versus placebo in patients with unstable angina who are not responding to standard medical therapy and who are eligible for…
- Trial name
- NCT00269906
- Testing
- Abciximab
- Volunteers
- 1,265 people
- Sponsor
- Centocor, Inc.
Ketamine, Refractory Cancer Pain
Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients
To establish the role of ketamine in hospitalized terminally ill cancer patients with refractory cancer pain, using continuous intravenous infusion of ketamine
- Trial name
- CIVIK (NCT03362073)
- Testing
- Ketamine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Pusan National University Yangsan Hospital
Pain, Amputation
Sciatic Block in Contralateral Limb Phantom and Residual Limb Pain
Participants with chronic, refractory phantom limb pain (PLP) or residual limb pain (RLP) for more than 6 months will be enrolled in this clinical trial.
- Trial name
- NCT05046639
- Testing
- 10 mL 2% lidocaine, 10 mL preservative free saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Chronic Intractable Pain
The True Efficacy of Burst Spinal Cord Stimulation in the Management of Intractable Low Back Pain (TRU-BURST)
The purpose of this prospective, multi-center, randomized, triple-blind, sham-controlled study with parallel economic evaluation is to test the analgesic superiority of BurstDR-SCS compared to sham stimulation using both…
- Trial name
- NCT06030284
- Testing
- BurstDR-SCS
- Where
- 5 sites in Canada, United Kingdom
- Sponsor
- Abbott Medical Devices
Primary Dysmenorrhea
Efficacy of Transcranial Direct Current Stimulation for Severe Primary Dysmenorrhea
Primary Dysmenorrhea (PDM), defined as menstrual pain without discernable organic causes, is inexorably common in adolescent women, about 40-90% of women may suffer from it, and 20% of them can be severe in the context of being…
- Trial name
- NCT03594916
- Testing
- Active tDCS
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Erythromelalgia
Spinal Cord Stimulation for Refractory Pain in Erythromelalgia
Erythromelalgia is a rare disorder characterized by red, warm, and painful extremities, which is often precipitated by warm conditions. The pathophysiology is incompletely understood.
- Trial name
- NCT04039633
- Testing
- Burst Spinal Cord Stimulation
- Where
- 4 sites in Norway
- Volunteers
- 6 people
- Sponsor
- St. Olavs Hospital
Refractory Angina Pectoris, Refractory Angina
Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina
REGENERATE-COBRA will examine whether autologous stem cell treatment can improve angina symptoms and quality of life for patients with refractory angina.
- Trial name
- RegenCobra (NCT05711849)
- Testing
- Bone marrow aspiration and a single intracoronary infusion of autologous bone marrow-derived mononuclear cells.
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Barts & The London NHS Trust
Complex Regional Pain Syndrome
Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02094352
- Testing
- Ketamine Infusion + Epidural Infusion, Control Group + Epidural infusion, Ketamine Booster Infusion
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Metastatic Cancer, Prostate Cancer
Strontium Compared With Radiation Therapy in Treating Patients With Hormone-Refractory Prostate Cancer With Painful Bone Metastases
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for prostate cancer.
- Trial name
- NCT00002503
- Testing
- strontium chloride Sr 89
- Where
- 21 sites in Belgium, Denmark and 7 more
- Volunteers
- 204 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Failed Back Surgery Syndrome
Value of Target-controlled Intravenous Anaesthesia (TCIVA) in Spinal Cord Stimulation
Study design 60 patients Monocenter prospective study Randomized in 2 groups 36 months Objectives Demonstrate the superiority of target controlled intravenous anesthesia versus total anesthesia with the low back paresthesia…
- Trial name
- AIVOC (NCT02821897)
- Testing
- Target-controlled intravenous anaesthesia, Total anaesthesia
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Poitiers University Hospital
Angina, Stable
Ad5FGF-4 In Patients With Refractory Angina Due to Myocardial Ischemia
The purpose of this study is to determine whether a single intracoronary infusion of an adenovirus serotype 5 virus expressing the gene for human fibroblast growth factor-4 (Ad5FGF-4) is effective in improving angina-limited…
- Trial name
- AFFIRM (NCT02928094)
- Testing
- Ad5FGF-4
- Volunteers
- 160 people
- Sponsor
- Angionetics Inc.
Pain, Intractable, Pain Cancer
Study to Assess Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated With Advanced Cancer
This Phase 2 study assesses the safety and efficacy of a single injection of Resiniferatoxin versus placebo for the treatment of intractable advanced cancer pain.
- Conditions
- Pain, Intractable, Pain Cancer, Pain
- Trial name
- NCT05067257
- Testing
- Resiniferatoxin
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Sorrento Therapeutics, Inc.
Pain, Cervical, Discogenic Pain
Evaluation of Efficacy and Safety of Intradiscal Gelified Ethanol in Refractory Cervical Discogenic Pain
The purpose of this study is to assesse safety and efficacy of the Intradiscal Gelified Ethanol for treatment in refractory cervical discogenic pain.
- Trial name
- DISCOCERV (NCT05969392)
- Testing
- Intradiscal Gelified Ethanol (Discogel)
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Gelscom SAS
Overactive Bladder
Is 10 Injections of Bladder Botox Less Painful Than 20 Injections?
The purpose of this research study is to help determine if 10 injections of Botox ® 100 units is less painful than 20 injections of Botox ® 100 units based on effectiveness in reducing urge incontinence episodes.
- Trial name
- NCT04124939
- Testing
- OnabotulinumtoxinA 100 Units
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Refractory Pain, Metastatic Cancer
Dexmedetomidine Addition to Morphine in Patients With Metastatic Cancer
Pain is a common symptom in patients nearing the end of life. Its prevalence varies between 30 and 75%. Nowadays, morphine is the most used molecule as first line treatment of moderate to severe pain.
- Trial name
- NCT03936205
- Testing
- Dexmedetomidine
- Volunteers
- 18 people
- Sponsor
- Hotel Dieu de France Hospital
Sacroiliac Joint Pain
Peripheral Nerve Stimulation for Treatment of Sacroiliac Joint Pain
Prospective randomized controlled study, primary objective: Pain reduction in patients with chronic Sacroiliac joint pain after therapy either with Peripheral Nerve Stimulation or with best medical treatment.
- Trial name
- SIlencing (NCT05357300)
- Testing
- Peripheral Nerve Stimulation
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- PD Dr. med. Simon Bayerl
Pain, Intractable
Phase III Clinical Trial of Fentanyl Transdermal Matrix Patch, in the Management of Chronic Intractable Pain- Assessment of Effectiveness, Safety and Pharmacokinetics
The purpose of this study is to verify the effectiveness, and safety in Japanese patients with chronic intractable pain after 4-week medication of fentanyl transdermal matrix patches containing either 12.5 mcg/hr, 25 mcg/hr, 50…
- Trial name
- NCT00216684
- Testing
- fentanyl
- Volunteers
- 139 people
- Sponsor
- Janssen Pharmaceutical K.K.
Angina Pectoris, Angina Pectoris, Stable
REDUCER-I: An Observational Study of the Neovasc Reducer™ System
The purpose of this study is to collect long term data of the Reducer System in subjects with refractory angina pectoris.
- Conditions
- Angina Pectoris, Angina Pectoris, Stable, Chronic Stable Angina
- Trial name
- NCT02710435
- Testing
- Reducer System
- Where
- 25 sites in Austria, Belgium and 7 more
- Volunteers
- 400 people
- Sponsor
- Shockwave Medical, Inc.
Migraine, Aura
MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant
The objective of the study is to investigate the safety and effectiveness of PFO closure with the BioSTAR Septal Repair Implant System in a population of patients that have refractory migraine (with aura) and who have failed…
- Conditions
- Migraine, Aura, Patent Foramen Ovale
- Trial name
- NCT00283738
- Testing
- BioSTAR Septal Repair Implant System
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- NMT Medical