Clinical trials: Intracutaneous Drug Delivery
Insomnia
Effects of Acupuncture and Intradermal Acupuncture on Insomnia
The aim of this clinical study is to observe the therapeutic effect of acupuncture and intradermal acupuncture in the treatment of insomnia Participants were randomized into the acupuncture group and control group.
- Trial name
- NCT01956760
- Testing
- Acupuncture and intradermal acupuncture
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Kyunghee University
Peripheral Neuropathic Pain, Nociceptive Pain
Determine the Effect of AZD3161,Injected Intradermally, on Quantitative Sensory Testing Variables in Normal and Ultraviolet-C (UVC) Exposed Skin in Healthy Volunteers
The purpose of this study is to investigate the effect of AZD3161 on mechanical pain sensitivity and axon reflex flare in normal and ultraviolet C irradiated skin.
- Trial name
- NCT01240148
- Testing
- AZD3161, Lidocaine
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Precocious Puberty, Treatment
A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty
A randomized controlled study will be conducted to evaluate the therapeutic effect of traditional Chinese medicine and acupoints stimulation on children with idiopathic precocious puberty.
- Conditions
- Precocious Puberty, Treatment, Alternative Medicine, Acupuncture
- Trial name
- NCT06510764
- Testing
- intradermal needles, Ziyinxiehuo Granules of traditional Chinese Medicine
- Where
- 2 sites in China
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Fudan University
HIV Infections
Evaluating the Safety and Immunogenicity of PENNVAX®-GP DNA Vaccine and IL-12 Plasmid, Delivered Via Intradermal or Intramuscular Electroporation in Healthy, HIV-Uninfected Adults
The study will evaluate the safety and tolerability of the PENNVAX®-GP HIV-1 DNA vaccine and interleukin 12 (IL-12) DNA adjuvant, given by intradermal (ID) or intramuscular (IM) injection with electroporation (EP), in healthy…
- Trial name
- NCT02431767
- Testing
- PENNVAX®-GP HIV-1 DNA vaccine, Interleukin-12 (IL-12) DNA adjuvant
- Where
- 4 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rhinitis, Allergic, Seasonal
Factors Predicting Efficacy of Allergen Injection Immunotherapy for Grass Pollen Hayfever
The purpose of this study is to determine at which point in the dosing regime grass pollen immunotherapy causes a significant reduction in the late skin response to allergen challenge.
- Trial name
- NCT00135629
- Testing
- Active injections of alum-adsorbed grass pollen vaccine (Alutard SQ)., Venepuncture: 100ml blood sample taken on 12 separate visits
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Skin Aging, Facial Aging
Objective Evaluation of Intradermal MSC-Derived Exosome Therapy on Facial Skin Quality
This study aims to evaluate the potential effects of mesenchymal stem cell-derived suspended exosome therapy on facial skin quality using objective imaging analysis.
- Conditions
- Skin Aging, Facial Aging, Skin Quality
- Trial name
- NCT07466953
- Testing
- Mesenchymal Stem Cell-Derived Exosome
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mert Ersan
Poliomyelitis
Immunogenicity and Safety of a Fractional Booster Dose of IPV Intradermally Versus Full Dose Intramuscularly
The purpose of this study is to investigate the use of a fourth fractional booster dose of sanofi pasteur's IMOVAX Polio injected intradermally (using the Mantoux technique) as booster dose between 15 to 18 months of age, in…
- Trial name
- NCT00885157
- Testing
- Inactivated types 1, 2, and 3 poliovirus, D antigens
- Where
- Philippines
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Healthy, Immunosuppressed
Pathophysiological Study of Characteristics of the Changes in the Cutaneous Immune System After Intradermal Antigen Injections
The goal of the vaccination is to induce humoral (antibody) and intracellular (T lymphocyte) responses. Various data show that intradermal vaccination is more efficient than intramuscular vaccination: the humoral response is…
- Trial name
- LBP003 (NCT00716989)
- Testing
- Tuberculin antigen
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Pain, Hyperalgesia
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia
To determine the effects of Lidocaine patch on the pain and hyperalgesia induced by intradermal capsaicin
- Trial name
- NCT00373893
- Testing
- Lidoderm Patch
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
HIV Infections
A Phase I/II Dose Escalation Study of Intradermal gp160 to Evaluate Safety, Delayed Type Hypersensitivity (Skin Test) Responses and Immunogenicity in Asymptomatic HIV Seropositive Patients With More Than 400 CD4+ Cells
To determine the safety of intradermal gp160 in HIV seropositive individuals who are asymptomatic and have a relatively intact immune system.
- Trial name
- NCT00000667
- Testing
- gp160 Vaccine (MicroGeneSys)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Evaluate Immune Responses Following mRNA COVID-19 Vaccine Administration Through Different Delivery Routes in Healthy Volunteers, SARS CoV-2
mRNA Covid-19 Vaccine Immune Response Comparisons Using Different Delivery Routes
The purpose of this study is to determine if immune responses differ when the mRNA COVID-19 vaccine is given through different delivery methods, including a needle-free injection system, or via intramuscular injection using…
- Trial name
- NCT06919796
- Testing
- COMIRNATY®
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- PharmaJet, Inc.
Influenza
Intracutaneous Delivery of Varied Dose Volumes of Saline
This study will evaluate intracutaneous delivery of 0.1, 0.25 and 0.5 milliliter volumes of saline from the FLUGEN 101.2 investigational microneedle-based device.
- Trial name
- NCT01767337
- Testing
- FLUGEN 101.2 device
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- FluGen Inc
Hepatitis B
ID HBV Vaccination With Imiquimod in OBI
During the course of chronic hepatitis B infection, patients may undergo hepatitis B surface antigen (HBsAg) seroclearance, resulting in undetectable circulating HBsAg.
- Trial name
- NCT03307902
- Testing
- Imiquimod + ID HBVv, Aqueous + ID HBVv, Imiquimod + IM HBVv
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Colorectal Cancer
Safety Study of DNA Vaccine Delivered by Intradermal Electroporation to Treat Colorectal Cancer
The purpose of this study is to evaluate the safety and immunogenicity of a CEA DNA immunisation approach in patients with colorectal cancer.
- Trial name
- El-porCEA (NCT01064375)
- Testing
- tetwtCEA DNA (wt CEA with tetanus toxoid Th epitope), Derma Vax (electroporation device), GM-CSF
- Where
- Sweden
- Volunteers
- 16 people
- Sponsor
- Maria Liljefors
Allergic Skin Reaction
Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP)
This study is designed to evaluate the allergenicity of Amphadase® in healthy volunteers using an intradermal skin test.
- Trial name
- H001-A2 (NCT01689363)
- Testing
- Hyaluronidase, Histamine, Saline
- Where
- 5 sites in United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
HIV Infections, HIV Seronegativity
HIV Candidate Vaccine, ALVAC-HIV-1, Administration in HIV-Negative Adults
The purpose of this study is to determine the best way to administer the candidate HIV vaccine, ALVAC HIV-1 (vCP205).
- Trial name
- NCT00013572
- Testing
- ALVAC-HIV MN120TMG (vCP205)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Gastroenteritis Escherichia Coli
Phase 1 Study of dmLT ID Vaccination in Healthy Adults
This study is to determine the safety and immunogenicity of an Enterotoxigenic Escherichia coli (ETEC) candidate vaccine, attenuated recombinant Double Mutant Heat-Labile Toxin (dmLT) from ETEC, administered by the Intradermal…
- Trial name
- NCT02531685
- Testing
- Recombinant Double Mutant Heat-Labile Toxin LT(R192G/L211A) (dmLT) Oral enterotoxigenic Escherichia coli (ETEC) Vaccine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes, Diabetes Mellitus
Biolinq Safety and Effectiveness Trial
The primary objective of the study is to evaluate the safety and effectiveness of the Biolinq MicroArray Intradermal Continuous Glucose Biowearable System, which is intended to be worn for up to five (5) days (up to 120 hours) in…
- Trial name
- NCT06229743
- Testing
- Biolinq System
- Where
- 6 sites in United States
- Volunteers
- 247 people
- Sponsor
- Biolinq Inc.
Music Therapy, Anxiety
Receptive Music Interventions During Intradermal Testing in Children
The study summary and design were to assess procedural anxiety and stress in parents and pain perception in children during intradermal testing.
- Conditions
- Music Therapy, Anxiety, Pain Management, Skin Tests
- Trial name
- NCT07013669
- Testing
- Receptive Music Therapy - Solfeggio Frequencies, Receptive Music Therapy - Traditional Turkish Music
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Hilal Gungor
Renal Colic, Urolithiasis
Sterile Water Injection vs Morphine for Renal Colic
This study aims to compare intradermal sterile water injections (ISWI) with intravenous morphine for pain relief in adults with acute renal colic caused by urinary stones.
- Trial name
- ISWI-Morph (NCT07378904)
- Testing
- Single Intradermal Sterile Water Injection, Multiple Intradermal Sterile Water Injections, Intravenous Morphine
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- University Tunis El Manar