Clinical trials: Intramuscular Injection, open to volunteers
Ulcer Foot, Mellitus Diabetes
The Prospective, Double-blind, Multicenter, Placebo-controlled, Randomized, Comparative Clinical Trial
The main objective of the study is to evaluate the efficacy and safety of Neovasculgen® in a course dose of 2.4 mg in combination with standard drug therapy in patients with unilateral neuroischemic form of diabetic foot syndrome.
- Trial name
- NCT07391319
- Testing
- Neovasculgen®
- Where
- Russia
- Volunteers
- 144 people
- Sponsor
- JSC NextGen
ASC-US, LSIL
Study of Treatment for HPV16+ ASC-US or LSIL
Phase I clinical trial to assess safety of pNGVL4aCRTE6E7L2 DNA and TA-CIN protein vaccinations, and to seek the appropriate dose of the pNGVL4aCRTE6E7L2 DNA vaccine
- Trial name
- PVX-6 (NCT03913117)
- Testing
- pNGVL4aCRTE6E7L2, TA-CIN
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Amputation, Amputation; Traumatic, Hand
Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation
The purpose of this research study is to see how well a new type of myoelectric prosthesis works. A myoelectric prosthesis is a robotic limb for amputees that is controlled by sensing the activity of muscles in the body above the…
- Trial name
- MIRA (NCT05768802)
- Testing
- Myoelectric Implantable Recording Array (MIRA)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boninger, Michael, MD
AI Chatbot, Nursing Education
The Effect of Artificial Intelligence-Supported Intramuscular and Subcutaneous Injection Training on Nursing Students
The complexity of healthcare services and technological advances today have necessitated the adoption of innovative approaches in nursing education.
- Conditions
- AI Chatbot, Nursing Education, AI (Artificial Intelligence), Nursing Skills
- Trial name
- NCT07253571
- Testing
- Training of IM and SC injection skills via Chatbot
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Rheumatoid Arthritis (RA)
Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall…
- Trial name
- STORM-RA (NCT07245732)
- Testing
- Glucocorticoid (GC)
- Where
- 5 sites in Canada
- Volunteers
- 220 people
- Sponsor
- Sunnybrook Health Sciences Centre
Malaria, Falciparum
Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants
This is a single-centre, participant- and investigator-blind, randomised, placebo controlled, single ascending dose study to assess the safety, tolerability and PK of a single dose of IM depot injection(s) of LAI formulations of…
- Trial name
- NCT07011511
- Testing
- MMV055 Dose 1, MMV055 Dose 2, MMV055 Dose 3
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Newborn Pain, Newborn Stress
Effect of Nesting During Intramuscular Injection on Pain, Stress, and Breastfeeding Success in Cesarean-Born Term Newborns
This randomized controlled trial aims to evaluate the effect of nesting during the first intramuscular injection on pain, stress level, physiological parameters, settling time, and breastfeeding success in healthy term newborns…
- Conditions
- Newborn Pain, Newborn Stress, Breastfeeding Success in Newborns
- Trial name
- NESTING (NCT07748520)
- Testing
- Nesting
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Healthy Subjects
Intramuscular Temperature on the Echo-textural Characteristics
Echointensity and echotexture have been used as a physiological marker for changes in skeletal muscle quality and structure caused by physical training, low activity, ageing and some neuromuscular disorders.
- Trial name
- NCT06145646
- Testing
- Muscle warm-up
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Tetanus
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection
A Randomized, Double-blind, Controlled, Dose-escalation Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Intramuscular Injection of Recombinant Human Anti-tetanus…
- Trial name
- NCT07149454
- Testing
- Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection, Human Tetanus Immunoglobulin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
Ventrogluteal Injections
Lying Positions in Intramuscular Injection
The aim of this study is to examine the effects of intramuscular (IM) injections administered in three different lying positions (supine, prone, and lateral) into the ventrogluteal site on patient pain, comfort, and procedural…
- Trial name
- Lying (NCT07586605)
- Testing
- Lying before procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- University of Yalova
Healthy Adult Participants
Pharmacokinetics and Relative Bioavailability of Intranasal vs Intramuscular Olanzapine in Healthy Adult Participants
This is a Phase 1, open-label, 5-period, 2-sequence, single ascending dose study designed to assess the pharmacokinetics, dose proportionality, safety, and tolerability of NRL-1004 (olanzapine nasal spray), and to assess the…
- Trial name
- NCT07921966
- Testing
- NRL-1004 2.5 mg, ZYPREXA IM 10mg, NRL-1004 5.0 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurelis, Inc.
Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy
Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients
The pathophysiological process common to neuropathies is fatty replacement of muscle tissue, more commonly known as intramuscular fat fraction (F.F).
- Conditions
- Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy, Acquired Demyelinating Neuropathy
- Trial name
- IMAGINERV (NCT06845644)
- Testing
- Quantitative neuromuscular MRI, Neuromuscular ultrasound
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder)
Ultrasound Assessment of Gluteal Muscle in Patients Receiving Depot Antipsychotics and Healthy Volunteers
This observational study will use ultrasound to assess the gluteal musculature in patients receiving depot antipsychotic medication and in healthy volunteers.
- Conditions
- Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder), Intramuscular Injection
- Trial name
- ULPSYK (NCT07815587)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Syphilis Infection, Benzathine Penicillin Adverse Reaction
LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment
There is evidence to suggest that lidocaine can help reduce the pain associated with intramuscular injections of benzathine penicillin G (BPG) or Bicillin, used to treat syphilis infections.
- Trial name
- LIMIT (NCT06391125)
- Testing
- normal Saline, Lidocaine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Evaluate Immune Responses Following mRNA COVID-19 Vaccine Administration Through Different Delivery Routes in Healthy Volunteers, SARS CoV-2
mRNA Covid-19 Vaccine Immune Response Comparisons Using Different Delivery Routes
The purpose of this study is to determine if immune responses differ when the mRNA COVID-19 vaccine is given through different delivery methods, including a needle-free injection system, or via intramuscular injection using…
- Trial name
- NCT06919796
- Testing
- COMIRNATY®
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- PharmaJet, Inc.
Injection Techniques, Nursing Interventions
Traction, Pressure, and Rapid Muscle Release (TPR) Technique During Intramuscular Injection: Effects on Pain and Patient Satisfaction
This study will be conducted to evaluate the effect of the Traction, Pressure, and Rapid Muscle Release (TPR) technique, an innovative method used during intramuscular vitamin B12 (cyanocobalamin) injections, on patients' pain…
- Conditions
- Injection Techniques, Nursing Interventions, Injection Pain Prevention, Patient Satisfaction
- Trial name
- TPRTDIMI (NCT07499687)
- Testing
- TPR Injection Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Traumatic Brain Injury
Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults
Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head…
- Trial name
- CRASH-4 (NCT04521881)
- Testing
- Tranexamic Acid 500 MG
- Where
- 2 sites in United Kingdom
- Volunteers
- 5,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Blood Loss After a Total Hip Replacement
Evaluating the Effectiveness of Intramuscular Versus Intravenous Tranexamic Acid for Minimizing Blood Loss After Total Hip Arthroplasty: A Randomized Controlled Trial
Intramuscular vs. Intravenous Tranexamic Acid for Total Hip Arthroplasty
- Trial name
- NCT07817537
- Testing
- Tranexamic Acid (TXA) intarmuscular, Tranexamic Acid (TXA) intravenous
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dysmenorrhea, Pain
The Effect of Distraction Techniques Used in Intramuscular (IM) Injections on Pain in Adolescents Presenting to the Emergency Department With Dysmenorrhea: A Randomized Controlled Study
Brief Summary: This study investigates the effectiveness of non-pharmacological techniques for managing dysmenorrhea (menstrual pain) in adolescents.
- Conditions
- Dysmenorrhea, Pain, Distraction Methods
- Trial name
- "HSTT-SB Dysme (NCT06842329)
- Testing
- Halfer Skin Tape Technique, ShotBlocker Technique, Standard Intramusculer injection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Duygu MEZDE