Clinical trials: Intramuscular Injection, open to volunteers
Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy
Longitudinal Quantitative Neuromuscular MRI in Neuropathic Patients
The pathophysiological process common to neuropathies is fatty replacement of muscle tissue, more commonly known as intramuscular fat fraction (F.F).
- Conditions
- Charcot-Marie-Tooth Neuropathy Type 1A, Hereditary Transthyretin Amyloid Neuropathy, Acquired Demyelinating Neuropathy
- Trial name
- IMAGINERV (NCT06845644)
- Testing
- Quantitative neuromuscular MRI, Neuromuscular ultrasound
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Measles, Measles-Mumps-Rubella+Chickenpox Vaccine
A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age
This study is evaluating the immunogenicity and safety of intramuscular administration of the investigational MMRVNS vaccine compared to intramuscular administration of the MMRV (Merck's measles, mumps, rubella and varicella)…
- Trial name
- NCT07406360
- Testing
- MMRVNS, MMRV
- Where
- 17 sites in United States
- Volunteers
- 1,209 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tetanus
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection
A Randomized, Double-blind, Controlled, Dose-escalation Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Intramuscular Injection of Recombinant Human Anti-tetanus…
- Trial name
- NCT07149454
- Testing
- Recombinant Human Anti-Tetanus Toxin Monoclonal Antibody Injection, Human Tetanus Immunoglobulin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Lanzhou Institute of Biological Products Co., Ltd
Rabies (Healthy Volunteers)
Boostability Assessment of Three Rabies Pre-Exposure Regimens in Healthy Volunteers 5 Years Following Priming.
A multicentre, open label trial in healthy volunteers to assess the boostability of three different rabies pre-exposure prophylaxis regimens (2 x 1IM regimen, 2 x 2 ID regimen, 1 x 2 ID regimen) when administering a single-dose…
- Trial name
- BAZOOKA_221 (NCT07455318)
- Testing
- Booster vaccination
- Where
- 6 sites in Belgium
- Volunteers
- 561 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Suicidal Ideation
Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency Department
Participants are asked to take part in this research study after coming to the Emergency Department with thoughts or behaviors of seriously hurting themselves.
- Trial name
- ASPIRED (NCT07868913)
- Testing
- Ketamine Injectable Solution, Crisis Response Plan, Safety Planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Rheumatoid Arthritis (RA)
Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall…
- Trial name
- STORM-RA (NCT07245732)
- Testing
- Glucocorticoid (GC)
- Where
- 5 sites in Canada
- Volunteers
- 220 people
- Sponsor
- Sunnybrook Health Sciences Centre
Physical Performance Decline in Older Adults, Sarcopenia
Clinical Relevance of Ultrasound-based Intramuscular Fat Infiltration Assessment in Hospitalized Older Adults (FATUS-OLD)
Sarcopenia in older adults is associated not only with loss of muscle mass but also with deterioration of muscle quality, particularly intramuscular fat infiltration.
- Conditions
- Physical Performance Decline in Older Adults, Sarcopenia, Muscle Fat Infiltration
- Trial name
- FATUS-OLD (NCT07411547)
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Nantes University Hospital
Oculopharyngeal Muscular Dystrophy
A Study to Evaluate the Safety and Clinical Activity of Intramuscular Doses of BB-301 Administered to Subjects With Oculopharyngeal Muscular Dystrophy With Dysphagia
Subjects who have enrolled in the oculopharyngeal muscular dystrophy (OPMD) natural history study (Study BNTC-OPMD-NH-001) and have completed at least 6 months of follow up in Study BNTC-OPMD-NH-001 may be eligible to participate…
- Trial name
- NCT06185673
- Testing
- BB-301: Dose escalation phase 1b cohort 1, BB-301: Dose escalation phase 1b cohort 2, BB-301: Dose escalation phase 1b cohort 3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Benitec Biopharma, Inc.
Postpartum Hemorrhage
Tranexamic Acid to Prevent Heavy Bleeding After Childbirth in Women At Higher Risk
Heavy bleeding after childbirth, known as a postpartum haemorrhage (PPH), causes about 70,000 maternal deaths every year. Tranexamic acid (TXA) is a lifesaving treatment for women with PPH.
- Trial name
- I'M-WOMAN (NCT05562609)
- Testing
- Tranexamic acid
- Where
- Tanzania
- Volunteers
- 30,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Pain, Fear
Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection
Intramuscular injection is one of the most common invasive procedures in childhood and is frequently associated with pain and fear.
- Trial name
- NCT07468227
- Testing
- Helfer skin tab, Vibration Buzzy Bee
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people
- Sponsor
- Ege University
AI Chatbot, Nursing Education
The Effect of Artificial Intelligence-Supported Intramuscular and Subcutaneous Injection Training on Nursing Students
The complexity of healthcare services and technological advances today have necessitated the adoption of innovative approaches in nursing education.
- Conditions
- AI Chatbot, Nursing Education, AI (Artificial Intelligence), Nursing Skills
- Trial name
- NCT07253571
- Testing
- Training of IM and SC injection skills via Chatbot
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Procedural Pain, Pain-related Fear
Distraction Cards Versus Emotion-Regulation Toy Squeezing During Intramuscular Vaccination in Preschool Children
This single-center, parallel-group, randomized experimental study will compare the effects of two active non-pharmacological interventions - distraction-card use and emotion-regulation toy squeezing - on procedural pain and…
- Trial name
- NCT07669961
- Testing
- Distraction-Card Group, Emotion-Regulation Toy-Squeezing Group
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Mersin University
Norovirus Infections, Norovirus Gastroenteritis
A Study to Evaluate INT101 in Healthy Adults for the Prevention of Norovirus Gastroenteritis
This study is being conducted to evaluate the safety and immunogenicity of INT101, an investigational vaccine intended to prevent norovirus gastroenteritis, in healthy adults.
- Trial name
- INT-101 (NCT07818629)
- Testing
- INT101 Low Dose, INT101 High Dose
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- InThera Inc. Korea
Nursing Students, Intramuscular Injection
Effect of Microteaching on Ventrogluteal Injection Training
Nursing education plays a crucial role in ensuring nurses possess the necessary knowledge and skills to provide high-quality care.
- Trial name
- NCT06884124
- Testing
- Experimental, Control
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Dysmenorrhea, Pain
The Effect of Distraction Techniques Used in Intramuscular (IM) Injections on Pain in Adolescents Presenting to the Emergency Department With Dysmenorrhea: A Randomized Controlled Study
Brief Summary: This study investigates the effectiveness of non-pharmacological techniques for managing dysmenorrhea (menstrual pain) in adolescents.
- Conditions
- Dysmenorrhea, Pain, Distraction Methods
- Trial name
- "HSTT-SB Dysme (NCT06842329)
- Testing
- Halfer Skin Tape Technique, ShotBlocker Technique, Standard Intramusculer injection
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Duygu MEZDE
Low Back Pain, Mechanical
Comparison of the Efficacy of Diclofenac Sodium and Subcutaneous 5% Dextrose Injection in Low Back Pain.
The aim was to compare the effectiveness of intramuscular diclofenac sodium and subcutaneous 5% dextrose injection in patients presenting to the emergency department with low back pain using the visual analog scale (VAS).
- Trial name
- NPT (NCT06829030)
- Testing
- 5% dextrose prolotherapy, Diclofenac 75mg/ml
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aksaray University Training and Research Hospital
Shigella Infection
Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants
The goal of this phase 1/2a, randomized, observer-blind, age-descending, dose-finding trial is to evaluate the safety and immunogenicity of a quadrivalent synthetic oligosaccharide-based Shigella vaccine (adjuvanted IP-QSV) in…
- Trial name
- NCT07666750
- Testing
- 30μg IP-QSV, 10μg IP-QSV, 2μg IP-QSV
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Breast Cancer, Pain Management
Nonpharmacological Management of Pain and Fear During Hormone Injection in Breast Cancer Patients
This randomized controlled study will compare the effects of the ShotBlocker device and the Helfer Skin Tap Technique on pain and fear during intramuscular hormone injections in premenopausal and postmenopausal breast cancer…
- Conditions
- Breast Cancer, Pain Management, Fear, Injection Fear
- Trial name
- NCT07406165
- Testing
- ShotBlocker device, This involves rhythmic, gentle tapping with the fingertips on the skin surrounding the gluteal injection site.
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Inonu University