Clinical trials: Intraocular Inflammation, open to volunteers
Behcet Disease
Asprosin in Behect Patients
This study aims to investigate serum Asprosin concentrations in patients with BD and their relationship with disease activity and major clinical manifestations.
- Trial name
- NCT07803198
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Systemic Lupus Erythematosus, Inflammatory Myopathy
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
The objective of this study is to evaluate the efficacy and safety of BCMA/CD19 chimeric antigen receptor (CAR)-modified T cells in the treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Inflammatory Myopathy, Systemic Sclerosis (SSc), ANCA-associated Vasculitis
- Trial name
- NCT06794008
- Testing
- BCMA-CD19 CAR-T therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Noninfectious Uveitis
The Microbiome in Uveitis and Pediatric Inflammatory Diseases
Chronic, noninfectious uveitis in children, associated with various systemic inflammatory diseases, carries a high risk of vision loss.
- Trial name
- MUMIP (NCT07885501)
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasculitis, Behcet's Disease
Vasculitis Pregnancy Registry
The purpose of this study is to learn about the experience of women with vasculitis who become pregnant. In particular, the study will consist of several online surveys to assess 1.
- Conditions
- Vasculitis, Behcet's Disease, CNS Vasculitis, Cryoglobulinemic Vasculitis
- Trial name
- V-PREG (NCT02593565)
- Testing
- Online questionnaires
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Takayasu Arteritis, Behçet's Disease
Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
Systemic vasculitis refers to a group of rare diseases characterized by inflammation of blood vessel walls, which may cause ischemia and structural damage in various organs.
- Conditions
- Takayasu Arteritis, Behçet's Disease, Healthy Controls
- Trial name
- NCT07276087
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ÖZLEM NUR TOK YAMAN
Uveitis
A Study of Uveitis in Children <18 Years of Age
The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis.
- Trial name
- UV1 (NCT07518134)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- Jaeb Center for Health Research
Inflammation, Uveitis
Safety, Tolerability, and Distribution of Laquinimod Eye Drops : The LION Study
The LION Study is a prospective, single-center phase 1 clinical trial to evaluate the safety, tolerability, and distribution of Laquinimod administered as topical eye drops for two weeks in human participants.
- Trial name
- LION (NCT06161415)
- Testing
- Laquinimod eye drops
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Quan Dong Nguyen
Behcet Syndrome, Intestinal Type
Baricitinib in the Treatment of Intestinal Behçet's Syndrome
This study aims to conduct a randomized controlled trial to compare the efficacy and safety of Baricitinib and Adalimumab (ADA) in the treatment of refractory intestinal Behçet's Syndrome (BS).
- Trial name
- NCT06849908
- Testing
- Baricitinib, Adalimumab
- Where
- 2 sites in China
- Volunteers
- 56 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Inflammatory Disease, Angioedema
Deployment o the Multidisciplinary Prospective Cohort Imminent
Immune-mediated inflammatory diseases (IMIDs) most often affect young patients and have high impact on morbidity and mortality with a significant alteration in the quality of life of patients with professional, social and…
- Conditions
- Chronic Inflammatory Disease, Angioedema, Severe Asthma, Lupus
- Trial name
- IMMINeNT (NCT04334031)
- Testing
- Biobanking with genetic analysis, SF-12 questionnaire
- Where
- France
- Volunteers
- 2,200 people
- Sponsor
- University Hospital, Lille
Uveitis
PANDA-ASOCT: Paediatric Anterior Uveitis Detection With Automated Image Analysis Using ASOCT
Uveitis is an inflammation inside the eye. Although rare, it is an important auto-inflammatory eye condition that affect children and young people (CYP).
- Trial name
- PANDA (NCT07813598)
- Testing
- Slit Lamp Examination, Anterior segment ocular coherence tomography (ASOCT)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Non Infectious Uveitis
A Proof-of-concept Trial to EvaluAte the efficaCy and Safety Of Cell Therapy TRX103 in Patients With Active, Non-infectious Uveitis
The purpose of this Phase 1, first in uveitis open-label study is to assess the safety and tolerability of TRX-103 in patients with non infectious uveitis (NIU).
- Trial name
- PEACOCX (NCT07427628)
- Testing
- TRX103
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Quan Dong Nguyen
Behcet Disease, Obesity
Diet Restiction in Subjects With Behcet Disease and Complaint of Tinnitus
otogic problems are varied in bechet disorder, tinnnitus is one of these problems. obesity may increase this probelm
- Conditions
- Behcet Disease, Obesity, Subjective Tinnitus
- Trial name
- NCT07702149
- Testing
- diet restriction
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pericarditis, Tako-TSUBO Cardiomyopathy
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
INFLAME-BANK is a French multicenter prospective observational ancillary study of the international EACVI-INFLAME project. It aims to establish a biobank and perform immunophenotyping and proteomic analyses in patients with…
- Conditions
- Pericarditis, Tako-TSUBO Cardiomyopathy, Myocarditis, Inflammatory Cardiomyopathies
- Trial name
- INFLAME-BANK (NCT07737470)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behcet's Disease, Idiopathic Inflammatory Myopathies
Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases
Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) is limited due to small patient populations.
- Conditions
- Behcet's Disease, Idiopathic Inflammatory Myopathies, IgG4-related Disease
- Trial name
- DRIMID (NCT06285539)
- Testing
- Filgotinib
- Where
- 6 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Non-infectious Uveitis
Prospective CoHoRt Of Non-infectious Intermediate, pOsterior or panuveitiS
prospective, cohort, longitudinal, multicenter, non-randomized study of patients with non-infectious posterior segment uveitis or panuveitis, with a group of control patients (scheduled for cataract or vitreoretinal surgery) and…
- Trial name
- CHRONOS (NCT05928754)
- Testing
- care strategy
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Behcet's Uveitis
"Comparison of the Efficacy and Safety of Adalimumab to That of Tocilizumab in Severe Uveitis of Behçet's Disease"
UVB, is the first randomized prospective, head to head study, comparing Adalimumab to Tocilizumab in sight threatening uveitis of Behçet's Disease (BD). Anti-TNFα has been used for BD uveitis for 15 years.
- Trial name
- UVB (NCT05874505)
- Testing
- Adalimumab, Tocilizumab
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infectious Panuveitis, Infectious Iridocyclitis
Pathogen Detection in Infectious Uveitis
Infectious uveitis is a very important blinding disease. Some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye.
- Trial name
- NCT04521673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Behcet Disease
Behcet Disease Patients With Pulmonary Endoarterectomy: Outcomes of Program of Inspiratory Msucle Trianing
physical complications are common in Behcet disease patients with pulmonary endoarterectomy, so outcomes of program of inspiratory msucle trianing must be investigated
- Trial name
- NCT07662603
- Testing
- inspiratory muscle trianing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Uveitis
Efficacy and Safety of Adalimumab Plus Medium Dose Oral Glucocorticosteroid for Refractory Behçet's Uveitis
This study is a multi-center randomized non-inferiority study that aims to observe the short-term (3 months) efficacy and safety of adalimumab plus medium-dose glucocorticosteroid (30mg/d prednisone or equivalent) with slow…
- Trial name
- NCT05105347
- Testing
- Adalimumab plus different doses of oral glucocorticosteroid
- Volunteers
- 130 people
- Sponsor
- Peking Union Medical College Hospital
Behcet Disease, Cranial Nerve Disorder
Cranial Nerve Functions in Behçet's Disease and Their Relationship With Clinical Parameters
The goal of this study is to find out whether cranial nerves are affected in people with Behçet's Disease (BD), and how this might relate to other disease features.
- Trial name
- NCT07135063
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University