Clinical trials: Intraocular Lens Implant
Cataract, Astigmatism
Post-Approval Study of the TECNIS® Toric Extended Cylinder Range Intraocular Lens (IOL)
This study is a prospective, multicenter, bilateral, non-randomized, open-label, clinical study conducted at up to 20 sites in the USA.
- Trial name
- NCT02649842
- Testing
- TECNIS Toric Models ZCT450, ZCT525 or ZCT600
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Cataract, Presbyopia
Retrospective / Prospective Clinical Study of AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric Intraocular Lenses
The purpose of this study is to characterize the safety and effectiveness of the ACRYSOF IQ ReSTOR +2.5 diopter (D) Multifocal Toric Intraocular Lens (IOL) in subjects at least 3 months and no more than 14 months after IOL…
- Conditions
- Cataract, Presbyopia, Corneal Astigmatism
- Trial name
- NCT02176343
- Testing
- AcrySof® IQ ReSTOR® +2.5 D Multifocal Toric IOL
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Cataract
Effect of Blue Light Filtration on Visual Performance
The purpose of this study is to evaluate photostress recovery with blue light filter clip-on glasses among pseudophakes [ie, subjects in which the natural lens of the eye has been replaced with an artificial lens (intraocular…
- Trial name
- NCT01938989
- Testing
- Clear clip-on glasses, Blue light filter clip-on glasses
- Volunteers
- 158 people
- Sponsor
- Alcon Research
Cataract
Evaluation of Quality of Vision and Visual Outcomes With Bilateral Implantation of the Clareon PanOptix Intraocular Lens
To evaluate visual outcomes and quality of vision following bilateral implantation of the Clareon PanOptix intraocular lens (IOL) targeted for emmetropia.
- Trial name
- NCT05518539
- Testing
- The Clareon™ PanOptix™ Trifocal (toric and non-toric models)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Newsom Eye & Laser Center
Cataract
Clinical Investigation of the Bi Flex M Multifocal IOL
During cataract surgery an artificial lens is implanted in the eye. These artificial lenses are called intraocular lenses (IOLs) and there are many different types of IOL designs.
- Trial name
- NCT02338882
- Testing
- Bi flex M multifocal intraocular lens, Bi flex 1.8 monofocal intraocular lens
- Volunteers
- 100 people
- Sponsor
- Dr Phillip J Buckhurst
Aphakia, Corneal Astigmatism
Clinical Investigation of an AcrySof IQ PanOptix Toric Intraocular Lens
The purpose of this study is to evaluate the effectiveness and safety of the TFNT20 low cylinder power intraocular lens when implanted in the eye to replace the natural lens following cataract removal.
- Trial name
- NCT04542525
- Testing
- ACRYSOF IQ PanOptix Toric Trifocal IOL, Cataract surgery
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Alcon Research
Intraocular Lens Associated Postoperative Inflammation
Dropless™ vs. Less Drops™ Pharmaceutical Regimens After Cataract Surgery
To compare the relative effectiveness of the Imprimis Dropless™ (TriMoxiVanc) intraocular solution with the Less Drops™ topical formulation of PredMoxiKeterolac (given for the first week post op) followed by PredKeterolac (given…
- Trial name
- NCT02819908
- Testing
- Imprimis Dropless, Imprimis Less Drops
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Eye Center of North Florida
Cataract
Postmarket Study of an Intraocular Lens Power Selection System
The purpose of the study was to evaluate the visual acuity outcomes when using the Optiwave Refractive Analysis (ORA) with VerifEye+ and Barrett Toric Calculator for calculating intraocular lens (IOL) power and axis in subjects…
- Trial name
- NCT03579433
- Testing
- ORA with VerifEye+, Alcon Barrett Toric Calculator, Acrysof® IQ Toric IOL
- Where
- 9 sites in United States
- Volunteers
- 124 people
- Sponsor
- Alcon Research
Cataract, Corneal Astigmatism
Evaluation of the Rotational Stability of the Tecnis Toric II IOL
This is a prospective, multicenter, single-arm, open-label clinical study of the commercially available TECNIS Toric II IOL. The study will be conducted in up to 192 subjects needing unilateral or bilateral cataract surgery in up…
- Trial name
- STEELE (NCT04327518)
- Testing
- TECNIS® Toric II
- Where
- 7 sites in United States
- Volunteers
- 125 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataract
Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Delivery Prior to Implantation of a Posterior Chamber IOL
The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery System (EGDS) compared to placebo in patients…
- Trial name
- NCT01602068
- Testing
- Dexamethasone Phosphate Ophthalmic, 100 mM Sodium Citrate Buffer
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Cataract Bilateral, Presbyopia
Tecnis ZLB00 & Symfony Intraocular Lens Combination Outcomes
Current visual outcomes expectations of cataract patients are similar to those of refractive surgery patients. Their desire is to be spectacle independent for far, intermediate and near vision activities.
- Trial name
- NCT03771274
- Testing
- Tecnis ZLB00 & Symfony IOL
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Cataract
Comparison of Visual Outcomes With Mini-Monovision Between a Monofocal and an Adjustable Intraocular Lens
This study is a single center, multi-surgeon, prospective, randomized, comparative study of binocular corrected distance visual acuity (CDVA) after successful bilateral cataract surgery.
- Trial name
- NCT06122103
- Testing
- Clareon Monofocal, Light-Adjustable Lens
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Cataract
Pilot Study of AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric Intraocular Lens (IOL)
The purpose of this study is to describe visual outcomes, in particular spherical equivalent by manifest refraction and visual acuity across a range of distances, 6 months post implantation of the AcrySof® IQ ReSTOR® +3.0 D…
- Trial name
- NCT01200511
- Testing
- AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL
- Volunteers
- 49 people
- Sponsor
- Alcon Research
Aphakia
Clinical Investigation of the AcrySof IQ Vivity Extended Vision Intraocular Lens (IOL)
The purpose of this study is to compare the visual disturbance profile of an intraocular lens (IOL) using nondiffractive optics, the VIVITY IOL, to two diffractive IOLs in subjects requiring bilateral cataract surgery.
- Trial name
- NCT04098367
- Testing
- VIVITY, SYMFONY, AT LARA
- Where
- 12 sites in Australia, New Zealand
- Volunteers
- 222 people
- Sponsor
- Alcon Research
Cataract, Corneal Astigmatism
ClarVista HARMONI Toric Trial With Intraoperative Exchange
The purpose of this study was to demonstrate the safety and effectiveness of the HARMONI® Modular Intraocular Lens System with a toric optic in subjects with pre-existing corneal astigmatism in need of cataract surgery.
- Conditions
- Cataract, Corneal Astigmatism, Aphakia
- Trial name
- NCT03054649
- Testing
- HARMONI® Modular Intraocular Lens System, Intraoperative optic exchange
- Where
- 2 sites in Mexico, Philippines
- Volunteers
- 44 people
- Sponsor
- ClarVista Medical
Cataract
Clinical Investigation of the Next Generation Intraocular Lens
An investigational IOL designed to provide improved intermediate and near visual acuity and decreased spectacle wear was evaluated for safety and effectiveness in a six-month study.
- Trial name
- NCT03500198
- Testing
- Investigational Intraocular Lens Device #1: Next Generation TECNIS IOL, Control Monofocal Intraocular Lens: TECNIS Monofocal IOL
- Where
- 10 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataract
Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00
The purpose of this study is to investigate visual outcomes and assess safety at 12 months (330-420 days) post bilateral implantation of the AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL.
- Trial name
- NCT02529488
- Testing
- AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL
- Volunteers
- 167 people
- Sponsor
- Alcon Research
Cataract, Corneal Astigmatism
Clinical Investigation of the Safety and Effectiveness of an Investigational Model of the TECNIS® Intraocular Lens
This study will be a prospective, multicenter, bilateral, comparative, three-way masked (Sponsor, subject and evaluator), randomized clinical investigation conducted at up to 15 sites.
- Trial name
- BRAVO (NCT03949335)
- Testing
- IOL Model ZFR00V, IOL Model ZCB00
- Where
- 15 sites in United States
- Volunteers
- 272 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataracts
Clinical Investigation of the TECNIS® Next-Generation Intraocular Lens, Model DEN00V
Prospective, multicenter, bilateral, masked (sponsor, subject and evaluator), randomized clinical trial to evaluate the safety and effectiveness of the TECNIS IOL, Model DEN00V in comparison to an aspheric monofocal IOL.
- Trial name
- NCT05574959
- Testing
- investigational IOL Model DEN00V, control IOL Model ZCB00/DCB00
- Where
- 10 sites in United States
- Volunteers
- 243 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Cataract
Optimizing the Assessment of Refractive Outcomes After Cataract Surgery
The purpose of this study is to evaluate current available assessments (automated vs. manual) with which manifest refraction data and biometric variables are obtained to understand if data from an automated refractor can be…
- Trial name
- NCT02842151
- Testing
- Manifest refraction, ACRYSOF® IQ Monofocal IOL Model SN60WF, Topcon® KR-1W Wave-Front Analyzer
- Volunteers
- 162 people
- Sponsor
- Alcon Research