Clinical trials: Intraoperative Care
Anesthesia, Peroperative Complication
Protective Ventilation Based on Alveolar Ventilation in Children
Protective ventilation decreased morbidity and mortality in adults' patients and is now a standard of care in intensive care unit and in anesthesiology.
- Trial name
- PROVENTIPED (NCT03901599)
- Testing
- Alveolar ventilation monitoring estimated by the capnographic ventilation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Intra-operative Hypotension
Preoperative Point of Care Ultrasound Guided Fluid Optimization and Intravenous Ondansetron to Prevent General Anesthesia-Induced Hypotension
Hypotension is a common side-effect of general anesthesia induction and is related to adverse outcomes including significantly increasing risk of one-year mortality.
- Trial name
- NCT05784350
- Testing
- fluid boluses guided by IVC diameter via US/administration of pre-operative IV Odansetrone
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Meir Medical Center
Complication
Data Registry of Intensive Care Unit (ICU) Siamitra and Intensive Care Unit (ICU) Salad-Samung
As a general surgical intensive care units of the biggest tertiary referral university of Thailand with more than 1,000 admissions/year, recently, more complicated perioperative care surgical patients were accepted with high…
- Trial name
- NCT01361477
- Where
- 2 sites in Thailand
- Volunteers
- 2,000 people
- Sponsor
- Mahidol University
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
General Anesthesia, Intraoperative Monitoring
Analysis of Breath Sounds During Surgery
This study aims to analyze breath sounds during surgery by using electronic stethoscope sensors attached to patients under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Monitoring, Respiratory Sounds
- Trial name
- BREATHSOUND (NCT07280546)
- Testing
- Electronic stethoscope monitoring
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
Enhanced Perioperative Care for the Prevention of Colorectal Anastomotic Leakage
This multicenter open-label trial is designed to evaluate if the implementation of an enhanced peri-operative care protocol results in an optimal intraoperative condition of the patient and in a decrease in incidence of…
- Conditions
- Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum, Intraoperative Awareness
- Trial name
- DOUBLE CHECK (NCT05250882)
- Testing
- Enhanced perioperative care protocol
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 1,600 people
- Sponsor
- Amsterdam UMC, location VUmc
Arthritis of Knee, Arthritis of Hip
Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy
The present study is a prospective, multi-center observational trial comparing the times taken to diagnose coagulopathies using point-of-care (POC) viscoelastic tests or standard central laboratory tests (SCL tests) in patients…
- Conditions
- Arthritis of Knee, Arthritis of Hip, Spine, Prostate Cancer
- Trial name
- NCT06637943
- Testing
- SCL tests, POC viscoelastic tests
- Where
- 4 sites in South Korea
- Volunteers
- 210 people
- Sponsor
- Konkuk University Medical Center
Hepatectomy, Transfusion Requirements
Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project
The goal of this clinical trial is to determine if implementing a controlled blood removal protocol (i.e. hypovolemic phlebotomy [HP] where approximately 10% of the patient's blood is removed and reinfused following hepatic…
- Conditions
- Hepatectomy, Transfusion Requirements, Intraoperative Bleeding, Intraoperative Monitoring
- Trial name
- NCT07629648
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD, FRCPC)
Remimazolam, Propofol
Comparison of Recovery Profiles Among Propofol, Remimazolam, and Dexmedetomidine After Intraoperative Sedation
A total of 120 patients (American Society of Anesthesiologist Physical Status 1-3) who signed a consent form among patients aged 19-80 years who are scheduled to undergo brachial plexus block and upper extremity surgery under…
- Conditions
- Remimazolam, Propofol, Dexmedetomidine, Orthopedic Procedures
- Trial name
- NCT05688345
- Testing
- Remimazolam, Propofol, Dexmedetomidine
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Asan Medical Center
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Anesthesia
Impact of NOL Intraoperative Guided Fentanyl Analgesia vs SCC for Elective Major Abdominal Surgery
Recently, a newly developed index, the Nociceptive Level (NOL) index, was validated and showed superiority over heart rate and blood pressure for recognition and grading of intense and mild nociceptive stimuli during surgery…
- Trial name
- NCT03970291
- Testing
- PMD-200
- Where
- Israel
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Medasense Biometrics Ltd
Gynecologic Laparoscopic Surgery, Hysterectomy
Impact of Nociceptive-Level (NOL) Intraoperative Guided Analgesia During Gynecological Laparoscopic Surgery Under General Anesthesia
The aim of the present study is to show that the use of the NOL device in addition to the Standard of Care (based on mean arterial blood pressure and heart rate values) to guide the administration of opioids compared to the…
- Conditions
- Gynecologic Laparoscopic Surgery, Hysterectomy, Oophorectomy
- Trial name
- NOLGYN (NCT03776838)
- Testing
- Intravenous Fentanyl guided by SoC+NOL, Intravenous Fentanyl guided by SoC
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Surgical Injury, Stress, Physiological
Effect of a Bundle of Non-pharmacological Interventions on the Stress Response to Surgery
Rationale: Surgical trauma and post-surgical pain induce a physiological stress response that can be detrimental to the patient.
- Conditions
- Surgical Injury, Stress, Physiological, Stress, Psychological, Pain, Postoperative
- Trial name
- SPACU-lab (NCT05638152)
- Testing
- implementation of a bundle of non-pharmacological interventions aimed at stress reduction
- Volunteers
- 90 people
- Sponsor
- The Netherlands Cancer Institute
Gastric Cancer, Gastric Adenocarcinoma
Evaluation of Intra-operative Photographs for the Assessment of a Proper Lymphadenectomy in Minimally-invasive Gastrectomies for Gastric Cancer (PhotoNodes)
Even after the wide introduction of chemo/radiotherapy in the treatment algorithm, adequate surgery remains the cornerstone of gastric cancer treatment with curative intent.
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Lymphadenectomy, Minimally Invasive Surgery
- Trial name
- PhotoNodes (NCT06466902)
- Testing
- Quality assessment of D2 lymphadenectomy using the PhotoNode Score
- Where
- 8 sites in Italy
- Volunteers
- 326 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Pain, Postoperative
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
The purpose of this study is to compare two medications currently injected intra-operatively to help decrease pain after surgery in patients undergoing a primary total hip replacement (THR).
- Trial name
- NCT03001453
- Testing
- Liposomal Bupivacaine, 0.25% Bupivacaine with epinephrine, Saline
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- American Hip Institute
Diabetes, Hyperglycemia
Comparison of Intraoperative Best Practice Advisory Reminders to Protocolize Insulin Administration Versus Standard Care in Patients at High Risk of Hyperglycemia
This study will assess the implementation of a glucose management clinical decision support tool. The specific objective is to determine if supplementing the existing glucose check reminder with a best practice advisory (BPA), an…
- Trial name
- NCT05426096
- Testing
- Best Practice Advisory
- Where
- United States
- Volunteers
- 7,232 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Complications
Intraoperative Anesthesia Care Transition Checklist
Perioperative management decisions must often be made quickly and rely on practitioners having relevant facts at hand. During transitions of patient care between anesthesia providers, known as "handovers," information may not be…
- Trial name
- NCT02453828
- Testing
- Non-cardiac surgery
- Where
- United States
- Volunteers
- 7,348 people
- Sponsor
- The Cleveland Clinic
Histologically Confirmed Localized Prostate Cancer, Scheduled to Undergo Robot-assisted Radical Prostatectomy With Planned Unilateral or Bilateral Nerve-sparing Surgery
Neurovascular Bundle Stimulation During Robot-Assisted Radical Prostatectomy
This prospective first-in-human feasibility study will evaluate the safety and feasibility of selective electrical stimulation of the neurovascular bundles (NVBs) during nerve-sparing robot-assisted radical prostatectomy (RARP).
- Trial name
- NVB Stym-RARP (NCT07724028)
- Testing
- Selective Neurovascular Bundle Stimulation Probe
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Coagulation Protein Disorders, Blood Loss, Surgical
Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Study)
Beriplex® P/N is made from human plasma (the liquid part of the blood) and contains the coagulation factors II, VII, IX and X which are important for blood clotting (coagulation).
- Conditions
- Coagulation Protein Disorders, Blood Loss, Surgical, Perioperative Care
- Trial name
- NCT01053169
- Testing
- Beriplex® P/N, Fresh Frozen Plasma (FFP) and Beriplex® P/N, Fresh Frozen Plasma
- Where
- 6 sites in United Kingdom
- Volunteers
- 445 people
- Sponsor
- CSL Behring