Clinical trials: Intraoperative Complication, open to volunteers
Esophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)
Effect of VExUS Score on Postoperative Pulmonary Complications in Elderly Patients
Brief Summary This clinical trial aims to evaluate whether perioperative goal-directed fluid therapy (GDFT) targeting a venous excess ultrasound (VExUS) score of 1 can reduce postoperative pulmonary complications (PPCs) in…
- Trial name
- NCT07691944
- Testing
- VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
- Volunteers
- 126 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Pulmonary Nodule, Pneumothorax
Safety And Recovery Of Tubeless Strategy In Uniportal VATS Wedge Resection
Brief Summary The goal of this clinical trial is to evaluate the safety and recovery outcomes of different tubeless strategies in adult patients undergoing uniportal video-assisted thoracoscopic (VATS) wedge resection who are…
- Conditions
- Pulmonary Nodule, Pneumothorax, Postoperative Complications
- Trial name
- NCT07395349
- Testing
- Conventional Chest Tube Drainage, Single Intraoperative Aspiration Tubeless, Double Intraoperative Aspiration Tubeless
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Obstructive Jaundice, Pancreatic Head Cancer
Impact of Intraoperative PTCD Catheter Retention Versus Removal on Postoperative Short-term Outcomes After Pancreaticoduodenectomy in Obstructive Jaundice
Pancreaticoduodenectomy (PD) is a complex surgical procedure commonly performed for tumors of the pancreatic head and periampullary region.
- Conditions
- Obstructive Jaundice, Pancreatic Head Cancer, Periampullary Neoplasms, Biliary Tract Neoplasms
- Trial name
- NCT07532759
- Testing
- PTCD Catheter Removal, PTCD Catheter Retention
- Volunteers
- 100 people
- Sponsor
- Xu'an Wang
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Surgical Site Infection
Povidone-iodine vs Saline Solution in Colorectal Surgeries and Its Effects on the Surgical Site Infection
Considering the relatively high incidence of surgical site infection (SSI) in colorectal surgery, this trial will compare rates of SSI in patients undergoing colorectal resections followed by surgical wound irrigation with…
- Trial name
- NCT06302335
- Testing
- Povidone-iodine, Saline solution
- Where
- Brazil
- Volunteers
- 228 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hemorrhage, Surgical, Tonsillar Bleeding
TEAPOT Study Multisite
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT07565753)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Leiomyoma, Uterine, Benign Gynecological Disease
Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy
vNOTES (vaginal natural orifice transluminal endoscopic surgery) hysterectomy is performed entirely through the vagina, with no abdominal incision.
- Conditions
- Leiomyoma, Uterine, Benign Gynecological Disease, Abnormal Uterine Bleeding (AUB), Uterine Prolapse
- Trial name
- vNOTES_NMBDIET (NCT07730970)
- Testing
- Deep Neuromuscular Blockade (NMB), Standard (moderate) neuromuscular blockade, Preoperative low-residue diet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Obesity, Bariatric Surgery
Indocyanine Green Fluorescence Angiography (ICG-FA) in Revisional Bariatric Surgery
This study will compare different doses of a green fluorescent product that is administered during weight loss surgery in order to observe where blood vessels are located.
- Trial name
- BariGreen (NCT07000539)
- Testing
- Indocyanine Green Angiogram
- Where
- Mexico
- Volunteers
- 108 people
- Sponsor
- Instituto Mexicano del Seguro Social
Remimazolam, Propofol
Remimazolam on the Incidence of Postoperative Acute Kidney Injury
We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the…
- Conditions
- Remimazolam, Propofol, Acute Kidney Injury, Hemodynamic Stability
- Trial name
- NCT07674719
- Testing
- Remimazolam (Byfavo), propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Seoul National University Bundang Hospital
Blood Loss, Surgical, Postoperative Hemorrhage
Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery.
The goal of this clinical trial is to learn whether the Hemorai Vysio wearable device can be used safely and feasibly to track relative changes over time in tissue oxygen, hemoglobin-related signals, blood flow, and oxygen use…
- Trial name
- VYSIO-FEASIBIL (NCT07826637)
- Testing
- Wearable optical hemodynamic monitoring device
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hemorai Inc
Breast Reconstruction, Perfusion; Complications
Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Recon
The purpose of the study is to determine whether pharmacologic delay using minoxidil in patients undergoing bilateral risk reducing mastectomy with reconstruction could achieve improvement in flap perfusion and flap viability at…
- Conditions
- Breast Reconstruction, Perfusion; Complications, High Risk for Breast Cancer, Genetic Predisposition
- Trial name
- NCT07264790
- Testing
- Minoxidil, Hair mousse
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
General Anesthesia, Intraoperative Monitoring
Analysis of Breath Sounds During Surgery
This study aims to analyze breath sounds during surgery by using electronic stethoscope sensors attached to patients under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Monitoring, Respiratory Sounds
- Trial name
- BREATHSOUND (NCT07280546)
- Testing
- Electronic stethoscope monitoring
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Endometriosis, Endometriosis-related Pain
Intraoperative Sono-assessment In Deep Endometriosis
Deep infiltrating endometriosis (DIE) involving the bowel, particularly the rectosigmoid region, is associated with significant gastrointestinal symptoms and impaired quality of life.
- Conditions
- Endometriosis, Endometriosis-related Pain, Pelvic Pain Syndrome, Endometriosis, Rectum
- Trial name
- INSIDE (NCT07517081)
- Volunteers
- 57 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Postoperative Delirium (POD), Gynecologic Cancers
Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic Oncology
Early postoperative delirium (POD) is a common and distressing neuropsychiatric complication frequently observed in elderly patients undergoing major surgical interventions, including radical and cytoreductive gynecologic…
- Conditions
- Postoperative Delirium (POD), Gynecologic Cancers, Malnutitrion
- Trial name
- NCT07877285
- Testing
- Preoperative Immunonutritional Scoring and Intraoperative Neuromonitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Cancer Surgery, Intraoperative Hypothermia
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor.
- Conditions
- Cancer Surgery, Intraoperative Hypothermia, Targeted Temperature Management, Postoperative Delirium
- Trial name
- NCT06256354
- Testing
- Routine thermal management, Target temperature management
- Where
- 36 sites in China
- Volunteers
- 3,992 people
- Sponsor
- Peking University First Hospital
Intraoperative Pain, Postoperative Pain
PECS-II vs ESP in Nociception Level Index Guided Breast Surgery
Background: Breast surgery is often associated with significant perioperative pain. While systemic opioids are commonly used, their side effects (nausea, vomiting, respiratory depression, delayed recovery) have encouraged the…
- Trial name
- NOL (NCT07002541)
- Testing
- PECS II block, ESP block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Intraoperative Bleeding
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of…
- Trial name
- NCT06427707
- Testing
- Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University