Clinical trials: Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome, Cataract
Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome (IFIS) is a potentially serious cataract surgery complication. IFIS is most commonly associated with the chronic use of tamsulosin and other alpha1-adrenergic receptor antagonists prescribed in…
- Conditions
- Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT06266962
- Testing
- 1% Atropine drops, Epinephrine
- Where
- Czechia
- Volunteers
- 164 people
- Sponsor
- University Hospital Olomouc
Intraoperative Floppy Iris Syndrome
Retrobulbar Injection of Anesthesia Versus Healon 5 in the Management of Intraoperative Floppy Iris Syndrome
In this study, the investigators plan to compare the incidence and complications of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients taking tamsulosin (Flomax) and treated with retrobulbar injection…
- Trial name
- NCT00627913
- Testing
- Healon 5 injection, Retrobulbar anesthetic injection
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Penn State University
Intraocular Lens Replacement, Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome Undergoing Intraocular Lens Replacement Surgery
The purpose of this study is to evaluate the effect of OMS302 on the signs of Intraoperative Floppy Iris Syndrome in patients at risk.
- Trial name
- NCT02093689
- Testing
- Part 1 OMS302, Part 2 OMS302
- Where
- 2 sites in Austria, Germany
- Volunteers
- 18 people
- Sponsor
- Omeros Corporation
Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome in Women
Cataract surgery is one of the most commonly performed surgical procedures worldwide. During this surgery, the pupil needs to be adequately widened (dilated) to allow the surgeon to safely access and remove the clouded lens.
- Trial name
- NCT07687407
- Where
- Turkey (Türkiye)
- Volunteers
- 704 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Intraoperative Floppy Iris Syndrome
The Effect of Anterior Corneal Incisions on Intraoperative Floppy Iris Syndrome (IFIS) Incidence and Severity in Tamsulosin Treated Cataract Patients
Intraoperative Floppy Iris Syndrome (IFIS) may occur during cataract surgeries in patients treated with alpha 1 blockers. IFIS related to alpha 1 blocker Tamsulosin (used for prostate hypertrophy) was reported in 50-90% of…
- Trial name
- NCT01070602
- Testing
- anterior (more central) corneal paracentesis incision
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Meir Medical Center
Intraoperative Floppy Iris Syndrome
Pupil Dilation for Treatment of IFIS
A novel intervention for targeting the treatment of Intraoperative Floppy Iris Syndrome.
- Trial name
- NCT03760185
- Testing
- Brimonidine Tartrate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Denver Health and Hospital Authority
Management of Intraoperative Floppy-iris Syndrome and Small Pupils With Different Mechanical Devices
Methods to Manage Intra-operative Floppy-iris Syndrome and Poor Pupil Dilation in Cataract Surgery
Cataract surgery is one of the most frequently performed surgeries worldwide and complications are rare. However, there are factors that increase the risk of complications, such as poor pupil dilation and intra-operative floppy…
- Trial name
- IFIS (NCT01778959)
- Testing
- Malyugin Ring, Iris hooks, standard OVD
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome in Korean Patients Taking α1-Adrenergic Receptor Antagonists
Intraoperative floppy iris syndrome (IFIS) is a recently described condition observed during cataract surgery. It has been hypothesized that irreversible atrophy of the iris dilator muscle associated with α1-adrenergic receptor…
- Trial name
- NCT01704014
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Floppy Iris Syndrome
Flomax Study for Floppy Iris Syndrome
Some men who have a history of use of Tamsulosin (Flomax) are at risk for a condition called Intraoperative Floppy Iris Syndrome that can develop during otherwise routine cataract surgery.
- Trial name
- NCT01252472
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Miosis Disorder, Intraoperative Floppy Iris Syndrome
Use of APX 100 Device for Small-pupil Cataract Surgery and Intraoperative Floppy-iris Syndrome
The purpose of the study is to gather clinical data and safety information on the use of APX 100 device for small-pupil cataract surgery and the management of intraoperative floppy iris syndrome (IFIS) during cataract surgery.
- Trial name
- NCT01693575
- Testing
- Pupil expansion with APX 100 device
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Meir Medical Center
Intraoperative Floppy Iris Syndrome, Cataract
Pupillary Dilator Muscle Thickness as a Potential Predictor of Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome (IFIS) is a potencial complication encountered during cataract surgery in patients treated with α1-adrenergic receptor antagonists (α1-ARAs) for lower urinary tract symptoms.
- Conditions
- Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT07517094
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Olomouc
Benign Prostatic Hyperplasia, Tamsulosin
Iris Structural Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients
Inhibition of alpha-1 adrenergic receptors by drugs such as tamsulosin and silodosin, which are prescribed for the treatment of benign prostatic hyperplasia, can lead to intraoperative floppy iris syndrome (IFIS) during cataract…
- Conditions
- Benign Prostatic Hyperplasia, Tamsulosin, Silodosin, Intraoperative Floppy Iris Syndrome
- Trial name
- NCT07743034
- Testing
- tamsulosin 0.4mg, Silodosin 8 mg
- Volunteers
- 40 people
- Sponsor
- Mohsen Pourazizi
Cataract, Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome
An assessment of the surgical performance of DisCoVisc compared to Healon5 during cataract surgery with intraocular lens implantation where miotic/small pupils or intraoperative Floppy Iris Syndrome exists.
- Trial name
- NCT00711347
- Testing
- DisCoVisc, Healon5
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Alcon Research