Clinical trials: Intraoperative Hypertension
Abdominal Compartment Syndrome
Intraoperative Peak Airway Pressure Changes on Postoperative Pulmonary Function After Muscle Plication
An abdominal panniculus excision procedure is known as an abdominoplasty (panniculectomy). Musculofascial plication is a crucial aspect of abdominoplasty, especially for patients with significant divarication of the recti…
- Trial name
- NCT06291389
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Atelectasis, Hypertension
Pulmonary Evaluation With Ultrasound in Different Levels of PEEP
Patients submitted to general anesthesia and artificial ventilation almost always develop pulmonary atelectasis, which can determine adverse consequences both intraoperatively and postoperatively.
- Conditions
- Atelectasis, Hypertension, Lung Edema
- Trial name
- EVALUS (NCT03211936)
- Testing
- PEEP TITRATED, Use ultrasound, Impedance tomography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Cardiac Surgery
IMMPRES: Intraoperative Monitoring & Management to Reduce Stroke
The objective of this study is to prospectively evaluate the therapeutic effectiveness of with blood pressure management using intraoperative neurophysiological monitoring with SSEP and EEG to reduce perioperative stroke.
- Trial name
- NCT04543838
- Testing
- Intervention, Standard of Care BP management
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Parthasarathy Thirumala
Optic Nerve Sheath Diameter, Intracranial Pressure Increase
Intraoperative Optic Nerve Sheath Diameter Changes After Laparoscopic Surgery
Laparoscopic surgery is a widely used alternative to open surgery; Advantages include reduced bleeding and pain intensity, shorter hospital stay, and improved cosmetic results.
- Trial name
- NCT06209034
- Testing
- Optic nerve sheath measurement
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Kocaeli University
Tourniquet Hypertension
A Long Axis Approach to the Femoral Artery Block (FAB) for Managing Tourniquet Pain and Hypertension in Below-the-Knee Fracture Surgery
This is a prospective, randomized, double-blind controlled trial evaluating an ultrasound-guided femoral artery block (FAB) using a long-axis in-plane approach compared with a short-axis approach and a control group.
- Trial name
- FAB (NCT07548567)
- Testing
- Femoral artery block - short-axis, Femoral artery block - long-axis, Normal saline injection (control)
- Where
- Greece
- Volunteers
- 84 people
- Sponsor
- National and Kapodistrian University of Athens
Glaucoma, Glaucoma Following Surgery
Anterior-segment OCT (AS-OCT) and Intraoperative OCT (iOCT) for Trans- Conjunctival Needle Revision (TCNR)
Trabeculectomy is a very important and commonly performed glaucoma operation. It allows fluid from inside the eye to exit into a space called a bleb located on the surface of the eye under the upper eyelid.
- Trial name
- NCT05790408
- Testing
- Digital microscope integrated with intraoperative OCT (Zeiss Artevo 800, Carl Zeiss Meditec AG), Spectralis Anterior-segment OCT (AS-OCT) (Heidelberg Engineering)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Epiretinal Membrane, Glaucoma
Efficiency of Intraoperative Optical Coherence Tomography (iOCT)
Efficiency of Intraoperative Optical Coherence Tomography (iOCT) Hypothesis: The use of iOCT during surgery offers the advantage of a new view of the operating field, theoretically allows more precise performance and can also…
- Conditions
- Epiretinal Membrane, Glaucoma, Cornea
- Trial name
- NCT05232539
- Testing
- Intraoperative Optical Coherence Tomography (iOCT)
- Where
- Czechia
- Volunteers
- 2 people
- Sponsor
- Somich, s.r.o.
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Intraabdominal Hypertension, Prone Postion
Changes of Intra Abdominal Pressure During Surgeries in Prone Position as a Marker of Renal Damage
Background: Patients undergoing surgical operations in prone position do not have a measure of intra abdominal pressure as a standard procedure.
- Conditions
- Intraabdominal Hypertension, Prone Postion, Spine Surgery
- Trial name
- NCT05626868
- Testing
- Intra abdominal pressure measurement
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- Medical University of Warsaw
Intracranial Pressure Increase
Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD)
The placement of external ventricular drainage (EVD) is a life-saving procedure used to relieve high pressures in the brain. Often performed at the bedside, a small tube (catheter) is inserted into one ventricle of the brain to…
- Trial name
- NCT05931991
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sodium Lactate, Intracranial Hypertension
Sodium Lactate and Brain Relaxation (LSD)
Resection surgery of brain tumors by craniotomy requires efficient brain relaxation intraoperatively in order to avoid injuries caused by the brain retractors (such as ischemic-reperfusion and cerebral oedema).
- Conditions
- Sodium Lactate, Intracranial Hypertension, Brain Relaxation
- Trial name
- LSD (NCT04488874)
- Testing
- Sodium Lactate, Mannitol 20% Infusion
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hypertension, Hypotension
Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure
The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic basis, causes more intraoperative…
- Conditions
- Hypertension, Hypotension, Edema, Congestive Heart Failure
- Trial name
- NCT00115726
- Testing
- furosemide
- Where
- 3 sites in United States, Canada
- Volunteers
- 198 people
- Sponsor
- University of Calgary
Obesity, Sleep Apnea
Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing…
- Conditions
- Obesity, Sleep Apnea, Diabetes, Hypertension
- Trial name
- NCT02213159
- Testing
- Dexmedetomidine, Morphine
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- American University of Beirut Medical Center
Cognitive Performance, Hypertension
Intraoperative Blood Pressure and Cognitive Performance
The purpose of this study is to prospectively determine the association between incidence of neurological morbidity and minimum fractional blood pressure reached during laminectomy procedures under general anesthesia in…
- Trial name
- NCT00827385
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Glaucoma
Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin C
A clinical trial to establish the long term response of using intraoperative 5-fluorouracil (5-FU) versus mitomycin C (MMC) in trabeculectomy glaucoma surgery.
- Trial name
- NCT00346489
- Testing
- 5-fluorouracil, Mitomycin C
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Indiana University
Hypertension
Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension
This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.
- Trial name
- NCT04953156
- Testing
- Nitroglycerin, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- National Cancer Institute, Egypt
Glaucoma, Primary Open Angle Glaucoma
Intraoperative 5-fluorouracil Augmentation of Trabeculectomy
5-fluorouracil (5FU) is an antimetabolite that has been demonstrated to have beneficial effects when injected into the subconjunctival space after glaucoma surgery (trabeculectomy).
- Trial name
- MoreFlow (NCT06745856)
- Testing
- 5-fluorouracil
- Volunteers
- 368 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Liver Transplantation, Portal Hypertension
Portal Pressure Effects of Phlebotomy Combined to Vasopressin Use in Cirrhotic Patients Undergoing Liver Transplantation
Liver transplantation is the standard treatment for chronic advanced liver disease, whether or not associated with a primary liver tumor.
- Conditions
- Liver Transplantation, Portal Hypertension, Blood Transfusion, Blood Loss, Surgical
- Trial name
- PORTAL (NCT04472312)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Tourniquet Hypertension
Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery
Knee pain is very common, and more people are having minor knee surgeries done through a small camera (arthroscopy), often as outpatients.
- Trial name
- torniquet (NCT06936410)
- Testing
- Lidocaine 2% Injectable Solution, Dexmedetomidine HCL Injection
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Cairo University