Clinical trials: Intraoperative Injury
Acute Kidney Injury
Association of Intraoperative Haemodynamic and Postoperative Complications in Type A Aortic Dissection Surgery
Background To determine whether venous congestion is an important predictor of postoperative kidney injury and other adverse events after type A aortic dissection (TAAD).
- Trial name
- NCT06440161
- Testing
- Primary exposures were venous congestion defined by central venous pressure (CVP) and mean arterial pressure (MAP).
- Where
- China
- Volunteers
- 543 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Ankle Injuries
Intraoperative Three Dimensional Fluoroscopy Compared to Standard Fluoroscopy for the Assessment of Reduction of Ankle Fractures With Syndesmosis Disruption
Ankle fractures are common injuries that are being operated routinely. In order to restore the long term function and prevent arthritis of the ankle the broken fragments should be put in place precisely.
- Trial name
- NCT00556010
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Transplantation, Hepatectomy
Effect of Intraoperative Music on Inflammatory Response in Donor Hepatectomy
It has been reported that non-pharmacological methods can be used as an alternative in addition to pharmacological methods to reduce pain, anxiety, stress and inflammatory response that begins with the surgical incision in the…
- Conditions
- Transplantation, Hepatectomy, Music, Stress Response
- Trial name
- NCT06166186
- Testing
- music, no music
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Istinye University
Ischemic Reperfusion Injury
Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion
As a simple auxiliary tool for lower extremity orthopedic surgery, tourniquet can effectively reduce intraoperative bleeding and ensure the clarity of the operative field, effectively shorten the operation time and improve the…
- Trial name
- NCT05661227
- Testing
- Dexmedetomidine, 0.9% Sodium chloride, Tourniquet(Early)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Hebei Medical University Third Hospital
Liver Transplantation, Surgical Site Infection
Surgical Site Infections After Liver Transplantation Based on Perioperative Antibiotics
This study will be to prospectively determine differences in Surgical Site Infection (SSI) if a prolonged course of post-operative antibiotics are used following liver transplantation.
- Trial name
- NCT02717273
- Testing
- standard, extended, liver transplant
- Volunteers
- 102 people
- Sponsor
- University of Virginia
Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS)
Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS)
The objective of this study is to compare the effects of two intraoperative fluid regimens - restrictive versus liberal (standard)- on postoperative outcomes (e.g.
- Conditions
- Acute Lung Injury (ALI), Acure Respiratory Distress Syndrome (ARDS), Sepsis
- Trial name
- NCT00854386
- Testing
- liberal fluid administration, restrictive fluid administration
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tidel Volume Challenge Test
T.V Challenge to Predict Early Post- Operative Acute Kidney Injury and Intra-operative Hypotension in Laparoscopic Abdominal Surgeries
The purpose of study is to verify the predictability of TV Chalange test during laparoscopic abdominal surgery for early postoperative AKI and intra-operative hypotension. .
- Trial name
- NCT05301582
- Testing
- Tidal volume challenge test
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Acute Kidney Injury, Frailty
The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP
The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients.
- Trial name
- NCT07030179
- Testing
- Frailty status
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Lanyue Zhu
Incidence of Surgical Site Infection, Short Intraoperative Briefings
Impact of Structured Communication in the OR on Surgical Site Infections: Prospective Observational Clinical Trial
Surgical site infection (SSI) is the most frequent complication in patients that undergo abdominal surgery. A previous prospective observational study in 167 patients undergoing elective open abdominal procedures showed that…
- Conditions
- Incidence of Surgical Site Infection, Short Intraoperative Briefings, Mortality, Shared Mental Model
- Trial name
- StOP (NCT02428179)
- Testing
- StOP? - Control group, StOP? - Intervention group
- Where
- Switzerland
- Volunteers
- 3,003 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intraoperative Hypotension
Hypotension Prediction Index and Intraoperative Hypotension Incidence
This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery.
- Trial name
- NCT06909786
- Testing
- HPI guided hemodynamic management, standard arterial line
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cardiac Surgery
Individualized Blood Pressure Management in Patients Undergoing Cardiac Surgery
This pilot randomized-controlled study will determine the feasibility of large study comparing individualized versus standard blood pressure (BP) management in patients undergoing cardiac surgery under cardiopulmonary bypass…
- Trial name
- PRECISE (NCT03784690)
- Testing
- Individualized intraoperative BP management, Standard intraoperative BP management
- Where
- Russia
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Kidney Injury
Preoperative Serum Albumin and Duration of Intraoperative Hypotension on Postoperative Acute Kidney Injury
Acute kidney injury is one of major adverse postoperative complications. research about postoperative acute kidney injury conclude that low preoperative albumin and intraoperative hypotension is associated to postoperative acute…
- Trial name
- NCT03882658
- Where
- China
- Volunteers
- 37,610 people
- Sponsor
- Peking University First Hospital
Pressure Injury
Decreasing Intraoperative Skin Damage in Prone Position Surgeries
Preventing Pressure Injuries among patients undergoing spinal or orthopedic surgery in the prone position is challenging because of position required for surgical access and limited availability of pressure reduction surfaces for…
- Trial name
- P3I (NCT04884737)
- Testing
- Mepilex Border Flex® (MBF) dressing
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of California, Los Angeles
Intraoperative Arterial Hypotension
Association of Intraoperative Blood Pressure Excursions Below Cerebral Autoregulatory Boundaries With Organ Injury Following Major Noncardiac Surgery
The aim of study is to investigate the clinical relevance of blood pressure (BP) excursions below cerebral autoregulatory boundaries in major noncardiac surgery.
- Trial name
- AR-NONCARDIAC (NCT05336864)
- Testing
- Non-invasive cerebral oximetry monitoring, additional perioperative blood sampling, clinical & telephone assessments
- Where
- 3 sites in Switzerland
- Volunteers
- 650 people
- Sponsor
- University Hospital, Basel, Switzerland
Patella Fracture
Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation
The objective of this study is to demonstrate the safety and efficacy of an intra-articular analgesics cocktail injection for post-operative patella fracture fixation patients, by comparing post-operative pain relief and…
- Trial name
- NCT07006168
- Testing
- Ketorolac 15mg, Triamcinolone Acetonide 40mg, Ropivacaine HCL 1% 15ml
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- The University of Hong Kong
Intraoperative Pain, Postoperative Pain
Truncal Blocks Versus Wound Infiltration for SICD
This is a single-center, randomized and prospective trial of all patients undergoing S-ICD implantation. Subjects will only be eligible for this study if they are ≥ 18 years of age and eligible to undergo S-ICD implant at Mount…
- Trial name
- NCT04974762
- Testing
- Wound infiltration, Truncal blocks
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Scars
The Effects of Fractional Carbon Dioxide (CO2) Laser Treatment Prior to Wound Closure
The purpose of this study is to determine if fractional carbon dioxide laser treatment of a fresh wound at the time of surgery, decreases scar formation. Scar revision is commonly done at 6-10 weeks following surgery.
- Trial name
- NCT00969475
- Testing
- Lumenis fractional carbon dioxide laser
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Moy-Fincher Medical Group
Burns
Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients
The purpose of this study is to determine whether a low-dose ketamine infusion can be used as the main intra-operative analgesic in different burn patients, and thereby reduce the total intra-operative opioid requirement.
- Trial name
- NCT03049930
- Testing
- Ketamine, Sodium chloride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Loyola University
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis
Spinal Cord Associative Plasticity Study
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
- Trial name
- SCAP (NCT05163639)
- Testing
- Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Benign Multinodular Goiter, Thyroidectomy
Intraoperative Methylene Blue Spray for the Identification and Preservation of Vital Structures in Thyroidectomy
This randomized controlled trial aims to evaluate the efficacy of intraoperative methylene blue (MB) spray in improving the identification and preservation of the recurrent laryngeal nerve (RLN) and parathyroid glands (PGs)…
- Conditions
- Benign Multinodular Goiter, Thyroidectomy, Recurrent Laryngeal Nerve Injury, Hypoparathyroidism
- Trial name
- NCT07395388
- Testing
- Intraoperative topical methylene blue spray, Conventional Dissection
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Services Hospital, Lahore