Clinical trials: Intraoperative Injury
Fracture Neck of Femur
Internal Fixation of Hip Fractures Using Intraoperative Simultaneous Two Axis View
Hip fractures are one of the most frequent operated fractures procedures in orthopedics, with a world wide annual incidence of approximately 1.7 million. These fractures are associated with substantial morbidity and mortality.
- Trial name
- NCT01524718
- Testing
- Imaging with two X-ray image intensifiers
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Ischemic Reperfusion Injury
Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion
As a simple auxiliary tool for lower extremity orthopedic surgery, tourniquet can effectively reduce intraoperative bleeding and ensure the clarity of the operative field, effectively shorten the operation time and improve the…
- Trial name
- NCT05661227
- Testing
- Dexmedetomidine, 0.9% Sodium chloride, Tourniquet(Early)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Hebei Medical University Third Hospital
Adverse Effect of Radiation Therapy
IORT-Boost-Study, Prospective Observational Study for Intraoperative Radiotherapy of the Breast as a Boost
In this study the investigators observe the investigation, whether the new method for Boost-Irradiation with the Intrabeam Device of Zeiss Germany influences local recurrence, acute and late effects of Radiotherapy, overall…
- Trial name
- NCT02114086
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- Kantonsspital Münsterlingen
Cataract, Surgical Injury
Eye Surface Properties After Using Dexamethasone Drops With and Without Preservatives in Patients After Cataract Surgery
The goal of this interventional, real world data study is to evaluate the impact of preservatives on the post-cataract ocular surface. The main question is to learn about an effect of preservatives on the eye surface.
- Conditions
- Cataract, Surgical Injury, Healing Wound
- Trial name
- EyeSurface (NCT05753787)
- Testing
- preservative-free solution of standard post-cataract eye drops
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Spektrum Center of Clinical Ophthalmology
Surgical Injury, Back Pain Lower Back Chronic
Spinal Approach for Lumbar Active Discopathy
The study aims to study the impact on different surgical approaches for lumbar active discopathy. This inflammatory disease of the disc and adjacent vertebral endplates can induce low back pain with inflammatory-like features.
- Trial name
- NCT04086199
- Testing
- Lumbar discectomy
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Pneumocephalus
Ventilation With High Oxygen Content and Postoperative Pneumocephalus
The aim of this study is to compare the incidence and volume of postoperative pneumocephalus in patients receiving ventilation with 100% oxygen during the last stage of surgery versus a conventional 1:1 oxygen/air gas mixture.
- Trial name
- NCT02722928
- Testing
- Controlled Ventilation with 100% oxygen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Blood Pressure, Dexmedetomidine
Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes
Perioperative organ injuriy remain an important threat to patients undergoing major surgeries. Intraoperative hypotension is associated with an increase in postoperative morbidity and mortality.
- Conditions
- Blood Pressure, Dexmedetomidine, High-risk Patients, Abdominal Surgery
- Trial name
- NCT03933306
- Testing
- Dexmedetomidine, Goal-directed blood pressure management, Routine blood pressure management
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Peking University First Hospital
Extremity Lower Wounds
Wound Necrosis in Lower Extremity Surgery
Researchers are performing this study to evaluate if intraoperative angiography can be shown numerically to determine which wounds are at high risk of wound necrosis/breakdown.
- Trial name
- NCT03351387
- Testing
- SPY Intra-operative Angiography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Malignant Tumor
Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury
To investigate the renal protective effect of dexmedetomidine in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy
- Trial name
- NCT02641938
- Testing
- Dexmedetomidine, Normal Saline
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Gangnam Severance Hospital
Surgical Site Infection, Bleeding
Mild Hypothermia Influence on Patient Outcome in Major Abdominal Surgery
This study investigate associations between mild hypothermia (patients' core temperature ≤ 36.0 degrees Celsius) and intra-operative blood loss and surgical site infections (SSI) in patients undergoing major abdominal surgery.
- Trial name
- NCT03112317
- Testing
- Prevention of hypothermia
- Where
- 2 sites in Norway
- Volunteers
- 3,059 people
- Sponsor
- Haukeland University Hospital
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cataract
Impact of a Corneal Pre-cut on Wound Architecture and Astigmatism in Cataract Surgery - a Pilot Study
We would like to evaluate the use of a 600μm pre-cut regarding wound architecture and surgically induced astigmatism as compared to a stab-incision (a corneal incision without a pre-cut).
- Trial name
- NCT02155270
- Testing
- Corneal precut 600µm, Corneal stabincision
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Thyroid Disease, Recurrent Laryngeal Nerve Injury
Low-Current Stimulation for Recurrent Laryngeal Nerve Protection During Thyroid Surgery
This single-center prospective randomized interventional study evaluated whether intraoperative low-current stimulation could assist recurrent laryngeal nerve localization and reduce temporary recurrent laryngeal nerve injury…
- Trial name
- NCT07706699
- Testing
- 3 mA low-current stimulation-assisted recurrent laryngeal nerve identification, 5 mA low-current stimulation-assisted recurrent laryngeal nerve identification
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Intraoperative Ureter Injury
Open-label Study to Evaluate Nerindocianine as a Surgical Aid in Ureter Delineation During Minimally Invasive Surgery
Phase 2, multicenter, efficacy and safety study evaluating the use of nerindocianine for the delineation of abdominopelvic ureter anatomy via near infrared fluorescence imaging during minimally invasive lower abdominal surgery…
- Trial name
- NCT04636567
- Testing
- Nerindocianine for injection
- Where
- 2 sites in United States
- Sponsor
- Li-Cor, Inc.
Chronic Subdural Hematomas
Middle Meningeal Artery Coagulation During Burr-Hole Drainage for Chronic Subdural Haematoma (BURR-MMA)
Chronic subdural haematoma (cSDH) is a common condition in older adults, usually treated by burr-hole surgery to drain the collection.
- Trial name
- BURR-MMA (NCT07549893)
- Testing
- CT-Guided Intra-Operative Middle Meningeal Artery Interruption
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Femoral Neck Fractures
Intraoperative Monitoring of Femoral Head Perfusion
An ICP monitor will be used to record blood flow/perfusion of the femoral head following fixation of femoral neck fractures. FDA approved device but not for this use.
- Trial name
- NCT04110639
- Testing
- Intracranial pressure (ICP) monitor, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Healthcare of Atlanta
Graft Failure
Intraoperative NIRS of Transplanted Kidney for Prediction of Acute and Sub-acute Injury
This is a prospective, observational cohort study, designed to explore the use of NIRS in kidney transplants. This study will investigate an association between measurements of intra- operative NIRS and post - operative graft…
- Trial name
- NCT04685174
- Testing
- Invos Model 5100C Cerebral/Somatic Oximeter
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hip Pain Chronic, Hip Impingement Syndrome
Tranexamic Acid (TXA) in Hip Arthroscopy
The primary goal of this study will be to determine if perioperative IV Tranexamic Acid (TXA) administration will reduce intra-operative bleeding and subsequently improve visual clarity during surgery and reduce operative…
- Conditions
- Hip Pain Chronic, Hip Impingement Syndrome, Hip Injuries, Blood Loss
- Trial name
- NCT05710146
- Testing
- Tranexamic acid
- Where
- United States
- Sponsor
- Northwestern University
Acute Renal Failure
Development and Validation of an Enhanced Prediction Score for Postoperative Acute Renal Failure After Liver Resection
Post-operative acute renal failure is a severe post-operative complication and is associated with high mortality. The enhanced prediction score, including pre-as well as intra-operative predictors accurately predicted ARF…
- Trial name
- NCT01318798
- Where
- Switzerland
- Volunteers
- 549 people
- Sponsor
- University of Zurich