Clinical trials: Intraoperative Injury
Cholecystectomy, Laparoscopic
Smart Intraoperative Reminder to Implement Safety Principles in Laparoscopic Cholecystectomy
The Critical View of Safety (CVS) is universally recommended to prevent bile duct injuries in laparoscopic cholecystectomy. However, CVS is underutilized and bile duct injuries are not decreasing.
- Trial name
- CVS-Notifier (NCT06895200)
- Testing
- CVS-Notifier SaMD
- Where
- France
- Volunteers
- 40 people
- Sponsor
- IHU Strasbourg
Spine Infection
Effectiveness of Povidone-Iodine Versus Chlorhexidine Gluconate Solutions in Reducing Microbial Contamination in Spinal Surgery Wounds During Intraoperative Soaking.
This study aims to assess the efficacy of intraoperative wound irrigation with iodine-containing and chlorhexidine-containing solutions in reducing bacterial colonization during spine surgery, and to determine which solution is…
- Trial name
- NCT06284174
- Testing
- Povidone-iodine solution; chlorhexidine gluconate
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- National Cheng-Kung University Hospital
Pressure Injury
Decreasing Intraoperative Skin Damage in Prone Position Surgeries
Preventing Pressure Injuries among patients undergoing spinal or orthopedic surgery in the prone position is challenging because of position required for surgical access and limited availability of pressure reduction surfaces for…
- Trial name
- P3I (NCT04884737)
- Testing
- Mepilex Border Flex® (MBF) dressing
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of California, Los Angeles
Skin Reaction to Suture Material
Comparison Between NEOSORB Plus and NEOSORB
This study is to investigate whether NEOSORB Plus antibacterial suture (chlorhexidine diacetate coated PGLA910) is not inferior to NEOSORB suture (PGLA910) in the points of intraoperative handling.
- Trial name
- NCT02431039
- Testing
- NEOSORB PLUS, NEOSORB
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury
Effects of Intraoperative Fluid Therapy on Acute Kidney Injury After Thoracoscopic Lobectomy
Background: Acute kidney injury (AKI) often occurs after thoracoscopic lobectomy in high risk patients. Insufficient intraoperative infusion is risk factor of AKI.
- Trial name
- NCT04302467
- Testing
- fluid therapy during operation
- Where
- China
- Volunteers
- 276 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ventilator-Induced Lung Injury, Ventilator Lung
How To Prevent Ventilator-Related Lung Damage in Intraoperative Mechanical Ventilation? Pcv or Vcv ?
Introduction: Intraoperative Mechanical Ventilation practices can lead to ventilator-associated lung injury (VILI) and postoperative pulmonary complications in healthy lungs.
- Conditions
- Ventilator-Induced Lung Injury, Ventilator Lung, Mechanical Ventilation Complication, Postoperative Complications
- Trial name
- NCT05814081
- Testing
- Position/Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Surgical Site Infection, Pancreaticoduodenectomy
Association of Cephalosporin Resistance and Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy
Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many…
- Conditions
- Surgical Site Infection, Pancreaticoduodenectomy, Biliary Tract Infection Bacterial
- Trial name
- NCT05581017
- Testing
- Preoperative biliary drainage
- Where
- Finland
- Volunteers
- 376 people
- Sponsor
- Helsinki University Central Hospital
Postoperative Acute Kidney Injury, Frailty
The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP
The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients.
- Trial name
- NCT07030179
- Testing
- Frailty status
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Lanyue Zhu
Surgical Site Infection, Surgical Wound
Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies
The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients…
- Conditions
- Surgical Site Infection, Surgical Wound, Surgical Incision, Emergency Laparotomies
- Trial name
- NCT05989386
- Testing
- 0.9% saline solution, Povidone-iodine Swab
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Liver Diseases, Reperfusion Injury
Effect Inhaled Nitric Oxide in Adult Liver Transplant
Liver transplantation remains the only cure for patients with end-stage liver disease. Despite continuous advances in medical care, ischemia-reperfusion injury (IRI) (tissue damage that occurs when blood supply is restored to an…
- Conditions
- Liver Diseases, Reperfusion Injury, Vasoplegia
- Trial name
- NCT07125443
- Testing
- Prospective iNO Administration ("After" Group), No Intervention Retrospective "Before" Group
- Volunteers
- 260 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Music Therapy, Cholecystitis/Cholelithiasis
Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery
Surgery induced sterile inflammation leaves behind a biomolecular footprint measurable by various pro-inflammatory markers e.g. IL-6, CD(Cluster of differentiation)19B, HsCRP(High-sensitivity CRP) etc.
- Conditions
- Music Therapy, Cholecystitis/Cholelithiasis, Inflammatory Response, Surgical Injury
- Trial name
- NCT03429478
- Testing
- Preoperative application of a bluetooth enabled Headphones.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Sir Ganga Ram Hospital
Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery With Cardiopulmonary Bypass
Inhaled Nitric Oxide for Prevention of Postoperative AKI in High-Risk Cardiac Surgery Patients
The goal of this clinical trial is to learn if giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in patients who are at high risk of developing this complication.
- Trial name
- NCT07544147
- Testing
- Inhaled Nitric Oxide (iNO)
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Laryngeal Nerve Injuries, Thyroidectomy
Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve in Thyroid Surgery
The frequent occurrence of impaired function in the external branch of the superior laryngeal nerves following thyroid surgery is recognized as a prevalent complication leading to a diminished quality of life.
- Conditions
- Laryngeal Nerve Injuries, Thyroidectomy, Voice Change
- Trial name
- NCT06002984
- Testing
- Using Neuromonitoring to find EBSLN
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Hemodynamic Instability, Opioid Use
Effects of US-guided SAPB During Breast Surgery
The serratus anterior plan (SAP) block is a technique that has recently gained popularity in the context of breast surgery. SAP block resulted in better hemodynamic stability, early ambulation and shorter hospital stay, as well…
- Conditions
- Hemodynamic Instability, Opioid Use, Block, Breast Cancer
- Trial name
- NCT04824833
- Testing
- Serratus anterior plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Hip Fractures
Goal Directed Hemodynamic Therapy Based on Noninvasive Monitoring in Patients With Hip Fracture
Crude incidence rate in Spain of hip fracture in people over 65 years was 511 cases per 100,000 in 2002. About 30% of patients die in the first year.
- Trial name
- NCT02479321
- Testing
- GDT based on noninvasive monitoring, System ClearSight® and Platform EV Clinic 1000®
- Where
- Spain
- Volunteers
- 568 people
- Sponsor
- Juan-Víctor Lorente, MD, PhD
Orbital Fractures, Unilateral
Comparing Pre-adaptation of In-stock Mesh Over In-house 3D Patient Specific Model to Reconstruct Unilateral Primary Orbital Fracture With and Without Intraoperative Navigation vs Conventional Intraoperative Free-hand Mesh Bending
The investigators study the accuracy of repairing unilateral primary orbital fractures using a new technique, using 3D printed patient specific model to preoperative adapting of the readily available in sock titanium mesh, the…
- Conditions
- Orbital Fractures, Unilateral, Recent
- Trial name
- NCT07882121
- Testing
- 3D printed patient specific model, Conventional, Brainlab navigation system
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Myocardial Injury After Noncardiac Surgery (MINS), Hypotension During Surgery
Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury
The investigators are conducting an important study aimed at better understanding and predicting a potential complication after non-cardiac surgery: myocardial injury.
- Trial name
- NCT07094321
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- China-Japan Friendship Hospital
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Carpal Tunnel Syndrome
WALANT Versus Local Anesthesia With Tourniquet for Carpal Tunnel Decompression
This multicenter, randomized, double-blinded controlled trial compared two local anesthetic techniques for open carpal tunnel decompression in adults.
- Trial name
- WALANT vs LA-T (NCT07617064)
- Testing
- WALANT technique for carpal tunnel decompression, Local anesthesia with tourniquet for carpal tunnel decompression
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Misr University for Science and Technology