Clinical trials: Intraoperative Monitoring
Surgery, Pain
Clinical Validation of Medasense Pain Response Index (PRI)
In our previous study, NCT01631695, we proposed and clinically evaluated the Medasense pain response index, PRI, in anesthetized patients undergoing surgery. Note: the name PRI has been changed to NoL (Nociception Level) Index.
- Trial name
- NCT01762332
- Testing
- Base level of remifentanil effect side concentration: 2ng/ml, Base level of remifentanil effect side concentration: 4ng/ml, chronic beta-blocker treatment
- Where
- Israel
- Volunteers
- 82 people
- Sponsor
- Medasense Biometrics Ltd
Gynecologic Laparoscopic Surgery, Hysterectomy
Impact of Nociceptive-Level (NOL) Intraoperative Guided Analgesia During Gynecological Laparoscopic Surgery Under General Anesthesia
The aim of the present study is to show that the use of the NOL device in addition to the Standard of Care (based on mean arterial blood pressure and heart rate values) to guide the administration of opioids compared to the…
- Conditions
- Gynecologic Laparoscopic Surgery, Hysterectomy, Oophorectomy
- Trial name
- NOLGYN (NCT03776838)
- Testing
- Intravenous Fentanyl guided by SoC+NOL, Intravenous Fentanyl guided by SoC
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Elderly ; Moderate Risk Surgery
Optimized Anesthesia to Reduce Postoperative Cognitive Impairment in the Elderly
The aim of this study is to demonstrate that in elderly and frail patients, a narrower control of intraoperative blood pressure (BP) by the use of a continuous and noninvasive BP monitoring, coupled with an adequate depth of…
- Trial name
- NCT02698982
- Testing
- Depth of anesthesia monitoring (BIS, Covidien USA) and Continus non invasive blood pressure monitoring (Clearsight, Edwards LifeScience, USA), moderate risk surgery
- Where
- Belgium
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Cerebellopontine Angle Tumor
Compare the Operating Condition of Two Levels of Muscle Relaxation on Facial Nerve MEP Monitoring in CPA Surgery
compare the operating condition of two different levels of muscle relaxation on facial nerve monitoring using transcranial motor evocked potential in CPA surgery .
- Trial name
- NCT04148534
- Testing
- Rocroniom, Non Depolarizing Muscle Relaxant
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Muhammad Magdy Gaber
Spine Surgery, Pain After Surgery
Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot
The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative…
- Conditions
- Spine Surgery, Pain After Surgery, Anesthesia , Analgesia
- Trial name
- NCT07608276
- Testing
- NOL guided intraoperative analgesia
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medasense Biometrics Ltd
Parotid Gland Tumor, Facial and Neck Rhytides
Facial Nerve Monitoring During Parotid and Facial Surgery Using a Non-Invasive Patch
The goal of this study is to test if a non-invasive patch can safely monitor facial nerve activity in adults during parotid or facial surgery.
- Trial name
- NCT07523373
- Testing
- Non-invasive facial nerve monitoring patch
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Undetected Intraoperative Blood Loss
Intra-operative Monitoring of Blood Loss
Certain types of surgery are associated with occult blood loss, which is hard to detect intraoperatively by intermittent conventional, invasive Hb concentration measurements using the clinical standard of Hb monitoring by…
- Trial name
- NCT01864980
- Testing
- blood transfusion, intermittent Hbsatlab measurement, blood transfusion, based on continuous SpHb readings
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction
Distal Versus Conventional Radial Arterial Catheterization for Arterial Waveform Stability
During robot-assisted urologic surgery, both arms are often placed alongside the body and covered by surgical drapes. This position can make the arterial catheter difficult to access during surgery.
- Conditions
- Intraoperative Arterial Blood Pressure Monitoring, Arterial Catheter Dysfunction, Robotic Urologic Surgery
- Trial name
- DRA-stability (NCT07732296)
- Testing
- Conventional Radial Arterial Catheterization, Distal Radial Arterial Catheterization
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Endocrine Procedural Complications, Thyroid
Intraoperative Monitoring to Predict Postoperative Complications After Thyroidectomy
The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.
- Conditions
- Endocrine Procedural Complications, Thyroid, Parathyroid; Deficiency, Laryngeal Injury
- Trial name
- PARACAL (NCT03309384)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Central Hospital, Nancy, France
Intraoperative Hypotension, Intraoperative Complications
Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation
This study aims to compare the volume management methods performed by using conventional method and PVI monitoring in intraoperative fluid treatment during bilateral salpingo-oophorectomy and total hysterectomy operation.
- Conditions
- Intraoperative Hypotension, Intraoperative Complications, Hypervolemia, Acute Renal Failure
- Trial name
- NCT04775576
- Testing
- Pleth Variability Index, Conventional fluid theraphy, Anesthesia method
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Thyroid
Effect of Intraoperative Nerve Monitoring on Voice Quality During Thyroid Surgery
"Effect of intraoperative nerve monitoring on voice quality during thyroid surgery" Thyroidectomy is a quite often surgical procedure applied by both head and neck surgeons and endocrine surgeons.Recent advances in surgical and…
- Trial name
- NCT02509715
- Testing
- Intraoperative nerve monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Lütfiye Nuri Burat Government Hospital
Intraoperative Ureter Injury
Open-label Study to Evaluate Nerindocianine as a Surgical Aid in Ureter Delineation During Minimally Invasive Surgery
Phase 2, multicenter, efficacy and safety study evaluating the use of nerindocianine for the delineation of abdominopelvic ureter anatomy via near infrared fluorescence imaging during minimally invasive lower abdominal surgery…
- Trial name
- NCT04636567
- Testing
- Nerindocianine for injection
- Where
- 2 sites in United States
- Sponsor
- Li-Cor, Inc.
Pheochromocytoma, Paraganglioma
Prospective Cohort Study of Pheochromocytoma/Paraganglioma
The study will enroll patients scheduled for PPGL removal surgery at Peking Union Medical College Hospital. Before surgery, researchers will use a 6-variable model to predict the patient's risk of experiencing severe blood…
- Conditions
- Pheochromocytoma, Paraganglioma, Hemodynamic Instability, Intraoperative Complications
- Trial name
- NCT07516275
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Intraoperative Hemodyamic Monitoring
Arterial dP/dt Dependency on Loading Conditions
In the present study the investigators aim to assess the changes of the arterial dP/dtmax induced by fluids and vasoactive drugs during abdominal surgery
- Trial name
- REABILITY (NCT06164405)
- Testing
- arterial dp/dtmax
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Temperature Monitoring, Intraoperative
Clinical Accuracy Validation of the Moni-Patc Temperature Monitoring Patch During Surgery (Compared With Esophageal and Bladder Temperature)
Moni-Patc Temperature Monitoring Patch System, a non-invasive, continuous temperature monitoring device designed to estimate core body temperature by applying a Sensor to the neck.This clinical accuracy validation study aims to…
- Trial name
- Moni-Patch OR (NCT07397065)
- Testing
- Moni-Patc Temperature Monitoring Patch System
- Volunteers
- 30 people
- Sponsor
- Murata Vios, Inc.
Intraoperative Neurophysiological Monitoring, Pain Management
Effect of a Bolus of Clonidine Systemically Administered on the Excitability of the Spinal Motoneurons of the Lower Extremity
The purpose of this study is to assess the effect of IV clonidine administration on lower limb spinal motoneuron excitability during standardized total intravenous anesthesia (propofol and remifentanil).
- Trial name
- EXCICLON (NCT02592915)
- Testing
- Clonidine hydrochloride, Single bolus of physiologic sodium chloride serum administered IV after induction and obtaining a stable anaesthetic level
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Queen Fabiola Children's University Hospital
Brain Hypoxia Ischemia
Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM)
This study uses a CPOM Optical neuromonitor to assess the relationship between brain cytochrome C oxidase, cerebral oxygen saturation and blood pressure during surgery performed under general anesthesia.
- Trial name
- NCT03907904
- Testing
- CPOM Optical Neuromonitor
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Spine Condition
Evaluating MIONM Effectiveness in Predicting Postoperative Neurological Deficits Using Combined Modalities
Objective: This study aimed to integrate findings from spinal and cranial surgeries with existing literature, emphasizing the role of Intraoperative Neurophysiological Monitoring (IONM) in improving surgical outcomes through best…
- Trial name
- MIONM (NCT06712069)
- Testing
- Multimodal Intraoperative Neurophysiologic Monitoring (MIONM)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Intraoperative Neurophysiological Monitoring
Multi Modal Brain Monitoring and Cardiac Surgery
Multimodal brain monitoring is feasible and can be used in formulating therapeutic strategies during cardiac surgery. Such monitoring may help to improve patient outcome and to reduce costs after cardiac surgery with CPB.
- Trial name
- NCT02916069
- Testing
- Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), Bispectral index (BIS)
- Where
- Egypt
- Volunteers
- 1,200 people
- Sponsor
- Assiut University
Intraoperative Monitoring
Intraoperative Pleth Variability Index (PVI) Variability
Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively.
- Trial name
- NCT03215238
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco