Clinical trials: Intraoperative Pain Control
Post-operative Pain
Intraoperative TAP Block After Repeat Cesarean
The aim of this study is to perform a randomized trial to investigate if intraoperative surgeon administered TAP block reduces pain and use of oral and parenteral pain medications after repeat cesarean delivery.
- Trial name
- NCT05393908
- Testing
- TAP Block Group
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Postoperative Pain, Erector Spinae Plane Block in Spinal Surgery
Open Technique Erector Spinae Plane Block in Spinal Surgery
Erector spinae plane (ESP) block is an interfacial plane block with visceral and somatic analgesic activity at paraspinal muscles.ESPB has been successfully applied as a part of multimodal analgesia in treating postoperative pain…
- Trial name
- NCT06157762
- Testing
- Erector spinae plane block, Erector spinae plane block performed by surgeon
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Quality of Life
Acupuncture and Integrative Care in Gynecological Surgery
Patients undergoing surgical procedures for gynecological cancer are frequently challenged by intense anxiety prior to surgery, reflecting the accompanying uncertainty regarding the diagnosis, treatment and prognosis of their…
- Trial name
- NCT03560388
- Testing
- Acupuncture and touch/relaxation
- Where
- Israel
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Osteoarthritis, Degenerative Joint Disease
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement
The purpose of this study is to clarify the efficacy of a multidrug versus single drug periarticular injection when only standard operative and postoperative pain management protocols used and the control group is exposed to what…
- Trial name
- NCT03119038
- Testing
- Bupivicaine + epinephrine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Analgesia, Nociceptive Pain
Effect of ANI on Intraoperative Opioid Consumption
The aim of the study is to compare the analgesic nociception index (ANI), which is used to determine the dose of analgesic agent needed in the intraoperative period, with the conventional method in patients with erector spinae…
- Conditions
- Analgesia, Nociceptive Pain, Nerve Block, Pain
- Trial name
- NCT05106452
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Postoperative Pain Control, Breast Reduction
Surgeon-Guided Serratus Block in Breast Reduction Surgery
Surgeon guided serratus block, which can be performed by the surgeon in participants undergoing breast reduction surgery, may reduce the sensation of pain from the surgical field in the postoperative period.
- Trial name
- NCT06905574
- Testing
- surgeon guided serratus block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- alperen can kokten
Postoperative Analgesia
Continuous Epidural Fentanyl- Low Dose Bupivacaine Infusion Analgesia for Precious Single Kidney Patient.
Open surgical nephrectomy is associated with sever postoperative pain mandating alternative strong ,renal safety, minimal side effects, and minimal rescue systemic analgesics , continuous Epidural Fentanyl infusion in a dose step…
- Trial name
- NCT03606902
- Testing
- Group f : Epidural catheter insertion, Group F: Continous epidural infusion of bupivacaine plus fentanyl, Group LF :Continous epidural infusion of decreasing doses of fentanyl plus pubivacaine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lower Extremity Varicose Veins, Radiofrequency Ablation
Pain During Heat Treatment for Lower Extremity Varicose Veins: Radiofrequency vs. Microwave
This study compares two common heat-based procedures for treating varicose veins in the legs: radiofrequency ablation (RFA) and microwave ablation (MWA).
- Conditions
- Lower Extremity Varicose Veins, Radiofrequency Ablation, Microwave Ablation, Pain Measurement
- Trial name
- NCT07907315
- Testing
- Radiofrequency ablation, Microwave Ablation
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Chunshui He
Anesthesia
Impact of NOL Intraoperative Guided Fentanyl Analgesia vs SCC for Elective Major Abdominal Surgery
Recently, a newly developed index, the Nociceptive Level (NOL) index, was validated and showed superiority over heart rate and blood pressure for recognition and grading of intense and mild nociceptive stimuli during surgery…
- Trial name
- NCT03970291
- Testing
- PMD-200
- Where
- Israel
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Medasense Biometrics Ltd
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Anesthesia, Postoperative Pain
The Effect of Ultrasound-guided Erector Spinae Block and Intraoperative Intercostal Nerve Block on Postoperative Analgesia in Thoracic Surgery
This study aims to compare the effect of ultrasound-guided erector spinae plane block and interthoracic intercostal nerve block in thoracic surgery.
- Conditions
- Anesthesia, Postoperative Pain, Ultrasound Therapy; Complications
- Trial name
- NCT04581616
- Testing
- Intrathoracic Intercostal Nerve Block, Erector Spinae Plane Block
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Postoperative Analgesia, Intraoperative Analgesia
Comparison of Analgesic Efficacy ESP Block and QLB II in Kidney Transplantation
Renal transplantation is an increasingly common surgery in recent years. Opioid and/or NSAID use is common in postoperative pain management. However, these drugs have many side effects.
- Trial name
- NCT06660953
- Testing
- Erector Spinae Plane Block, Quadratus Lumborum Block (QLB)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Postoperative Pain, Inguinal Hernia Unilateral
Levobupivacaine and Postoperative Pain Relief
The study analysed direct levobupivacaine instillation in surgical wound and its effectiveness in postoperative pain control. Half participants received 0,5 % levobupivacaine and the other half received 0,9% saline solution
- Trial name
- NCT04869046
- Testing
- Instillation of levobupivacaine in surgical wound
- Where
- 2 sites in Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mother and Child Health Institute of Serbia Dr Vukan Cupic
Magnesium, Intraoperative Analgesia
Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy
Colonoscopy is one of the most commonly performed outpatient procedures throughout the world as a screening, diagnostic, and therapeutic tool to evaluate the large intestine from the distal rectum to the cecum.Propofol is the…
- Trial name
- NCT06131905
- Testing
- Magnesium Sulfate, Propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Analgesia
Opioid Free Anesthesia for Laparoscopic Cholecystectomy
The goal of this interventional study is to check the efficacy of Erector Spinae block as Opioid Free Anesthesia for Laparoscopic Cholecystectomy. Laparoscopic Cholecystectomy is a commonly performed day care procedure.
- Trial name
- NCT06202664
- Testing
- Erector Spinae Block, Opioid Analgesic
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Postoperative Pain
Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy
A randomized controlled trial evaluating the efficacy and safety of single-shot intraoperative methadone for postoperative pain in patients undergoing tonsillectomy. Fentanyl is used as an active comparator
- Trial name
- METATONS (NCT05445856)
- Testing
- Methadone, Fentanyl
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Postoperative Pain
Intraoperative Methadone for Postoperative Pain Control After Thoracic Surgery
Pain following surgery continues to be an important adverse outcome that may impact postoperative recovery. Opioids like fentanyl and hydromorphone are the primary medications used to provide analgesia, but paradoxically, may…
- Trial name
- NCT04525898
- Testing
- Methadone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Pain
Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious
This study aims to assess the usefulness of pupillometry as a nociceptive indicator during elective orotracheal intubation in patients given intravenous lignocaine pre-intubation as compared to a placebo pre-intubation.
- Trial name
- NCT04000126
- Testing
- Pupil reflex dilation measurement (PRD), PPI (Pupillary Pain Index), lidocaine
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury