Clinical trials: Intraoperative Use of Tranexamic Acid
Tranexamic Acid, Blood Loss, Surgical
Do Anesthesiologists Follow Guidelines on Perioperative Use of Tranexamic Acid?
Tranexamic acid has been used to reduce bleeding and transfusion for years. Randomized studies showed its efficacity in orthopedic surgery, trauma and post-partum hemorrhage.
- Conditions
- Tranexamic Acid, Blood Loss, Surgical, Blood Transfusion
- Trial name
- Periop_TXA (NCT05783648)
- Testing
- Use of tranexamic acid
- Where
- Belgium
- Volunteers
- 1,726 people
- Sponsor
- Erasme University Hospital
Breast Cancer, Blood Loss, Surgical
Role of TXA in Patients Undergoing Breast Free Flap Reconstruction
Tranexamic acid (TXA) is a synthetic, competitive lysine receptor inhibitor on plasminogen. It ultimately stabilizes the fibrin matrix, therefore used as a hemostatic agent for various indications.
- Trial name
- NCT06428682
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Osteogenesis Imperfecta
Tranexamic Acid During Telescoping Nail Application In Osteogenesis Imperfecta
The aim of this study is to assess the effective of intraoperative use of tranexamic acid in reducing blood loss during telescoping nail application in cases of osteogenesis imperfecta.
- Trial name
- NCT05321199
- Testing
- Tranexamic acid
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Intraoperative Bleeding
Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy
Exploratory tympanotomy is surgical access to the middle ear, made for diagnosis and management of unexplained conductive hearing loss, performed under an oto-microscope across the external auditory canal after tympanic membrane…
- Trial name
- NCT04188184
- Testing
- Tranexamic Acid, Epinephrine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Femoral Fractures, Hemorrhage, Surgical
Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery
This clinical study aims to evaluate the safety and effectiveness of administering a single intravenous dose of tranexamic acid (TXA) before surgery to reduce blood loss in patients undergoing open intramedullary nailing for…
- Conditions
- Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use
- Trial name
- TXA-FemNail (NCT07261930)
- Testing
- Tranexamic Acid
- Where
- Uganda
- Volunteers
- 43 people
- Sponsor
- Masaka Regional Referral Hospital
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Intraoperative Bleeding, Postoperative Edema
Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
Purpose of the study: To evaluate the effect of tranexamic acid (TXA) of intraoperative blood loss in patients subjected to bi-maxillary orthognathic surgery To evaluate the potential effect of TXA on fibrin structure To evaluate…
- Trial name
- TXA2014-15 (NCT02229292)
- Testing
- Tranexamic Acid, Saline
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Percutaneous Nephrolithotomy, Intraoperative Use of Tranexamic Acid
Tranexamic Acid in Percutaneous Nephrolithotomy
Tranexamic acid, once a randomly used antifibrinolytic agent, has been in standard protocols for many specific surgeries. Studies are still needed to standardize the dose and route of tranexamic acid administration, examine its…
- Trial name
- NCT05947435
- Testing
- Tranexamic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Blood Loss, Surgical
Use of Tranexamic Acid in Liposculpture
Blood loss during a surgical procedure is inevitable, its reduction is a key factor for surgical success. Also, to avoid progress to severe complications like hemodynamic decompensation, cardiac arrest or the need to blood…
- Trial name
- NCT04430777
- Testing
- Tranexamic acid
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Total Definer Research Group
Shoulder Joint Disease, Complications; Arthroplasty
Tranexamic Acid in Reverse Total Shoulder Arthroplasty
To the Investigators' knowledge, TXA has not been studied in the setting of reverse total shoulder arthroplasty. We propose a double-blinded, randomized, controlled trial comparing perioperative administration of TXA to placebo…
- Conditions
- Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
- Trial name
- TXA (NCT02043132)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Corewell Health East
Haemorrhage, Bariatric Surgery Candidate
the Use of Tranexamic Acid to Prevent the Bleeding in Bariatric Surgery
Our study aims at evaluating the role of tranexamic acid in bariatric surgery since, The effect of conservative therapy using tranexamic acid for postoperative hemorrhage after bariatric surgery is still very much a novel…
- Trial name
- NCT07187258
- Testing
- tranexamic acid (1 g diluted in 100 mL of 0.9% saline
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Cairo University
Intraoperative Blood Loss, Pediatric
Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy
Surgical hip reconstruction reduces the hip joint through soft tissue releases and osteotomies of the femur and/or pelvis. Blood loss and subsequent blood transfusion are normal consequences of hip reconstruction.
- Conditions
- Intraoperative Blood Loss, Pediatric, Orthopedic Disorder
- Trial name
- NCT04811313
- Testing
- Tranexamic acid, caudal epidural block
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University