Clinical trials: Intraoperative Ventilation
Postoperative Atelectasis
Effect of Intraoperative Dynamic Compliance Guided Individualized Positive End-expiratory Pressure on Postoperative Atelectasis After Laparoscopic Bariatric Surgery
This study intends to explore the effect of dynamic compliance guided individualized positive end-expiratory pressure titration strategy on reducing the level of postoperative atelectasis in obese patient who have laparoscopic…
- Trial name
- NCT04169607
- Testing
- Dynamic compliance guided individualized positive end-expiratory pressure titration strategy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuzhou Medical University
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Acute Lung Injury
A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery
The purpose of this trial is to determine whether low tidal volume during intraoperative one-lung ventilation could decrease the incidence rate of postoperative acute lung injury compared to "normal" tidal volume.
- Trial name
- NCT01194895
- Testing
- protective ventilation, conventional ventilation
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Shanghai Zhongshan Hospital
Ventilator Lung, Liver Cirrhosis
Effect of Low Tidal Ventilation on Intraoperative Bleeding in Laparoscopic Major Hepatectomy
This randomized controlled study's objective is to find a safer mechanical ventilation strategy to reduce intraoperative bleeding in liver cancer patients undergoing laparoscopic major liver resection.
- Conditions
- Ventilator Lung, Liver Cirrhosis, Hepatocellular Carcinoma, Blood Loss, Surgical
- Trial name
- NCT05490147
- Testing
- conventional tidal volume (tidal volume [ml]= ideal body weight [kg]* 10~12) group, low tidal (tidal volume [ml]= ideal body weight [kg] * 6~8) volume
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Thoracic Surgery, One-lung Ventilation
Intraoperative Neuromuscular Blockade and Postoperative Atelectasis
During one-lung ventilation in thoracic surgery, the intensity of neuromuscular blockade may change the compliance and resistance of ventilated lung, thereby affecting postoperative atelectasis.
- Trial name
- NCT03503565
- Testing
- intraoperative neuromuscular blockade
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Mechanical Ventilation Complication, Surgery
Intraoperative Hypocapnia in PROVHILO and PROBESE
To gain a better understanding of the epidemiology of intraoperative hypocapnia, in particular the associations of intraoperative hypocapnia with patient demographics, ventilator characteristics, and perioperative complications…
- Conditions
- Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative Complications
- Trial name
- iHypoPRO (NCT05550181)
- Testing
- intraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg)
- Where
- 4 sites in Brazil, Germany and 2 more
- Volunteers
- 2,793 people
- Sponsor
- NMC Specialty Hospital
ENT Tumor
Impact of the Experience of Anaesthetists in Changing Ventilation Strategies During Panendoscopy on the Incidence of Intraoperative Hypoxaemia
High Flow Nasal Oxygen Therapy (HFNO) is a new oxygenation tool that is becoming increasingly widespread in perioperative anaesthesia. The benefits of this oxygenation tool are based on different physiological principles.
- Trial name
- NCT05601570
- Where
- France
- Volunteers
- 850 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
Brain Tumor
Effect of Breathing Circuits on Intraoperative Body Temperature
To evaluate differences in intraoperative body temperature between heated huimid breathing circuit and conventional breathing circuit
- Trial name
- BT (NCT01831843)
- Testing
- Group C, Group E, Group M
- Where
- South Korea
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hypotension, Hemodynamic Instability
The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery
The "Hypotension Prediction Index (HPI)" was established by the Edwards Lifescience Company (Irvine, California, USA) and is CE certified.
- Conditions
- Hypotension, Hemodynamic Instability, Renal Failure, Myocardial Injury
- Trial name
- NCT04149314
- Testing
- HPI based hemodynamic optimization algorithm
- Where
- Germany
- Volunteers
- 142 people
- Sponsor
- University of Giessen
Intraoperative Ventilation
Arterial to End-Tidal Carbon Dioxide Difference During Pediatric Laparoscopic Surgeries
Studying the arterial to end-tidal carbon dioxide difference in children undergoing laparoscopic surgeries under different intra-abdominal pressures is of extreme importance.
- Trial name
- PaCO2-EtCO2 (NCT03361657)
- Where
- Egypt
- Volunteers
- 29 people
- Sponsor
- Assiut University
Anesthesia, Postoperative Complications
Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery
Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality.
- Conditions
- Anesthesia, Postoperative Complications, Mechanical Ventilation Complication
- Trial name
- VQppc (NCT05454917)
- Testing
- Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Università degli Studi di Ferrara
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
Ventral Hernia, Abdominal Wall Defect
Intraoperative Biomechanics in Complex Abdominal Wall Reconstruction
Background: A detailed study of the biomechanical changes before and after abdominal wall reconstruction (AWR) has not been performed.
- Trial name
- NCT03296475
- Testing
- Abdominal Wall Closure Force (N).
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College, London
Laparoscopic Renal Surgery, Laparoscopy
Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade…
- Conditions
- Laparoscopic Renal Surgery, Laparoscopy, Muscle Relaxation
- Trial name
- NCT02185339
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Seoul St. Mary's Hospital
One-Lung Ventilation
Comparison of Oxygen Saturation During Different Intraoperative Positions
One-lung ventilation (OLV) during thoracic surgery and its effect on oxygen saturation has been discussed in multiple studies. Literature shows different ventilation strategies and possible hypoxemia has been attributed to…
- Trial name
- NCT01744886
- Testing
- maintain oxygenation during one lung ventilation
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Onze Lieve Vrouw Hospital
Obstructive Sleep Apnea
Dex as Analgesic Adjuvant in OSA Patients
The purpose of this study is to assess whether intravenous peri-operative Dexmedetomidine reduces opioid requirements and or improves pain control after Uvulopalatopharyngoplasty (UPPP) in patients with obstructive sleep apnea…
- Trial name
- NCT03613558
- Testing
- Dexmedetomidine
- Where
- United States
- Sponsor
- Montefiore Medical Center
Patients Scheduled for Brain Surgery
Effect of Heated Breathing Circuit on Intraoperative Core Temperature and Systemic Inflammation After Brain Surgery: a Prospective Randomized Study
Mechanical respiration during general anesthesia causes cold and dry gases to reach the lower airway, reduce the function of the airway mucosa, and cause accumulation of secretions.
- Trial name
- NCT03491332
- Testing
- conventional circuit, conventional humidification circuit, new humidifaction heat circuit
- Where
- South Korea
- Volunteers
- 117 people
- Sponsor
- Yonsei University
Cognitive Dysfunction
The Influence of Ventilation on Perioperative Neurocognitive Disorders
This prospective study is designed to examine the influence of intra-operative ventilation on perioperative neurocognitive disorders in patients undergoing total hip arthroplasty.
- Trial name
- NCT04106869
- Testing
- Hyperventilation, Hypoventilation
- Where
- Belgium
- Sponsor
- Université Libre de Bruxelles