Clinical trials: Intrauterine Adhesion
Intrauterine Adhesion
Immediate and Delayed Intrauterine Balloon in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
In this prospective, randomized, controlled study, the investigators wish to compare the efficacy of immediate and delayed intrauterine balloon (IUB) therapy in the prevention of adhesion reformation after hysteroscopic…
- Trial name
- NCT03171454
- Testing
- Delayed Intrauterine Balloon therapy, immediate Intrauterine Balloon therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Asherman Syndrome
Establishment and Application of Endometrial 3D-organoid in Endometrial Injury Repair
Normal endometrial repair occurs without scar formation; however, in some women, these normal repair mechanisms are aberrant, resulting in intrauterine adhesion (IUA) formation.
- Trial name
- NCT05521932
- Testing
- endometrium collected
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells
Study of the treatment of infertility caused by severe intrauterine adhesions or endometrial dysplasia by collagen scaffold loaded with autologous bone marrow stem cells, and to provide clinical evidence for the treatment of…
- Conditions
- Infertility, Intrauterine Adhesions, Endometrial Dysplasia
- Trial name
- NCT02204358
- Testing
- autologous bone marrow stem cells
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Intrauterine Adhesion
Investigating the Association Between Diagnostic and Therapeutic Management Models and Prognosis of Intrauterine Adhesions Based on a Large-Scale Prospective Cohort Study
This research plan aims to explore a new diagnosis and treatment management model for intrauterine adhesions and verify its efficacy and feasibility through a multicenter real-world study.
- Trial name
- NCT07421908
- Testing
- Transcervical resection of adhesion, Uterine cavity stent, Traditional Chinese medicine for tonifying the kidney
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Intrauterine Adhesion
Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions
To observe the clinical safety of intrauterine injection of human embryonic stem cell derived mesenchymal cells in the treatment of moderate and severe intrauterine adhesion, and to preliminarily explore its clinical…
- Trial name
- NCT04232592
- Testing
- Inject a solution of stem cell preparation, Inject stem cells
- Volunteers
- 32 people
- Sponsor
- Qi Zhou
Tissue Adhesions
Safety Study of Use of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery
Operations in the uterus are currently possible using a hysteroscope. One serious though rare complication of such procedures is the development of intra-uterine adhesions. There currently are no methods to prevent this.
- Trial name
- NCT01464528
- Testing
- Hyaluronan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Intrauterine Adhesion, Scar
Clinical and Basic Research on the Necessity of Scar Tissue Resection During Intrauterine Adhesions
TCRA is an important surgical method to restore normal menstrual cycle and improve the outcome of pregnancy.However, postoperative intrauterine adhesion, uterine cavity deformation and difficulty in normal intimal growth…
- Trial name
- NCT05003869
- Testing
- Scar tissue is removed
- Where
- China
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Lili Cao
Asherman Syndrome, Intrauterine Adhesion
Evaluate Formation of IUAs After Third-generation Endometrial Ablation, With and Without Intrauterine Adhesion Barrier
Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier.
- Trial name
- CLEAN (NCT05414760)
- Testing
- Womed Leaf
- Where
- 2 sites in Netherlands
- Volunteers
- 1 people
- Sponsor
- Remko P. Bosgraaf
Infertility, Abortion, Spontaneous
Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions.
The main objective of this study is to describe the level of expression of the biological factors involved in the formation of adhesions (Transforming growth factor beta, Activin A, inhibin) at the time of a first diagnostic…
- Conditions
- Infertility, Abortion, Spontaneous, Embryo Implantation, Delayed
- Trial name
- PréSynUT-1 (NCT02328742)
- Testing
- Hysteroscopy + endometrial biopsy, Telephone call, Resection + endometrial biopsy
- Where
- 3 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
First Trimester Abortion, Surgical Abortion
New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT
The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester…
- Conditions
- First Trimester Abortion, Surgical Abortion, Miscarriage With Afibrinogenemia
- Trial name
- NCT05360186
- Testing
- MateRegen® gel (BioRegen)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Intrauterine Adhesions, Chronic Endometritis
Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Adhesions
This study is to evaluate the prevalence of chronic endometritis (CE) in women with severe intrauterine adhesions and compare recurrence of adhesion in women with and without CE.
- Trial name
- NCT02744807
- Testing
- Chronic endometritis
- Volunteers
- 125 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Intrauterine Adhesion
Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03346317
- Testing
- disposable balloon uterine stent, dried biological amnion graft, estradiol valerate tablets+dydrogesterone tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Uterine Synechiae After Scraping for Natural Miscarriage
Hyaluronic Acid and Uterine Synechiae
The primary purpose of the study is to compare efficiency of a non-stick gel application after scraping surgery for natural miscarriage with no non-stick gel application after scraping surgery.
- Trial name
- HYFACO (NCT02248376)
- Testing
- Gel
- Where
- France
- Volunteers
- 364 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asherman Syndrome, Abortion Late
Prevalence of Intrauterine Adhesions After D&C With or Without Antiadhesion Gel After Abortion in Second Trimester.
Only patients who sign an informed consent will be included. Patients after a miscarriage in the 2nd trimester of pregnancy who need to perform an instrumental revision of the uterine cavity (RCUI, revisio cavi uteri…
- Trial name
- ADAB (NCT04671914)
- Testing
- Hyaluronic Acid 20 MG/ML Injectable Solution, Dilation and curretage
- Where
- 3 sites in Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Intrauterine Adhesion, Asherman Syndrome
Platelet Rich Plasma in the Prevention of Adhesion Reformation
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium. It seems that the role of postoperative platelet rich plasma（PRP）therapy in the prevention of recurrence of IUA is still controversial.
- Trial name
- NCT06608407
- Testing
- PRP group
- Where
- 2 sites in China
- Volunteers
- 46 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Postoperative Adhesion of Uterus
Pivotal Clinical Study to Assess the Anti-adhesive Effect and Safety of ABT13107 Applied to Postoperative Intrauterine
This study is intended to evaluate the efficacy and safety of ABT13107 compared to Hyalobarrier applied to postoperative intrauterine.
- Trial name
- NCT04007211
- Testing
- ABT13107, Hyalobarrier
- Where
- South Korea
- Volunteers
- 192 people
- Sponsor
- Medy-Tox
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchyma Stem Cells
Study of the treatment of infertility caused by recurrent intrauterine adhesions (IUA) by collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (UC-MSCs) to provide clinical evidence of safety and…
- Trial name
- NCT02313415
- Testing
- UC-MSCs therapy
- Where
- China
- Volunteers
- 26 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Intrauterine Adhesion
Three-dimensional Ultrasound Applying in Assessment of Intrauterine Adhesions
In this prospective, multicenter, large-scale study，the investigators wish to examine the accuracy of several three-dimensional ultrasound anatomical and vascular parameters in diagnosing IUA when compared to the gold standard of…
- Trial name
- NCT04930913
- Testing
- Three-dimensional Ultrasound
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Retained Products of Conception, Intrauterine Adhesion
Hysteroscopy Assisted Suction Curettage for Early Pregnancy Loss
Retained products of conception (RPOC) and intrauterine adhesions (IUA) may occur following suction curettage for early miscarriage and cause secondary infertility, recurrent pregnancy loss and pregnancy complications.
- Trial name
- NCT04637373
- Testing
- Hysteroscopy
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Intrauterine Adhesions
Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy
Seprafilm is an FDA-approved temporary bioresorbable barrier that physically separates opposing tissue surfaces. The physical presence of the membrane separates adhesiogenic tissue while the normal tissue repair process takes…
- Trial name
- Seprafilm (NCT01632202)
- Testing
- Seprafilm, Sterile Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University