Clinical trials: Intrauterine Adhesion, open to volunteers
Intrauterine Adhesions
Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) caused by endometrial basal layer injury can lead to reduced menstrual flow, infertility, recurrent pregnancy loss, and poor reproductive outcomes.
- Trial name
- IPRF-IUA (NCT07536971)
- Testing
- Injectable Platelet-Rich Fibrin, Sodium Hyaluronate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Intrauterine Adhesions
hBMSC Uterine Artery Infusion for Severe IUA-Related Infertility
The goal of this clinical trial is to test a new approach: delivering human bone marrow mesenchymal stem cells (hBMSCs) via the uterine artery to treat infertility caused by severe intrauterine adhesions (IUA).
- Trial name
- NCT07176143
- Testing
- Delivering human bone marrow mesenchymal stem cells via the uterine artery
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Moderate-Severe Intrauterine Adhesions
A Study of GD007 (Human iPSC-Exosome Liquid Dressing) for Safety and Dose-Finding in Moderate-Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) remain highly prevalent in China, with incidence rates steadily increasing due to the rising number of intrauterine procedures.
- Trial name
- GD007 (NCT07101484)
- Testing
- GD007 Low-dose drug group, GD007 Mid-dose drug group, GD007 High-dose drug group
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pregnancy Complicated With Intrauterine Adhesion
Comparison of Operative Hysteroscopy and Vacuum Aspiration for Terminating First-trimester Pregnancy With Intrauterine Adhesions
In cases of early pregnancy complicated with intrauterine adhesions (IUAs), termination of pregnancy is prone to incomplete abortion with retained gestational products, failed abortion or uterine perforation due to altered…
- Trial name
- NCT07883057
- Testing
- Vacuum Aspiration Group, Hysteroscopy adhesiolysis combined with vacuum aspiration
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
First Trimester Abortion, Surgical Abortion
New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT
The objective of this prospective, randomized controlled study was to evaluate the effectiveness of this NCH gel in the prevention of IUA development as assessed by hysteroscopy after USG-MVA, in the treatment for first-trimester…
- Conditions
- First Trimester Abortion, Surgical Abortion, Miscarriage With Afibrinogenemia
- Trial name
- NCT05360186
- Testing
- MateRegen® gel (BioRegen)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Premature Ovarian Insufficiency, Intrauterine Adhesion
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Female fertility is affected by many factors, such as ovarian function, fallopian tube patency, uterine environment, and mental state, among which the ovaries and endometrium are more important.
- Conditions
- Premature Ovarian Insufficiency, Intrauterine Adhesion, Poor Ovarian Response, Repeated Implantation Failure
- Trial name
- NCT06645379
- Testing
- Platelet-Rich Plasma (PRP) Injections
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Thin Endometrial Lining, Female Infertility
Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study
The goal of this clinical trial is to evaluate if engineered mechanically umbilical cord-derived stem cell exosomes, or conventional umbilical cord -derived stem cell exosomes, can improve endometrial thickness in women with thin…
- Conditions
- Thin Endometrial Lining, Female Infertility, Intrauterine Adhesions
- Trial name
- NCT06896747
- Testing
- Mechanically Engineered Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes, Umbilical cord mesenchymal stem cell-derived exosomes, platelet-rich plasma
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Tang-Du Hospital
Myoma
Prevention of Intra-uterine Adhesions Following Laparoscopic and Laparotomic Myomectomy
Clinical study on the prevention of intrauterine adhesions after laparoscopic or laparotomic myomectomy. Myomas are common in women of reproductive age and myomectomy can lead to intra-uterine adhesions, which can be detrimental…
- Trial name
- PALLM (NCT05683041)
- Testing
- Hyalobarrier
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Early Abortion, Pregnancy Loss, Early
Comparison of Surgical Management of Early Pregnancy Loss by Suction Curettage Versus Hysteroscopy in Patients Undergoing In-vitro Fertilization (IVF)
Early pregnancy loss occurs in ~15% of pregnancies. The treatment options include surgical uterine evacuation by suction curettage, medical management with misoprostol, or conservative management without interventions.
- Trial name
- NCT07143578
- Testing
- Operative hysteroscopy using tissue removal device, suction curettage
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Intrauterine Adhesion
Investigating the Association Between Diagnostic and Therapeutic Management Models and Prognosis of Intrauterine Adhesions Based on a Large-Scale Prospective Cohort Study
This research plan aims to explore a new diagnosis and treatment management model for intrauterine adhesions and verify its efficacy and feasibility through a multicenter real-world study.
- Trial name
- NCT07421908
- Testing
- Transcervical resection of adhesion, Uterine cavity stent, Traditional Chinese medicine for tonifying the kidney
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Intrauterine Adhesion, Intrauterine Adhesions
To Evaluate the Safety and Effectiveness of Intrauterine Adhesion Preventer in the Prevention and Treatment of Intrauterine Adhesions, a Prospective, Multicenter, Randomized Controlled Clinical Trial
To evaluate the effect of uterine stents in preventing intrauterine adhesions after intrauterine operation and whether they meet the safety requirements for clinical use.
- Trial name
- NCT07611474
- Testing
- Uterine stent group, Uterine ring + balloon + sodium hyaluronate gel
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Intrauterine Adhesion
Heparin Solution Versus Anti-adhesion Barrier Gel for Intrauterine Adhesions Prevention After Operative Hysteroscopy
The aim of this study is to compare the efficacy of intrauterine application of heparin solution to the use of hyaluronic acid barrier gel for the prevention of intrauterine adhesion formation after operative hysteroscopy.
- Trial name
- NCT05257213
- Testing
- Heparin solution, Anti-adhesion barrier gel
- Where
- 2 sites in Bulgaria
- Volunteers
- 100 people
- Sponsor
- Nadezhda Women's Health Hospital
Endometrium; Atrophy, Intrauterine Synechiae
AD-SVF Therapy for Refractory Endometrial Infertility
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
- Trial name
- NCT07230600
- Testing
- AD-SVF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Myoma;Uterus, Adhesion; Uterus, Internal
Incidence of Intrauterine Adhesions After Myomectomy With Intrauterine Anti-Adhesion Gel
This prospective randomized study aims to evaluate whether the application of an intrauterine anti-adhesion gel reduces the incidence of intrauterine adhesions (IUAs) following robotic-assisted laparoscopic myomectomy.
- Trial name
- NCT07280286
- Testing
- Women will receive the application of an anti-adhesion gel at the end of the myomectomy procedure
- Volunteers
- 62 people
- Sponsor
- Federico II University
Retained Products of Conception
The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception
Retained product of conception (RPOC) is defined by abnormal trophoblastic persistence or retained placenta inside the uterus cavity after a pregnancy independently of the outcome. Untreated RPOC can compromise future fertility.
- Trial name
- NCT05085067
- Testing
- auto-crossed-linked hyaluronic acid gel
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Intrauterine Abnormalities in Infertility, Asherman Syndrome
Safety and Performance of the Semical Adhesion Barrier Gel for Prevention of Intra-uterine Adhesion
The aim of this study was to obtain short- and long-term performance and safety data of cross-linked hyaluronic acid-based adhesion barrier gel used to prevent intrauterine adhesion formation.
- Conditions
- Intrauterine Abnormalities in Infertility, Asherman Syndrome, Intra-uterine Adhesions, Postoperative Adhesion of Uterus
- Trial name
- SEMFERTIL (NCT07160764)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Intrauterine Adhesion
Intrauterine Stent Placement Following Hysteroscopic Septum Resection
The study hopes to learn the best way to prevent internal scar tissue after septum removal. The use of an intrauterine foley catheter balloon may prevent the formation of adhesions following surgery.
- Trial name
- NCT07032506
- Testing
- Intraoperative placement of an inflated intrauterine pediatric foley catheter, No Catheter placement, Hormonal Therapy Agent
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Weill Medical College of Cornell University