Clinical trials: Intrauterine Device (IUD)
Long-term and Permanent Contraceptive Methods
A Prospective Observational Study of the Clinical Performance of Zarin in Madagascar
This one-year observational study will monitor the contraceptive effectiveness, safety and acceptability of Zarin during the first year of use after the method has been approved for public use in Madagascar.
- Trial name
- NCT01200576
- Where
- Madagascar
- Volunteers
- 621 people, healthy volunteers welcome
- Sponsor
- FHI 360
Family Planning
Indomethacin Use in Pain Relief During Intrauterine Device Insertion
The aim of the investigators study is to test the analgesic effect of rectal indomethacin during Intrauterine device insertion.
- Trial name
- INDO-IUD (NCT02711358)
- Testing
- indomethacin suppositories
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Intrauterine Device
Can Uterocervical Angle Predict the Displacement of Copper Intrauterine Devices (T-Cu 380A)
The investigators conducted a case-control study between December 2020-June 2021 at Istanbul Health Sciences University Kanuni Sultan Suleyman Training and Research Hospital family planning outpatient clinics.
- Trial name
- NCT05556421
- Testing
- uterocervical angle
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Contraception
Bleeding Pattern Difference Between Levonorgestrel Intrauterine System (LNG-IUS) and Copper Intrauterine Devices (IUDs) Immediately Inserted After Abortion
To observe the bleeding patterns of post-abortion immediate insertion of IUS compared to Cu-IUD over the first 6 months.
- Trial name
- POST (NCT01958684)
- Testing
- Levonorgestrel IUS (Mirena, BAY86-5028), Copper-IUD
- Where
- China
- Volunteers
- 512 people
- Sponsor
- Bayer
Cervical Stenosis
Use of Misoprostol in Case of Insertion Failure of Intrauterine Contraceptives
To assess the usefulnes sof misoprostol versus placebo (in a double-blind placebo controlled randomized clinical trial)to facilitate the insertion of copper-IUD and the levonorgestrel-releasing intrauterine system (LNG-IUS) in…
- Trial name
- NCT01754649
- Testing
- Misoprostol
- Where
- 2 sites in Brazil
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Luis Bahamondes
Anxiety, Pain Management
Virtual Reality-Assisted Nursing Intervention During Intrauterine Device Insertion
This randomized controlled trial evaluated the effects of a virtual reality-supported nursing intervention based on Kolcaba's Comfort Theory on women's comfort, emotional state, pain and physiological parameters during…
- Conditions
- Anxiety, Pain Management, Virtual Reality, Nursing Interventions
- Trial name
- VR-IUD (NCT07580885)
- Testing
- via virtual reality goggles
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mersin University
Atypical Endometrial Hyperplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating Patients With Atypical Hyperplasia or Stage IA Grade 1 Endometrial Cancer
This randomized phase II trial studies how well levonorgestrel-releasing intrauterine system works when given alone or with everolimus in treating patients with atypical hyperplasia (a pre-cancerous growth of the lining of the…
- Conditions
- Atypical Endometrial Hyperplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
- Trial name
- LEVER (NCT02397083)
- Testing
- Everolimus, Laboratory Biomarker Analysis, Levonorgestrel-Releasing Intrauterine System
- Where
- 18 sites in United States
- Volunteers
- 102 people
- Sponsor
- M.D. Anderson Cancer Center
Contraception, HIV
HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC
This study is being done to understand if using birth control causes changes in the immune cells within the reproductive tract of healthy women.
- Conditions
- Contraception, HIV, Immune Cells (Mucosal and Systemic), Microbiota
- Trial name
- Zim CHIC (NCT02038335)
- Testing
- DMPA, NET-EN, MPA/E2
- Where
- Zimbabwe
- Volunteers
- 451 people
- Sponsor
- University of Pittsburgh
Pain Control With IUD Insertion
Pain Control for Intrauterine Device Placement: A Trial of Ketorolac Prior to Intrauterine Device Placement
Intrauterine device (IUD) placement can be painful for patients during and after the procedure. Fear of pain from IUD insertion can be a barrier to obtaining this highly effective long acting reversible contraception.
- Trial name
- NCT01664559
- Testing
- Ketorolac, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Lynn Ngo
IUD Insertion
Comparison of Pain Level During Intrauterine Device (IUD) Insertion Between Conventional and Direct Method
The so-called "direct" method of intrauterine device (IUD) and intraintuerine system (IUS) insertion is increasingly used. A study has shown that it is technically simpler and assumes less painful than the classic pose.
- Trial name
- KIDDS (NCT03473717)
- Testing
- classic method, direct method
- Where
- 10 sites in France
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Contraception
A Study to Compare 3 Doses of a Hormonal Intra-uterine Device Containing Levonorgestrel and Indomethacin With a Hormonal Intra-uterine Device Containing Only Levonorgestrel to Assess the Effect and Safety of the Combined Components
This study is the first study investigating the combined intrauterine administration of LNG (levonorgestrel) and IND (indomethacin). It is a combined proof-of-concept (PoC) and dose finding (DF) study in pre-menopausal women.
- Trial name
- INDessa (NCT03562624)
- Testing
- BAY98-7443, Levonogestrel (Skyla, BAY86-5028)
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Bayer
IUCD Complication
Vaginal Isonicotinic Acid Hydrazide (INH) Administration Prior to T380A Intrauterine Device Insertion
To investigate whether vaginal isonicotinic acid hydrazide administered before intrauterine device (IUD) insertion reduces failed insertions, insertion-related complications and pain in in Women Delivered Only by Cesarean…
- Trial name
- NCT04499989
- Testing
- INH
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Aswan University Hospital
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
This phase II trial studies whether adding tirzepatide injections to a levonorgestrel intrauterine device (LNG-IUD) improves pathologic response (absence of cancer cells in tissue samples after treatment) in women with…
- Trial name
- NCT07349641
- Testing
- Medical Device Usage and Evaluation, Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Reversible Prevention of Pregnancy
A Study on the Safety and Efficacy of the SCu300A IUB Compared to the TCu380 Copper IUD
This study aims to evaluate the safety and efficacy of the IUB SCu300A spherical copper IUD compared to the standard T shaped copper IUD, the TCu380.
- Trial name
- NCT02036203
- Testing
- SCu300A IUB, TCu380A IUD
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ocon Medical Ltd.
Pain
Cervical Lidocaine for Intrauterine Device Insertion Pain
The aim of this study is to evaluate intracervical lidocaine gel as a means to decrease pain associated with intrauterine device (IUD) insertion.
- Trial name
- CLIIP (NCT01411995)
- Testing
- 2% lidocaine gel, Water based lubricant
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Contraception
Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial
This is a pilot study to determine the feasibility for a randomized controlled trial of two forms of intrauterine contraception: the Levonorgestrel intrauterine system (LNG-IUS) and the Copper T 380A.
- Trial name
- MINT (NCT00653159)
- Testing
- Levonorgestrel-releasing intrauterine device (LNG-IUS), Copper T380A intrauterine device (CuT380A)
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy
Postplacental Insertion of Levonorgestrel-releasing Intrauterine System (LNG-IUS) After Cesarean vs. Interval Insertion
The study is a randomized controlled trial comparing outcomes of immediate postplacental insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS) vs.
- Trial name
- NCT00635362
- Testing
- Levonorgestrel-releasing intrauterine system (LNG-IUS)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Chicago
IUD Insertion Pain
Celecoxib Versus Hyoscine Butyl-bromide in Reducing Pain Associated With IUD.
Many oral analgesic drugs such as the nonsteroidal anti-inflammatory drug (NSAID) are used to relieve pain from gynaecological procedures and dysmenorrhea.
- Trial name
- NCT03499743
- Testing
- hyoscine butyl bromide, Celecoxib 200mg
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cairo University
Contraception
Music as a Nonpharmacologic Approach to Pain Control With Intrauterine Device Placement
The intervention of this study is the addition of patient-selected music during IUD insertion procedure. Subjects randomized to the music group will choose 10 songs, which will be played during the procedure, from the time of…
- Trial name
- NCT04835701
- Testing
- Music
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postpartum Period
Bleeding Patterns and Complications After Postpartum IUD Placement: a Pilot Study
The purpose of the study is to determine the feasibility of placing the levonorgestrel-releasing intrauterine system (LNG - IUS, Mirena®) post-delivery.
- Trial name
- NCT01309919
- Testing
- IUD, Diary
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Baystate Medical Center