Clinical trials: Intrauterine Systems
Analgesia
Optimizing Analgesia for Endometrial Biopsy
Comparison of the effectiveness of intrauterine lidocaine-paracervical block-dexketoprofen tromematol- lidocaine spray in endometrial biopsy analgesia
- Trial name
- NCT06540599
- Testing
- Analgesic
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Atypical Endometrial Hyperplasia
LVN- IUS Versus Oral Megesterol Acetate in Treatment of Atypical Endometrial Hyperplasia
This randomized controlled trial is aimed to compare the efficacy between Megestrol acetate (MA) and the levonorgestrel intrauterine system (LNG-IUD) regarding the ability and duration to produce complete regression for cases…
- Trial name
- NCT04385667
- Testing
- levonorgestrel intrauterine system (LNG-IUD), Oral Megesterol 160 mg daily
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Zagazig University
Infertility, Infertility Secondary
Sperm Preparation Prior to Intrauterine Insemination Study
This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.
- Conditions
- Infertility, Infertility Secondary, Infertility Unexplained, Anovulation
- Trial name
- PIoUS (NCT05693220)
- Testing
- Zymot Multi sperm separation device, Density gradient centrifugation
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of California, San Francisco
Infertility
The Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination
According to the studies CC is successful at inducing ovulation in 50%-75% of cases, but only 30-40% becomes pregnant. The difference has been attributed to a negative action of clomifen citrate(CC) in the form of prolonged…
- Trial name
- NCT01219101
- Testing
- clomiphene citrate with ethinyl esteradiol, clomiphene citrate with plasebo
- Where
- Iran
- Volunteers
- 95 people
- Sponsor
- Royan Institute
Adenomyosis
LNG-IUS for Treatment of Dysmenorrhea
Adenomyosis is a disease entity diagnosed when endometrial glands and stroma deep in the myometrium are associated with surrounding myometrial hypertrophy.
- Trial name
- LNGIUSAD (NCT01601366)
- Testing
- LNG-IUS, Combined oral contraceptives
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Omar Mamdouh Shaaban
High Risk Pregnancy, Congenital Heart Disease
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome.
- Conditions
- High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta
- Trial name
- NCT03775954
- Testing
- Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Intrauterine Adhesion
Efficacy of Estrogen-intrauterine Stent System After Intrauterine Adhesiolysis
This is a prospective, randomized, single-blinded,multi-center trial to compare the efficacy of an Estrogen-intrauterine stent system with foley balloon combined with intrauterine cross-linked sodium hyaluronate gel in the…
- Trial name
- NCT04972032
- Testing
- Estrogen Intrauterine Stent System, Foley balloon combined with self-cross-link sodium hyaluronate gel
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Limin Feng
Intrauterine Device
Vaginal Dinoprostone Administration Prior to Insertion Levonorgestrel-releasing Intrauterine System in Women With no Previous Vaginal Delivery
To investigate whether vaginal dinoprostone administered before the levonorgestrel-releasing intrauterine system(IUs) insertion reduces failed insertions, insertion-related complications, and pain in Women With no Previous…
- Trial name
- NCT04045548
- Testing
- Dinoprostone
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Pain
Intrauterine Lidocaine Infusion for Essure Sterilization Procedures
The purpose of this study is to assess the level of pain women experience with an Essure procedure and the effect that lidocaine might have on that pain.
- Trial name
- NCT00613834
- Testing
- Lidocaine, Sterile Saline
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Contraception
LCS12 vs Combined Oral Contraceptive (COC) User Satisfaction Study
The primary objective of this study is to evaluate user satisfaction and tolerability in young women (18-29 years of age) using the LCS12 compared with young women using a COC (Yasmin) over a period of 18 months.
- Trial name
- NCT01254292
- Testing
- Levonorgestrel IUD (LCS, BAY86-5028), Yasmin (EE30/DRSP, BAY86-5131)
- Where
- 94 sites in United States, Austria and 3 more
- Volunteers
- 567 people
- Sponsor
- Bayer
Intrauterine Adhesions
The Efficacy and Safety of the Dried Biological Amnion Graft in Patients With Intrauterine Adhesions
To estimate the efficacy and safety of dried biological amnion graft after hysteroscopic lysis of intrauterine adhesions.
- Trial name
- NCT02496052
- Testing
- dried biological amnion graft, Foley balloon, estradiol valerate tablets+dydrogesterone Tablets
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Intrauterine Adhesion
Safety and Effectiveness of Juveena™ Hydrogel System Following Transcervical Gynecologic Procedures (TCGP) At High-Risk for Intrauterine Adhesions
This study is to determine whether intrauterine instillation of Juveena hydrogel following adhesiogenic hysteroscopic procedures (TCGP + Juveena) can safely and effectively reduce the incidence and severity of intrauterine…
- Trial name
- NCT05394662
- Testing
- Juveena Hydrogel System, Transcervical Gynecologic Procedures (TCGP)
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- Rejoni Inc.
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Use of Nitrous Oxide During Office Hysteroscopy
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: Does it reduce pain during the procedure? Does it increase the success rate? Does…
- Conditions
- Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps, Retained Products of Conception
- Trial name
- NCT07074795
- Testing
- Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy, inhalation of ambient air during office hysteroscopy
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Maaynei Hayesha Medical Center
Hysteroscopy
Postoperative Analgesic Efficacy of Tetracaine Hydrochloride Gel
This study was taken out to assess the postoperative analgesic efficacy of tetracaine hydrochloride gel in patients with intrauterine adhesion treating with intrauterine balloon.Participates were assigned into two groups by…
- Trial name
- NCT02863679
- Testing
- Tetracaine hydrochloride gel
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Wenzhou Medical University
Endometriosis
Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis
Randomized clinical trial the use of levonorgestrel releasing intrauterine system. Objectives: To evaluate and compare the efficacy of- levonorgestrel releasing intrauterine system l(LNG-IUS) in relation to the subdermal implant…
- Trial name
- NCT02480647
- Testing
- Levonorgestrel, Etonogestrel
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Menorrhagia
Hysterectomy and Levonorgestrel Releasing Intrauterine System (LNG-IUS) in the Treatment of Menorrhagia
A randomised study including 236 women referred for essential menorrhagia to five university hospitals in Finland was conducted to compare the cost-effectiveness and the quality of life issues in the treatment of…
- Trial name
- VUOKKO (NCT00966264)
- Testing
- LNG-IUS, Hysterectomy
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
HIV-1, Fertility
Intrauterine Insemination In HIV-Discordant Couples
This study aims to assess the feasibility of a novel standard of care technique for intrauterine insemination (IUI) in HIV-discordant couples in the United States.
- Conditions
- HIV-1, Fertility, Infertility
- Trial name
- ARTEMIS (NCT01173276)
- Testing
- Sperm Washing with Intrauterine Insemination (IUI)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Medical Center
Fetal Macrosomia, Intrauterine Growth Disorders (IUGR and Macrosomia)
Estimation of Fetal Weight by Measuring Abdominal Circumference, Abdominal Subcutaneous Soft Tissue Thickness, Femur Length and Mid-thigh Soft Tissue Thickness
Traditional methods for estimating fetal weight (EFW) often miss the mark because they focus on bone and circumference while ignoring fetal fat. This study proposes a more inclusive formula to fix that.
- Conditions
- Fetal Macrosomia, Intrauterine Growth Disorders (IUGR and Macrosomia), Intrauterine Growth Restriction (IUGR)
- Trial name
- NCT07575152
- Testing
- 3rd trimester ultrasound examination within 48-72 hours of delivery
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hemoglobin; Deficiency
Effect of Levonorgestrel Intrauterine System on Hemoglobin Level
To study the effect of LNG-IUS on improving iron status in reproductive-aged women presenting for contraception.
- Trial name
- NCT06935968
- Testing
- Levonorgestrel intrautrine system
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tubal Ligation
Levonorgestrel-releasing Intrauterine System and Tubal Ligation
Today tubal sterilization is a simple, safe, and cost-effective method of achieving long-term contraception. Sterilization is an ideal method of permanent contraception in developing countries where access to health care…
- Trial name
- NCT04663568
- Testing
- Levonorgestrel-releasing intrauterine system
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Assiut University