Clinical trials: Intravenous
Malaria, Severe Malaria
Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
Background: Malaria is caused by small parasites carried by some mosquitoes. People can get malaria if an infected mosquito bites them. Malaria destroys red blood cells.
- Trial name
- NCT01955382
- Testing
- Actidose Aqua, Artesunate, Amodiaquine
- Where
- Mali
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pain, Fever
Safety and Pharmacokinetic Study of Intravenous Ibuprofen in Pediatric Patients
The primary objective of this study is to evaluate the pharmacokinetic profile of a single dose of intravenous ibuprofen administered over approximately ten (10) minutes.
- Trial name
- NCT02583399
- Testing
- Ibuprofen
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cumberland Pharmaceuticals
Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma
Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery
This randomized phase II trial studies how well pazopanib hydrochloride with or without ascorbic acid work in treating patients with kidney cancer that has spread to other places in the body (metastatic) or cannot be removed by…
- Conditions
- Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT03334409
- Testing
- Ascorbic Acid, Pazopanib Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Academic and Community Cancer Research United
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
Azacitidine in Patients Undergoing Matched Unrelated Stem Cell Transplantation
The purpose of this phase I/II study is to define the maximum tolerated dose of 5-AzaC and the effect on grade II-IV GvHD when given after matched unrelated donor transplant (MUD).
- Conditions
- Leukemia, Myeloid, Acute, Myelodysplastic Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Trial name
- NCT01747499
- Testing
- Azacitidine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Washington University School of Medicine
End Stage Renal Disease
Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
This single center, Phase I/II, exploratory study has been modified to a safety/efficacy study providing all patients with IVIG and Rituximab.
- Trial name
- NCT01178216
- Testing
- Rituxan
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanley Jordan, MD
Neoplasms
Study of PF-05212384 (Also Known as PKI-587)Administered Intravenously To Subjects With Solid Tumors
This is a two-part study of a compound called PF-05212384 (also known as PKI-587). The purpose of part 1 is to identify the Maximum Tolerated Dose (MTD) of PF-05212384 using a Continual Reassessment Method (CRM).
- Trial name
- B2151001 (NCT00940498)
- Testing
- PF-05212384 (also known as PKI-587)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 78 people
- Sponsor
- Pfizer
Pain
Vapocoolant Spray Used Prior to Intravenous (IV) Insertions
The primary purpose of this study is to determine if by offering a vapocoolant (cold spray) to hospital outpatients prior to an intravenous catheter (IV) insertion will increase patient satisfaction of IV insertion as well as…
- Trial name
- NCT03054740
- Testing
- Gebauer Ethyl Chloride, Nature's Tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aultman Health Foundation
Cervical Spine
Effect of Local Steroid Application on a Cervical Plate Versus Intravenous Steroids on Dysphagia Following Anterior Cervical Discectomy and Fusion (ACDF)
Local application of steroids in ACDF surgery will lead to decreased incidence of dysphagia compared to intravenous steroids or a control group
- Trial name
- NCT02577991
- Testing
- Decadron, Triamcinolone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Gastrointestinal Motility Disorder
A Phase 1, Multiple Intravenous Dose Study to Examine Safety, Tolerability, and PK of Intravenous TD-8954, a 5-HT4 Receptor Agonist, in Healthy Subjects
This is a single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics (PK) of repeated IV doses of TD-8954 in healthy adults 18 to 45 years of age and healthy…
- Trial name
- NCT01644240
- Testing
- TD-8954
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Idiopathic Scoliosis
Anesthesia During Neurophysiologic Monitoring in Scoliosis Patients
When patients have spinal surgery, electrodes are placed on the body to measure motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP).
- Trial name
- NCT01549873
- Testing
- propofol, Desflurane
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nationwide Children's Hospital
Neoplasms
Weekly Intravenous Administrations of BI 836845 in Japanese Patients With Advanced Solid Tumours
This open-label dose escalation phase I trial, 1280.15, is with the first administration of BI 836845 in Japanese patients with various types of advanced solid tumours.
- Trial name
- NCT02145741
- Testing
- 750 milligram Xentuzumab, 1000 milligram Xentuzumab, 1400 milligram Xentuzumab
- Where
- Japan
- Volunteers
- 21 people
- Sponsor
- Boehringer Ingelheim
Abscess, Pain
Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children
Children can develop abscesses (a collection of pus under their skin) that require a physician to cut it open to let the pus drain out. This is a painful procedure.
- Trial name
- NCT01549002
- Testing
- Intranasal Fentanyl, Intravenous Morphine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Epilepsy, Benign Neonatal
Efficacy and Safety of Intravenous Phenobarbital in Neonatal Seizures
This is a randomized, double-blind, parallel-group, Phase 3 study to evaluate the efficacy of the administration of phenobarbital sodium injection in neonates who have suffered from electrographic or electroclinical seizure.
- Trial name
- NCT04320940
- Testing
- Phenobarbital Sodium Injection
- Where
- 8 sites in United States, Jordan
- Volunteers
- 4 people
- Sponsor
- NEMA Research, Inc.
Arthritis, Rheumatoid
A Golimumab Phase 3b, Multicenter, Assessment of Intravenous Efficacy in Rheumatoid Arthritis Subjects Who Have Diminished Disease Control Despite Treatment With Infliximab (REMICADE®)
This is a Phase 3b, multicenter study of the efficacy of golimumab 2 mg/kg IV in subjects with active rheumatoid arthritis who are receiving methotrexate and have inadequate disease control (defined as an erythrocyte…
- Trial name
- REGAIN (NCT01962974)
- Testing
- Golimumab 2 mg/kg IV
- Where
- 52 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- Janssen Biotech, Inc.
Surgical Procedure, Unspecified
Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery
Two hundred children aged 1-12 years undergoing short surgery will be randomized into two groups. Ketofol will be used for induction and maintenance of anesthesia in group l. .Ketofol with lidocaine will be prepared for group ll.
- Trial name
- Lidoketofol (NCT04467424)
- Testing
- ketamine, propofol, ketamine, propofol, lidocaine
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University Hospital of Split
Status Epilepticus
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
- Trial name
- RAMPART (NCT00809146)
- Testing
- Intramuscular route of active treatment, Intravenous route of active treatment
- Where
- 17 sites in United States
- Volunteers
- 1,023 people
- Sponsor
- Robert Silbergleit
Fallopian Tube Cancer, Ovarian Cancer
S9912 Combination Chemo in Stage III Ovarian Cancer,
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- NCT00003896
- Testing
- cisplatin, liposomal doxorubicin, paclitaxel
- Where
- 104 sites in United States
- Volunteers
- 68 people
- Sponsor
- SWOG Cancer Research Network
Pain
A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management
Hypothesis: Intravenous administration of Ketorolac in a dose of 10 mg is as effective in treating severe acute pain in patients presenting to the ED as 15 mg and 30 mg.
- Trial name
- NCT02078492
- Testing
- 10 mg of Ketorolac, 15 mg of Ketorolac, 30 mg of Ketorolac
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Pain, Local Anesthesia for Peripheral Intravenous Catheterization
Local Anesthetics for Pain Reduction Prior to IV Line Placement
The purpose of this study is to compare the pain level felt by patients when receiving placement of a peripheral intravenous catheter (IV line) following the administration of a local anesthetic.
- Trial name
- NCT01759459
- Testing
- Lidocaine, Buffered Lidocaine, Bacteriostatic Normal Saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Lung Injury, Acute
SB-681323 IV for Subjects at Risk of Acute Lung Injury or ARDS
This is an early phase (Phase IIa), randomized, double-blind, parallel group, multi-centre study for subjects with trauma (physical injury) who are at risk for developing Acute Lung Injury (ALI) or Acute Respiratory Distress…
- Trial name
- NCT00996840
- Testing
- SB-681323 Intravenous 3mg, SB-681323 Intravenous 7.5 mg, SB-681323 Intravenous 7.5mg
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
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