Clinical trials: Intravenous
Regional Anesthesia Morbidity
Dexmedetomidine in IVRA
A prospective randomized controlled double-blinded study will be conducted on 90 patients assigned randomly into three equal groups,
- Trial name
- NCT05123170
- Testing
- Dexmedetomidine Injectable Solution [Dexdomitor], Lidocaine IV
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Coronary Artery Disease, Postoperative Complications
Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers
The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative…
- Conditions
- Coronary Artery Disease, Postoperative Complications, Anesthesia
- Trial name
- NCT06209437
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people
- Sponsor
- Ankara City Hospital Bilkent
Anemia
A Study of Intravenous Mircera for the Treatment of Anemia in Dialysis Patients.
This study will assess the efficacy and safety of intravenous (iv) Mircera given as maintenance treatment for renal anemia in chronic kidney disease patients on dialysis who were previously receiving iv darbepoetin alfa.
- Trial name
- NCT00077766
- Testing
- Darbepoetin alfa, methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 48 sites in Australia, Austria and 10 more
- Volunteers
- 313 people
- Sponsor
- Hoffmann-La Roche
Hemorrhoids Second Degree, Hemorrhoids Third Degree
A Clinical Trial of Local Infiltration With Injection CZ1S for Postoperative Analgesia After Hemorrhoidectomy
This is a multicenter, randomized, double-blind, active-controlled and placebo-controlled phase III clinical trial, aiming to evaluate the efficacy and safety of intravenous injection of CZ1S for local infiltration after…
- Conditions
- Hemorrhoids Second Degree, Hemorrhoids Third Degree, Analgesia
- Trial name
- NCT07909902
- Testing
- CZ1S for injection, ropivacaine, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Zhejiang Cuize Pharmaceutical Technology Co., Ltd.
Diabetes Mellitus
Transitioning Open Heart Surgery Patients From Insulin Infusions to Detemir
In this study we will determine the proper method for transitioning patients from a continuous insulin infusion to periodic injections of a newer long-acting insulin called detemir (Levemir).
- Trial name
- NCT00717288
- Testing
- Detemir
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Ohio State University
Extensive Stage-Small Cell Lung Cancer
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) ABBV-706 in Combination With Tarlatamab and Atezolizumab in Adult Participants With Extensive Stage-Small Cell Lung Cancer
Small cell lung cancer (SCLC) is a type of lung cancer that accounts for approximately 15-17% of all lung cancers. It is characterized by aggressive and rapid growth and early spread to distant sites.
- Trial name
- NCT07895056
- Testing
- ABBV-706, Tarlatamab, Atezolizumab
- Volunteers
- 80 people
- Sponsor
- AbbVie
Refractory Respiratory Failure
Intravenous Continuous LMWH Seems to be Safe Alternative to UFH in VV ECMO Patients
Unfractionated heparin (UFH) is worldwide anticoagulation used and recommended anticoagulation in patients with ECMO support. However, it is accompanied with incidence of bleeding or thrombotic compliaction at about 40-60% and…
- Trial name
- NCT06010446
- Testing
- No intervention, just retrospective analysis of data.
- Where
- Czechia
- Volunteers
- 43 people
- Sponsor
- University Hospital, Motol
Hypovolemia
Plasma-Lyte 148® versUs Saline Study
The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality…
- Trial name
- PLUS (NCT02721654)
- Testing
- Plasma-Lyte 148®, 0.9% sodium chloride
- Where
- 51 sites in Australia, New Zealand
- Volunteers
- 5,037 people
- Sponsor
- The George Institute
Hemorrhagic Fever With Renal Syndrome
Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany
This is a treatment protocol using IND Ribavirin-there is no control group. Hemorrhagic Fever with Renal Syndrome (HFRS) is caused by a virus acquired by contact with chronically infected rodent hosts.
- Trial name
- HFRS (NCT00868946)
- Testing
- Virazole (Ribavirin)
- Where
- Germany
- Sponsor
- U.S. Army Medical Research and Development Command
Alzheimer's Disease
A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease
This is a Phase I, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics, and preliminary activity of RO7105705 in two participant populations: healthy participants and…
- Trial name
- NCT02820896
- Testing
- RO7105705
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Systemic Lupus Erythematosus, Rheumatoid Arthritis
Safety and Efficacy of Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome
This is a Phase I-II open- label single-dose study in subjects with significant refractory Rheumatoid Arthritis (RA), relapsing Systemic Lupus Erythematosus (SLE) or Sharp's Syndrome (SS).
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sharp's Syndrome
- Trial name
- NCT02741362
- Testing
- Intravenous injection of Stromal Vascular Fraction Cells (SVF) containing ADSCs, Lipoaspiration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Arkansas Heart Hospital
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing cardiac surgery at the…
- Trial name
- DEPOSITION (NCT03376061)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Severe Traumatic Pain, Numeric Pain Rating Scale > 5 / 10
Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting
Intranasal (IN) administration of opiates is an appealing non-invasive way of treating acute traumatic pain in prehospital and Emergency departments (ED).
- Trial name
- ALGOFINE-2 (NCT02095366)
- Testing
- Morphine, Sufentanil
- Where
- 6 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Grenoble
Pruritus
Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
Neuraxial anesthesia, which includes epidural anesthesia and intrathecal anesthesia, is a frequent anesthetic approach for caesarean delivery and other lower abdominal and lower limb anesthetic procedures.
- Trial name
- NCT03483870
- Testing
- Morphine Sulfate, Granisetron
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hematologic Malignancies
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
SLS009 (formerly GFH009) is a potent and highly selective CDK9 inhibitor. In this study the safety, tolerability, and antitumor activity of single agent SLS009 are assessed in two dose escalation groups (Group 1 in patients with…
- Trial name
- NCT04588922
- Testing
- SLS009, venetoclax, azacitidine
- Where
- 32 sites in United States, China
- Volunteers
- 160 people
- Sponsor
- Sellas Life Sciences Group
Femur Head Necrosis
Anesthesia Depth's Influence on Postoperative Delirium
The investigators,according to the eligibility criteria,plane to choose 80 elderly anticipates who will undergo selective hip replacement surgery.This participants will be randomly divided into 2 groups:light anesthesia depth…
- Trial name
- NCT02972762
- Testing
- Diprivan
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiangya Hospital of Central South University
Systemic Immune Activation, Cancer Gi
The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries
The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer…
- Conditions
- Systemic Immune Activation, Cancer Gi, Cancer of Endometrium
- Trial name
- NCT04891146
- Testing
- Systemic inflammatory immmune index
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Aspergillosis, Influenza
Pharmacokinetics of Voriconazole in Adult ECMO Patients
Given the high burden of fungal co-infection in patients admitted to ICU and improved outcomes with prompt anti-fungal treatment, it is of vital importance that the doses of anti-fungal are optimum to improve the dismal outcome…
- Conditions
- Aspergillosis, Influenza, Covid19
- Trial name
- NCT04868188
- Testing
- 5 blood samples, Determination of CYP2C19 genotype
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospitals, Leicester
Gastric Cancer, Pain, Postoperative
Comparison of the Effect of Intravenous and Perineural Dexmedetomidine in Gastric Cancer Surgery
Using random case assignment to investigate the analgesic and sedative effect of intravenous dexmedetomidine and dexmedetomidine as a local anesthetic adjuvant in ultrasound-guided subcostal TAP block in gastric cancer patient…
- Trial name
- NCT03393403
- Testing
- Dexmedetomidine, 0.9% Sodium-chloride
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Organ Protection
The Effect of Intravenous Lidocaine on Postoperative Cognitive Function in Elderly Patients
The purpose of this study is to investigate the efficacy of intravenous lidocaine on BDNF, NGF, miRNA-206 and miRNA-98 in serum in elderly patients undergoing abdominal surgery under general anesthesia.
- Trial name
- NCT05502705
- Testing
- Lidocaine, Normal saline (NS)
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
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