Clinical trials: Intravenous Fluid Therapy
Benign Neoplasms, Vascular Malformations, Brain
Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery
The purpose of this study was to investigate whether the balanced fluids therapy change plasma osmolality in neurosurgical procedures due to brain tumors, meningeomas and arterio-venous malformation.
- Trial name
- NCT03429127
- Testing
- Normal saline, Balanced fluid
- Where
- Croatia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Centre Zagreb
Diabetic Ketoacidosis
Two Bag System for Diabetic Ketoacidosis
This is a study investigating the best way to treat diabetic ketoacidosis (DKA) with intravenous (IV) fluids in the hospital. The purpose of this study is to determine whether the "two bag" system of administering IV fluids for…
- Trial name
- 2BagDKA (NCT03660189)
- Testing
- Two bag system
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- MetroHealth Medical Center
Anesthesia
Automated Administration of Fluids Guided by Dynamic Parameters and Cardiac Output During General Anesthesia
The main objective of this study is to demonstrate that the LIR (Learning Intravenous Resuscitator) Closed-Loop Fluid Administration System (hereafter the "LIR system"), a new device for the automated administration of…
- Trial name
- Closed Loop (NCT02138942)
- Testing
- Learning Intravenous Resuscitator (LIR) system
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Pancreatitis
Evaluation of Intravenous Fluid Therapy Within Dallas Acute Pancreatitis Protocol
Acute pancreatitis (AP) is a common disease of the gastrointestinal tract that can result in emotional, physical, and financial burdens on the patient.
- Trial name
- NCT06223594
- Testing
- Intravenous Fluid Therapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Methodist Health System
Cardiac Surgery
An Assessment of Pulse Pressure Variation to Guide Fluid Therapy in Cardiac Surgery Patients
We aim to test the hypothesis that fluid therapy based on pulse pressure variation (PPV) in patients after cardiac surgery who are mechanically ventilated leads to a significant decrease in the amount of fluid given to such…
- Trial name
- NCT01681758
- Testing
- IV fluid according to PPV, fluids according to standard care
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- Austin Health
Infiltration, Extravasation
Monitoring the Peripheral Intravenous Infusion Site for Infiltration and Extravasation
The purpose of this study to to monitor the peripheral intravenous (PIV) site on subjects receiving continuous IV fluids for infiltration and extravasation events.
- Conditions
- Infiltration, Extravasation, IV Infiltration, IV Extravasation
- Trial name
- NCT01476293
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- ivWatch, LLC
Pneumonia
A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia
Pneumonia is one of the top causes of death in children aged below 5. More than 10% of children with severe pneumonia die. We are not sure that the currently recommended antibiotics used in children with pneumonia are the most…
- Trial name
- SEARCH (NCT04041791)
- Testing
- Benzyl penicillin, Gentamicin Sulfate, Ceftriaxone
- Where
- Kenya
- Volunteers
- 4,392 people
- Sponsor
- University of Oxford
Shock, Septic, Ventricular Dysfunction, Left
Place of Echocardiography in IV Fluid Therapy in Patients With Septic Shock and Left Ventricular Systolic Dysfunction
IV fluid therapy remains an essential haemodynamic objective in the treatment strategy of septic shock. Left ventricular systolic dysfunction secondary to sepsis is observed in 40% and up to 65% of the population concerned.
- Trial name
- DYSPRED (NCT02899897)
- Testing
- echocardiography in IV fluid therapy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Intravenous Fluids, Pharmacodynamics
Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes.
- Conditions
- Intravenous Fluids, Pharmacodynamics, Fluid Therapy, Fluid Responsiveness
- Trial name
- WATERNAL (NCT05153837)
- Testing
- saline intravenous administration, oral water
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gamification
Educational Escape Room Game and Nursing Students
This study will be conducted to determine the effect of educational escape room teaching on nursing students' skills in calculating intravenous drug dosage and applying fluid therapy.
- Trial name
- NCT06451926
- Testing
- Escape room game
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Şırnak Üniversitesi
Perioperative Care
Traditional Versus ScvO2 Guided Perioperative Fluid Therapy
Perioperative goal directed fluid therapy by means of an esophageal doppler has been shown to reduce morbidity and length of stay.
- Trial name
- NCT00468793
- Testing
- Intravenous fluid
- Where
- Norway
- Volunteers
- 240 people
- Sponsor
- Haukeland University Hospital
Septic Shock
The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
The purpose of this trial is to assess patient important benefits and harms of IV fluid restriction vs. standard care fluid therapy in patients with septic shock.
- Trial name
- CLASSIC (NCT03668236)
- Testing
- Isotonic crystalloids
- Where
- 31 sites in Belgium, Czechia and 6 more
- Volunteers
- 1,554 people
- Sponsor
- Anders Perner, MD, PhD
Trauma and Emergency Care, Shock,Hemorrhagic
Delayed Fluids in Hemorrhagic Shock Due to Severe Injuries.
This study will provide information on the quality of care in hemorrhagic shock of severe injuries in a limited resource facility of Latin America, the strategies of fluid resuscitation, and outcomes.
- Conditions
- Trauma and Emergency Care, Shock,Hemorrhagic, Intravenous Fluid Therapy
- Trial name
- PERMIT-LATAM (NCT07530653)
- Testing
- Crystalloid below 1000 mL., IV fluids more than 1,000 mL
- Where
- Colombia
- Volunteers
- 716 people
- Sponsor
- Hospital Departamental de Villavicencio
Hypernatremia, Acute Watery Diarrhea
Hypernatremia Fluid Therapy in Childhood Diarrhoea
Hypernatremic dehydration is a life-threatening condition, particularly in children under two years of age, with mortality rates reaching up to as high as 19%.
- Trial name
- HOPE (NCT07884747)
- Testing
- Oral rehydration solution (ORS)
- Where
- Bangladesh
- Volunteers
- 268 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Low Birth Weight Infant, Enteral Nutrition
Oral Versus Intravenous Rehydration for Prevention of Dehydration in Premature Babies, During the First Days of Life.
This prospective randomised study comparing administration of a hypo-osmolar oral hydration solution with the classical hydration via IV (intravenous) infusion in premature infants of more than 32 weeks GA (gestational age) aims…
- Trial name
- SROPREMA (NCT00715000)
- Testing
- Oral rehydration therapy, classical hydration via intravenous infusion
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypovolemia
Plasma-Lyte 148® versUs Saline Study
The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality…
- Trial name
- PLUS (NCT02721654)
- Testing
- Plasma-Lyte 148®, 0.9% sodium chloride
- Where
- 51 sites in Australia, New Zealand
- Volunteers
- 5,037 people
- Sponsor
- The George Institute
Critical Illness, Sepsis
Role of Active Deresuscitation After Resuscitation-2
RADAR-2 will be a randomised, open-label, allocation concealed, pilot trial of conservative fluid administration and deresuscitation compared with usual care in patients who are critically ill.
- Conditions
- Critical Illness, Sepsis, Trauma
- Trial name
- RADAR-2 (NCT03512392)
- Testing
- Conservative fluid and deresuscitation strategy, Usual care strategy
- Where
- 8 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- Belfast Health and Social Care Trust
Sepsis, Fluid Overload
Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis
Sepsis is a common and life-threatening condition caused by a dysregulated host immune response to infection. Given the prominent role of endothelial breakdown and dysfunction in sepsis, therefore, there is an urgent need to…
- Conditions
- Sepsis, Fluid Overload, Endothelial Dysfunction, Microcirculation
- Trial name
- INITIALISE (NCT06626984)
- Testing
- Imatinib, Compound sodium lactate solution
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Migraine Disorders, Headache
The Effect of Intravenous Fluid Therapy in Acute Migraine Attacks
The study is a single-center, double-blind, randomized protocol comparison. The study will be conducted in Marmara University School of Medicine Pendik Training and Research Hospital, Department of Emergency Medicine between…
- Conditions
- Migraine Disorders, Headache, Acute Pain
- Trial name
- NCT04287140
- Testing
- Bolus fluid administration
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Marmara University
Fluid Management
Oral Versus Intravenous Fluid Therapy in the Emergency Department
The goal of this randomized clinical feasibility trial is to determine whether oral fluid therapy can achieve prescribed fluid volumes as effectively as intravenous fluid therapy in adult patients admitted to the emergency…
- Trial name
- OVID-B (NCT07361952)
- Testing
- Oral fluids, Intravenous fluids
- Where
- 3 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark