Clinical trials: Intravenous Therapy
Staphylococcal Skin Infection
Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus
Study 0018 (NCT00107978) compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections.
- Trial name
- ATLAS2 (NCT00107978)
- Testing
- Telavancin, Vancomycin
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- Cumberland Pharmaceuticals
Anemia
A Study of Intravenous (iv) Mircera in Hemodialysis Patients With Chronic Renal Anemia
This study will determine the appropriate dose and frequency of administration of iv Mircera maintenance therapy in hemodialysis patients with chronic renal anemia who were previously receiving iv epoetin.
- Trial name
- NCT00048035
- Testing
- methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 14 sites in United States
- Volunteers
- 91 people
- Sponsor
- Hoffmann-La Roche
Hepatitis C
A Pilot Study of High-Dose, Intravenous Ascorbic Acid (Vitamin C) to Treat Hepatitis C
The purpose of this pilot study is to learn whether high doses of ascorbic acid (vitamin c), given intravenously to patients with chronic hepatitis due to infection with the genotype 1 version of the hepatitis C virus, are safe…
- Trial name
- NCT01250743
- Testing
- ascorbic acid (vitamin C)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Health Innovations, Frontier Research Institute
Diabetic Nephropathy, Albuminuria
Effect of Sulodexide on Albuminuria in Chinese Type 2 Diabetic Patients
Current therapies targeting albuminuria in diabetic nephropathy leave residual urinary albumin secretion, which meanwhile leave residual cardiovascular risk.
- Trial name
- Soften (NCT01316068)
- Testing
- intravenous use of sulodexide followed by oral use, use of sulodexide orally only
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Mesothelioma
Phase II Anetumab Ravtansine as 2nd Line Treatment for Malignant Pleural Mesothelioma (MPM)
The main purpose of the 15743 study is to assess efficacy and safety of anetumab ravtansine versus vinorelbine in progression free survival in patients with stage IV mesothelin overexpressing malignant pleural mesothelioma (MPM).
- Trial name
- NCT02610140
- Testing
- Anetumab ravtansine (BAY94-9343), Vinorelbine
- Where
- 75 sites in United States, Australia and 12 more
- Volunteers
- 248 people
- Sponsor
- Bayer
Treatment Resistant Depression
Pharmacogenetics Associated With IV Ketamine
The Canadian Rapid Treatment Center of Excellence (CRTCE) is a healthcare facility principally focused on providing best practices of intravenous ketamine treatment to adult patients suffering from treatment resistant depression.
- Trial name
- NCT04695405
- Testing
- Saliva Genetic Samples
- Where
- Canada
- Volunteers
- 85 people
- Sponsor
- Brain and Cognition Discovery Foundation
Stroke, Acute
Intravenous Administration of Microplasmin for Treatment of Acute Ischemic Stroke
The primary purpose of this study is to evaluate the safety and preliminary efficacy of microplasmin when administered intravenously to patients who have suffered an acute stroke within 12 hours before randomization.
- Trial name
- NCT00123305
- Testing
- Microplasmin
- Where
- 16 sites in Austria, Belgium and 1 more
- Volunteers
- 40 people
- Sponsor
- ThromboGenics
Renal Anemia
Study to Determine Optimum Intravenous Starting Dose of MIRCERA for Treatment of Pediatric Participants With Anemia and Chronic Kidney Disease on Hemodialysis
This sequential study will assess the efficacy and safety of multiple doses of intravenous (IV) methoxy polyethylene glycol-epoetin beta (MIRCERA), and will determine the optimum starting dose for maintenance treatment of anemia…
- Trial name
- NCT00717366
- Testing
- Methoxy Polyethylene Glycol-Epoetin Beta
- Where
- 39 sites in Australia, Belgium and 10 more
- Volunteers
- 64 people
- Sponsor
- Hoffmann-La Roche
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Gastroenteritis, Bronchiolitis
Isotonic Versus Hypotonic Fluid for Maintenance IV Therapy
Hyponatremia associated with administration of hypotonic intravenous (IV) fluids may have serious complications. It has recently been suggested that isotonic saline may be a more appropriate choice of maintenance IV fluid.
- Conditions
- Gastroenteritis, Bronchiolitis, Sepsis, Urinary Tract Infection
- Trial name
- NCT00457873
- Testing
- 0.9% saline in 5% dextrose (intravenous), 0.45% saline in 5% dextrose (intravenous)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Newborn Complication, Hyponatremia of Newborn
Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care.
- Conditions
- Newborn Complication, Hyponatremia of Newborn, Hypernatremia of Newborn, Fluid Therapy
- Trial name
- NEOFLUID (NCT04781361)
- Testing
- Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose, Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Dokuz Eylul University
HIV Infections
PRO 140 by IV Administration in Adults With HIV-1 Infection
The purpose of this study is: 1. To assess and characterize the PK and PD of PRO 140 administered IV 2. To assess the antiviral activity of PRO 140 3. To assess the safety and tolerability of PRO 140
- Trial name
- NCT00613379
- Testing
- PRO 140
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- CytoDyn, Inc.
Guillain-Barre Syndrome
Comparison of the Efficacy and Safety of Immunoadsorption and Intravenous Immunoglobulin for Guillain-Barre Syndrome
Guillain-Barre syndrome is an immune-mediated acute inflammatory peripheral neuropathy. The currently effective treatment methods include intravenous immunoglobulin and plasma exchange.
- Trial name
- GBS-PRAISING (NCT05114941)
- Testing
- immunosorbent column, intravenous immunoglobulin
- Where
- China
- Volunteers
- 204 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Hunter Syndrome
An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment
This extension study of HGT-HIT-045 is designed to collect long-term safety data in pediatric participants with Hunter syndrome and cognitive impairment who are receiving intrathecal (IT) idursulfase-IT and intravenous (IV)…
- Trial name
- NCT01506141
- Testing
- Idursulfase-IT, Elaprase
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 15 people
- Sponsor
- Takeda
Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy
IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies
This study will enroll patients with small fiber neuropathy (SFN). The study will look at an intravenous immunoglobulin (IVIG) called Panzyga.
- Conditions
- Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy, Inflammatory Polyneuropathy, Immune-Mediated Neuropathy
- Trial name
- NCT04153422
- Testing
- Panzyga IVIG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Postoperative Vomiting
Effect of Intravenous Fluid Therapy on Postoperative Vomiting in Children Undergoing Otorhinolaryngological Surgery
The purpose of this randomized clinical trial is to evaluate the interaction of intravenous fluid therapy during otorhinolaryngological surgery, on postoperative vomiting.
- Trial name
- NCT01575600
- Testing
- Intraoperative lactated Ringer's solution
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Ignacio Cortínez F.
Pain
Oral vs IV Acetaminophen for Long-bone Fracture in Children
Intravenous (IV) acetaminophen entered the Canadian market recently and children with acute pain following a trauma are ideal candidates for the IV formulation as it may improve analgesia and consequently decrease the amount of…
- Trial name
- NCT05557344
- Testing
- Acetaminophen IV, Acetaminophen
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dr. Niina Kleiber
Gram Negative Infections, Sepsis and Septic Shock
A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections
The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspected Gram-negative bacterial infection, as demonstrated by a shorter time…
- Trial name
- CAVIFOS (NCT07063095)
- Testing
- Ceftazidime± avibactam with fosfomycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Angela HUTTNER
Anti-Infectives Adverse Reaction
Appropriateness of Intravenous Antibiotics Prescriptions at Hospital Discharge
A quasi-experimental study was conducted among patients receiving care at the medicine units of the Maharaj Nakorn Chiang Mai Hospital to determine the appropriateness of intravenous antibiotics at hospital discharge with and…
- Trial name
- NCT03173768
- Testing
- ID specialist approval
- Where
- Thailand
- Volunteers
- 173 people
- Sponsor
- Chiang Mai University
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