Clinical trials: Intrinsic Sphincter Deficiency
Female Urinary Stress Incontinence
TVT Versus TOT in Urinary Stress Incontinence With No Intrinsic Sphincter Deficiency
The aim of this study is to compare trans-vaginal tape(TVT) and trans-obturator tape(TOT) procedure in female urinary stress incontinence with no intrinsic sphincter deficiency.
- Trial name
- NCT01903590
- Testing
- TVT surgery TOT surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Urinary Incontinence, Urinary Incontinence (UI)
Trial of NASHA Dx Urethral Bulking System
Prospective, randomized, single-blind study to evaluate the safety and efficacy of NASHA Dx investigational device compared to controlled device Bulkamid in adult women with mild, moderate and intrinsic sphincter deficiency (ISD).
- Conditions
- Urinary Incontinence, Urinary Incontinence (UI), Urinary Incontinence , Stress, Urinary Incontinence Due to Urethral Sphincter Incompetence
- Trial name
- NASHA-DX (NCT07850804)
- Testing
- NASHA Dx, Bulkamid
- Where
- 5 sites in United States
- Volunteers
- 314 people
- Sponsor
- Palette Life Sciences, Inc.
Urinary Incontinence, Intrinsic Sphincter Deficiency
Injectable Bulking Agent Needle Guide
The purpose of this study is to evaluate the use of the Needle Guide as an assist in properly guiding an injection needle into the appropriate tissue plane during an injectable bulking agent procedure in women using a FDA…
- Trial name
- NG (NCT00763711)
- Testing
- Needle Guided Periurethral Injection
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Carbon Medical Technologies
Urinary Incontinence
ACT™ Balloons Versus Artificial Urinary Sphincter (AMS800™) for the Treatment of Female Stress Urinary Incontinence
The main objective is to compare the efficacy of AMS800 ™ and ACT ™ devices for the Treatment of Female Stress Urinary Incontinence due to Intrinsic Sphincter Deficiency on "social continence" at 6 months.
- Trial name
- SU-ACT (NCT02490917)
- Testing
- ACT™ device, AMS 800 ™ device
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Urinary Incontinence, Stress, Intrinsic Sphincter Deficiency
AMS AdVance and AdVance XP Male Sling Systems for the Treatment of Stress Urinary Incontinence Following Prostatectomy: Evaluation of Safety, Efficacy, and Quality of Life Through Retrospective Chart Review and Prospective Follow-up
A single-center retrospective chart review of AdVance and AdVance XP subject data, combined with prospective follow-up of the same subjects to confirm continence, adverse event, and quality of life status.
- Trial name
- NCT01725984
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- American Medical Systems
Stress Urinary Incontinence, Intrinsic Sphincter Deficiency
Local Anesthesia Before Bulkamid Injection
While recommended pre-anesthesia for polyacylamide hydrogel (PAHG, Bulkamid) injections for stress urinary incontinence and intrinsic sphincter deficiency can include intraurethral anesthetic gel with or without periurethral…
- Trial name
- LAB (NCT06043063)
- Testing
- Topical lidocaine, EMLA cream, Periurethral block
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Medstar Health Research Institute
Stress Urinary Incontinence, Urethral Intrinsic Sphincter Deficiency
A New Therapeutic Strategy for Urethral Sphincter Insufficiency
Stress urinary incontinence is a frequent condition that can be caused by urethral sphincter insufficiency and results in a dramatic deterioration of the quality of life.
- Trial name
- NCT00472069
- Testing
- transplantation of the squeletic muscular cells
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stress Urinary Incontinence, Urethral Hypermobility
Efficacy of Biofeedback-Assisted Pelvic Muscle Floor Training and Electrical Stimulation on Women With Stress Urinary Incontinence
The pathophysiological mechanism of stress urinary incontinence divides stress urinary incontinence into urethral hypermobility and intrinsic sphincter deficiency.
- Conditions
- Stress Urinary Incontinence, Urethral Hypermobility, Intrinsic Sphincter Deficiency
- Trial name
- NCT05272644
- Testing
- surface electromyographic biofeedback assisted pelvic floor muscle training, surface electromyographic biofeedback and electrical stimulation
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- Far Eastern Memorial Hospital
Stress Urinary Incontinence, Intrinsic Sphincter Deficiency
Post Market Clinical Study to Evaluate a Mid-Urethral Vaginal Tape Procedure With a Pre-Pubic Delivery Approach, for the Treatment of Stress Urinary Incontinence
The pre-pubic approach of the tension free vaginal sling placement is a new approach in the treatment of SUI. The retropubic approach of the tension free vaginal sling is the standard method of device delivery; in addition a…
- Trial name
- NCT00688298
- Testing
- Prefyx PPS™ System, Advantage ™ System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation
Female Stress Urinary Incontinence Due to Intrinsic Sphincter Deficiency
This is a Post Approval Study of Coaptite® in the Treatment of Female Urinary Incontinence
This is a post approval study of Coaptite® in the treatment of female urinary incontinence.
- Trial name
- NCT00996489
- Testing
- Coaptite®
- Where
- 20 sites in United States
- Volunteers
- 459 people
- Sponsor
- Merz North America, Inc.
Urinary Incontinence, Urinary Incontinence, Stress
Registry for Patients Undergoing AUS Surgery for Female SUI Due to ISD
Prospective collection of pre-defined parameters of AUS Surgery for Female Stress Urinary Incontinence due to Intrinsic Sphincter Deficiency
- Conditions
- Urinary Incontinence, Urinary Incontinence, Stress, Lower Urinary Tract Symptoms, Urination Disorders
- Trial name
- VENUS (NCT04114266)
- Testing
- Questionnaires on Urinary Incontinence-, Sex Function- and Quality of Life (ICIQ-UI-SF, ICIQ-FLUTSsex, ICIQ-LUTSqol, PGI-I)
- Where
- 19 sites in Belgium, Czechia and 5 more
- Volunteers
- 180 people
- Sponsor
- European Association of Urology Research Foundation
Urinary Incontinence, Stress
A Pre-Market Study of the American Medical Systems (AMS) Transobturator Male Sling System for the Treatment of Male Stress Urinary Incontinence
The purpose of this study is to obtain surgical technique data for use in physician education and training and to collect early clinical outcomes data for future publication.
- Trial name
- AMS051 (NCT00904969)
- Testing
- The AMS Male Transobturator Sling System, AdVance Male Sling
- Where
- 11 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- American Medical Systems
Urinary Incontinence by Intrinsic Sphincter Deficiency
Peri-sphincter Injection of Autologous Myofibres to Treat of Urinary Incontinence by Sphincter Deficiency
Stress urinary incontinence related to intrinsic sphincter deficiency (ISD) is a severe form of incontinence that may have a major impact on the quality of life.
- Trial name
- IPSMA (NCT02606201)
- Testing
- Peri sphincter injection Autologous myofibers
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stress Urinary Incontinence
A Post-Market Study of the AMS AdVance™ Male Sling System for the Treatment of Male Stress Urinary Incontinence
A prospective, multi-center study of the AdVance Male Sling for Stress Urinary Incontinence. The purpose of this study is to obtain surgical technique data for use in physician education and training and to collect early clinical…
- Trial name
- NCT00998790
- Testing
- American Medical Systems (AMS) AdVance™ Male Sling System
- Where
- 3 sites in Belgium, France
- Volunteers
- 114 people
- Sponsor
- Boston Scientific Corporation
Stress Urinary Incontinence
Safety and Efficacy Study of Intrasphincteric Autologous Myoblast Injection to Treat Stress Urinary Incontinence
The purpose of this pilot clinical study is to determine if intrasphincteric autologous myoblast injections in combination with electrical stimulation are safe and effective in treating stress urinary incontinence, confirming the…
- Trial name
- NCT01355133
- Testing
- Transurethral intrasphincteric autologous myoblast implantation
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Urinary Incontinence, Urinary Incontinence,Stress
Adjustable Continence Therapy (ACT) for the Treatment of Female SUI
A prospective, single arm, non-randomized, multicenter, prospective case-series trial. The purpose of this trial is to demonstrate the safety and effectiveness of using the Adjustable Continence Therapy (ACT) to provide a…
- Trial name
- NCT04248283
- Testing
- Adjustable Continence Therapy for Women (ACT)
- Where
- 8 sites in United States, France
- Volunteers
- 167 people
- Sponsor
- Uromedica
Stress Urinary Incontinence
Safety and Clinical Performance Study of the ARTUS® Artificial Urinary Sphincter (AUS)
This clinical investigation is designed as an interventional, prospective, non-randomized, open-label, single arm, multicentric and international study for obtaining CE marking.
- Trial name
- DRY (NCT04827199)
- Testing
- Artificial Urinary Sphincter implantation
- Where
- 3 sites in Czechia, Spain
- Volunteers
- 70 people
- Sponsor
- Myopowers Medical Technologies France SAS
Stress Urinary Incontinence
Peri-Urethral Platelet-Rich Plasma Injections for Postmenopausal Female Stress Urinary Incontinence
his prospective interventional study will evaluate the effectiveness and safety of peri-urethral injections of platelet-rich plasma for treating stress urinary incontinence in postmenopausal women.
- Trial name
- NCT07807982
- Testing
- Autologous Platelet-Rich Plasma
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Benha University