Clinical trials: Invasive Fungal Infections
Meningococcal Disease, Invasive
Adolescent MenACWY Booster Study
This study is to confirm non-inferiority of the three MenACWY vaccines (Menveo, Menactra or Nimenrix) in adolescents, and to identify whether the number of previous doses of MenC influences the response to the MenACWY vaccine.
- Trial name
- NCT03694405
- Testing
- MenACWY-CRM, MenACWY-DT, MenACWY-TT
- Where
- 3 sites in Canada
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Canadian Immunization Research Network
Infections, Streptococcal, Streptococcus Pneumoniae
Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A
The aim of this study is to assess the effectiveness of GSK Biologicals' pneumococcal conjugate vaccine (GSK1024850A) in preventing invasive disease caused by S. pneumoniae or H.
- Trial name
- NCT00839254
- Testing
- Pneumococcal conjugate vaccine Synflorix (GSK1024850A), GSK Biologicals' Engerix TM vaccine (Hepatitis B vaccine), GSK Biologicals' Havrix TM vaccine (Hepatitis A vaccine)
- Where
- 15 sites in Finland
- Volunteers
- 6,181 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Immunodepressed Patients (Hemato-oncology)
Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
The development of targeted therapies and intensive protocols in oncohaematology has improved the survival of patients with haematological malignancies.
- Trial name
- ADNEMIA (NCT06075888)
- Testing
- Metagenomic diagnosis (mNGS, DISQVER)
- Where
- 5 sites in France
- Volunteers
- 184 people
- Sponsor
- Poitiers University Hospital
Fungemia
Prospective Population Study on Candidemia in Spain
The aim of this study is to describe the epidemiology of fungal blood infections in Spain (with emphasis on the incidence, fungal species distribution and antifungal susceptibility).
- Trial name
- CANDIPOP (NCT01236261)
- Testing
- Non intervention
- Where
- 29 sites in Spain
- Volunteers
- 730 people
- Sponsor
- Fundacion SEIMC-GESIDA
Neutropenia, Fungal Disease
Micafungin Prevention Study for Invasive Fungal Disease in Pediatric & Adolescent Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Trial name
- NCT01417169
- Testing
- micafungin
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Aspergillosis Invasive, Fungal Infection
Individualized First Maintenance Doses of Voriconazole Through a Multiparametric Algorithm
The goal of this interventional single-arm study is to evaluate the interest of a multiparametric algorithm for individualization of first voriconazole maintenance doses for improvement of initial voriconazole exposure in adult…
- Conditions
- Aspergillosis Invasive, Fungal Infection, Hematologic Malignancy
- Trial name
- VORIPRECI (NCT06582186)
- Testing
- Individualization of first voriconazole maintenance doses
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Bloodstream Infections, Bacteremia and Sepsis
Clinical Efectiveness of a Multiplex PCR-Based Rapid Diagnostic Method in Bloodstream Infections
Bloodstream infections (BSIs) are associated with high morbidity and mortality, and delays in initiating appropriate antimicrobial therapy significantly worsen clinical outcomes.
- Conditions
- Bloodstream Infections, Bacteremia and Sepsis, Fungemia
- Trial name
- CEMP-RDI (NCT07408544)
- Testing
- Multiplex PCR-Based Rapid Diagnostic Test, Standard Microbiological Diagnostic Methods
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Medipol University Hospital
Aspergillosis/Blood, Aspergillosis/Invasive
A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis
To evaluate the therapeutic effectiveness of voriconazole + micafungin versus voriconazole alone as primary therapy for invasive aspergillosis.
- Trial name
- NCT00423163
- Testing
- micafungin, voriconazole
- Where
- 44 sites in United States
- Sponsor
- Astellas Pharma Inc
Acute Leukemia, Invasive Fungal Infection
Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia
The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.
- Trial name
- MBL INFFONG (NCT02823132)
- Testing
- blood sample
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diphtheria, Tetanus
Study of the DTaP-IPV-Hep B-PRP~T Combined Vaccine Following a Primary Series of DTacP IPV-HepB-PRP-T or Infanrix Hexa™
This is a follow-up of Study A3L11 (NCT00404651). Immunogenicity To describe the antibody persistence following a primary series vaccination of either DTaP-IPV-Hep B-PRP~T or Infanrix hexa™.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00654901
- Testing
- DTaP-IPV-Hep B-PRP~T vaccine (Batch 1), DTaP-IPV-Hep B-PRP~T vaccine (Batch 2), DTaP-IPV-Hep B-PRP~T vaccine (Batch 3)
- Where
- 4 sites in Mexico
- Volunteers
- 881 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Candidiasis, Cryptococcosis
A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections
The purpose of this study is to evaluate the efficacy and safety of Vfend for the treatment of fungal infections
- Conditions
- Candidiasis, Cryptococcosis, Aspergillosis
- Trial name
- NCT00647907
- Testing
- Voriconazole
- Where
- 4 sites in Taiwan
- Volunteers
- 7 people
- Sponsor
- Pfizer
Refractory IPA
Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis (OPERA-T Study)
To assess the safety and efficacy of nebulized PC945 in combination with systemic antifungal therapy for the treatment of refractory IPA
- Trial name
- NCT05238116
- Testing
- PC945
- Where
- 83 sites in United States, Argentina and 18 more
- Volunteers
- 85 people
- Sponsor
- Pulmocide Ltd