Clinical trials: Investigation Time
Lung Neoplasms, Pulmonary Surgical Procedures
Staple-line Reinforcement for Prevention of Pulmonary Air Leakage
The aim of this study is to compare the efficacy of FORESEAL with stapling alone or associated with tissue sealant or glue in terms of air leakage duration after lung resection for cancer.
- Conditions
- Lung Neoplasms, Pulmonary Surgical Procedures, Surgical Staplers, Tissue Adhesives
- Trial name
- SPIRAL (NCT00925444)
- Testing
- FOREseal, Stapling
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oedema, Pulmonary
A First Time in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2798745 in Healthy Subjects and Stable Heart Failure Patients
This study is the first administration of GSK2798745 in humans. This will be a sponsor un-blinded, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GSK2798745…
- Trial name
- NCT02119260
- Testing
- GSK2798745 solution, GSK2798745 suspension, GSK2798745 capsule
- Where
- 2 sites in United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Opioid Consumption, Postoperative, ESPB
Evaluation of the Postoperative Efficacy of Bilateral Lumbar Erector Spinae Plane Block (ESPB) in Patients Undergoing Lumbar Disc Herniation Repair Surgery
This prospective observational study aims to evaluate the efficacy of bilateral lumbar erector spinae plane (ESP) block in providing effective postoperative analgesia and its potential impact on early mobilization and length of…
- Conditions
- Opioid Consumption, Postoperative, ESPB, Postoperative Pain, Plane Blocks
- Trial name
- NCT07403734
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Cystic Fibrosis, Healthy
Real-Time Assessment of Lung Structure and Function in Children and Young Adults With CF Using Electrical Impedance Tomography
The purpose of this study is to determine the ability of electrical impedance tomography (EIT) to identify structural and functional physiological changes that occur with disease progression in cystic fibrosis patients.
- Trial name
- NCT05455671
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Quality Control, Validation Study
Comparison of Four Methods for Entering the Gap Position of Landolt Cs
The aim of this study is to investigate and compare the validity of four different input methods for Landolt Cs, i.e. the proportion of correct gap positions in relation to the total number of performances.
- Trial name
- LC_Entry (NCT04299659)
- Testing
- Landolt C entry method
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalen University
Duration of Analgesia, Pain Score
Evaluation of Intrathecal Hyperbaric Bupivacaine With Dexmedetomidine in Adults Undergoing Perianal Surgery
The aim of this study is to evaluate the effects of adding 5-mcg dexmedetomidine to hyperbaric bupivacaine in our population as it has never been published before, to enhance the duration of analgesia after perianal procedures…
- Trial name
- DEX-BUP (NCT07651488)
- Testing
- Dexmedetomidine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Liaquat National Hospital & Medical College
Stroke, Acute
Stroke DOC Arizona TIME - Stroke Team Remote Evaluation Using a Digital Observation Camera
Noninvasive prospective multi-center study of an interactive 2-way, wireless or site-independent, audiovisual telemedicine system designed for real-time remote examination of acute stroke symptoms and deficits as a basis for…
- Trial name
- NCT00623350
- Testing
- Telephone, Two way audio/video telemedicine consult
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Premature Birth
Assessment of Factors Influencing Parents' Attendance Time During Feeding Time of Premature Infants Born Before 35 Weeks of Amenorrhea in Besançon University Hospital
The precise description of parental presence and the associated factors will make it possible to construct an intervention in order to correct potentially low parental participation.
- Trial name
- PréPaLim (NCT05177913)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dyslipidemia, Hyperlipidemia
Rosuvastatin Adherence App Study in China
This is a randomized, two-arm, open label, Phase IV clinical trial to evaluate if the provision of a smart phone-based patient support tool prolongs the patient's rosuvastatin treatment duration.
- Trial name
- eHELP China (NCT02433288)
- Testing
- Smart phone based patient support tool, Control application: only for data collection
- Where
- 25 sites in China
- Volunteers
- 885 people
- Sponsor
- AstraZeneca
Abdominal Neoplasm, Thoracic Neoplasm
Ultrasound-assisted Thoracic Epidural Catheter Insertion
The aim of the present study is to access the success rate of ultrasound-guided thoracic epidural catheter insertion, using fluoroscopy.
- Trial name
- NCT03890640
- Testing
- Ultrasound-guided TECI
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Multiple Sclerosis
Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial
The purpose of this trial is to evaluate the effects of Rebif® 44 mcg subcutaneous (sc) three times a week (tiw) on a) remyelination/demyelination, b) lesion and brain volume, c) central nervous system (CNS) iron deposition, and…
- Trial name
- NCT01085318
- Testing
- Rebif
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- EMD Serono
Depressive Disorders, Anxiety Disorders
Study on a Digital Ultra-Brief Intervention During Wait Times for Psychotherapy
The OPTIBRIEF study investigates different versions of a digital ultra-brief intervention (UKADO - a German acronym for ultra-brief intervention against anxiety and depression online) during the waiting period for psychotherapy.
- Trial name
- OPTIBRIEF (NCT07167849)
- Testing
- UKADO Content - problem-focused, UKADO Content - resource-focused, Human support
- Where
- Switzerland
- Volunteers
- 312 people
- Sponsor
- University of Bern
Spinal Anesthesia, Machine Learning
Machine Learning for Predicting Spinal Anesthesia Duration
Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications.
- Conditions
- Spinal Anesthesia, Machine Learning, Knee Arthroplasty, Total, Spinal Anesthesia Duration
- Trial name
- NCT07256548
- Testing
- Spinal Anesthesia (bupivacaine)
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Kocaeli City Hospital
Healthy
Nurofen Ibuprofen Orodispersible Tablet Disintegration Study
Disintegration time is an important quality attribute of ODTs, and the evaluation of disintegration time is positioned as a key step in formulation development, manufacturing, and clinical practice.
- Trial name
- NCT03658720
- Testing
- 200 mg Ibuprofen acid orodispersible tablet
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Radiculopathy Lumbar
Clinical and MRI Factors Associated With Procedural Difficulty in Lumbar TFESI
The technical difficulty of transforaminal epidural steroid injection (TFESI) may be influenced by patient-related characteristics, the target spinal level, a history of lumbar surgery, the presence of spinal instrumentation, and…
- Trial name
- NCT07870720
- Volunteers
- 190 people
- Sponsor
- Selcuk University
Dry Eye Syndrome
Correlation of Different Signs for Assessment of Dry Eye Syndrome
Dry eye syndrome (DES) is a highly prevalent ocular condition inducing an inflammatory response of the ocular surface. Common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential…
- Trial name
- NCT01753687
- Testing
- Ocular scattering of the tear film, Optical Coherence Tomography (OCT), Measurement of tear film osmolarity
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Infection, Human Immunodeficiency Virus
Single Dose Escalation Study of GSK2838232 in Healthy Subjects
GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. This study is the first administration of GSK2838232 in humans to establish the initial safety…
- Trial name
- NCT01802918
- Testing
- GSK2838232, Ritonavir
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Overactive Bladder (OAB), Premature (Early) Ejaculation
Effect of Antimuscarinic Treatment on Premature Ejaculation Severity in Men With Overactive Bladder: a Prospective Comparison With Mirabegron
Overactive bladder (OAB) is a condition characterized by involuntary bladder contractions. Antimuscarinic drugs are commonly used to treat OAB by blocking muscarinic receptors (M2 and M3) in the bladder.
- Conditions
- Overactive Bladder (OAB), Premature (Early) Ejaculation, Ejaculation Abnormal
- Trial name
- NCT07736560
- Testing
- Tolterodine, Mirabegron (beta3-adrenoceptor agonist)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Japanese Encephalitis
Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children
This study has aim to describe the immune response to the second dose of Japanese encephalitis chimeric vaccine (JECV) in children previously vaccinated with one dose of JECV 5 years ago.
- Trial name
- NCT01954810
- Testing
- Japanese encephalitis chimeric vaccine (JECV)
- Where
- Thailand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Herpes Zoster
A Study on the Immune Response and Safety of the Shingles Vaccine and the Influenza Vaccine When Either is Given to Healthy Adults at the Same Time or Following a COVID-19 Booster Vaccine
The aim of this study was to evaluate the immune response and safety of both GlaxoSmithKline Biologicals SA's (GSK's) herpes zoster (HZ) subunit (su) vaccine in healthy adults 50 years of age (YOA) and older and quadrivalent…
- Trial name
- NCT05047770
- Testing
- HZ/su, Flu D-QIV, mRNA-1273
- Where
- 46 sites in United States
- Volunteers
- 2,013 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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